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Low-Cost, Volume-Controlled Dipstick Urinalysis for Home-Testing

Dipstick urinalysis provides quick and affordable estimations of multiple physiological conditions but requires good technique and training to use ...

Vanderbilt University

The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data, including current approaches used in modeling light scattering in tissue and in AC estimation. We also report on demonstrated clinical applications of the AC, such as for atherosclerotic tissue characterization, malignant lesion detection, and brain injury visualization. With current studies showing AC analysis as a promising technique, further efforts in the development of methods to accurately extract the AC and to explore its potential use for more extensive clinical applications are desired.

Review of methods and applications of attenuation coefficient measurements with optical coherence tomography.

This feature issue of  presents a cross-section of interesting and emerging work of relevance to optical technologies in low-resource settings. In particular, the technologies described here aim to address challenges to meeting healthcare needs in resource-constrained environments, including in rural and underserved areas. This collection of 18 papers includes papers on both optical system design and image analysis, with applications demonstrated for ex vivo and in vivo use. All together, these works portray the importance of global health research to the scientific community and the role that optics can play in addressing some of the world's most pressing healthcare challenges.

Article	Year
Review of methods and applications of attenuation coefficient measurements with optical coherence tomography. Journal of biomedical optics\| PubMed ID: 31520468	2019
Optical Technologies for Improving Healthcare in Low-Resource Settings: introduction to the feature issue. Biomedical optics express\| PubMed ID: 32637243	2020

Audrey K. Bowden

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