Simon Melov

Buck Institute for Research on Aging

Affiliated withBuck Institute for Research on Aging

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2011

Other Publications

Article	Year
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease. Trends in neurosciences\| PubMed ID: 11852134	2002
Applied proteomics: mitochondrial proteins and effect on function. Circulation research\| PubMed ID: 11884366	2002
Therapeutics against mitochondrial oxidative stress in animal models of aging. Annals of the New York Academy of Sciences\| PubMed ID: 11976207	2002
Animal models of oxidative stress, aging, and therapeutic antioxidant interventions. The international journal of biochemistry & cell biology\| PubMed ID: 12200034	2002
Microarray workshop on aging. Mechanisms of ageing and development\| PubMed ID: 12618016	2003
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature cell biology\| PubMed ID: 12855956	2003
Oxidative stress and aging: beyond correlation. Aging cell\| PubMed ID: 12882341	2002
Spotlight on nematode mitochondria in RNAi mega-screen. Science of aging knowledge environment : SAGE KE\| PubMed ID: 14603016	2002
Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. Journal of neurochemistry\| PubMed ID: 14720215	2004
Microarray analysis of gene expression with age in individual nematodes. Aging cell\| PubMed ID: 15153179	2004
Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples. Electrophoresis\| PubMed ID: 15300776	2004
Modeling mitochondrial function in aging neurons. Trends in neurosciences\| PubMed ID: 15374671	2004
Proteomic analysis of mitochondrial proteins. International review of neurobiology\| PubMed ID: 15482810	2004
Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future. Science of aging knowledge environment : SAGE KE\| PubMed ID: 15498758	2004
Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free radical biology & medicine\| PubMed ID: 15607908	2005
Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free radical biology & medicine\| PubMed ID: 15964507	2005
Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase. Breast (Edinburgh, Scotland)\| PubMed ID: 16085231	2005
Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR. Mitochondrion\| PubMed ID: 16120406	2004
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. The Journal of clinical investigation\| PubMed ID: 16127459	2005
Biomarker discovery and analysis platform: application to Alzheimer's disease. BioTechniques\| PubMed ID: 16235574	2005
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO reports\| PubMed ID: 16264422	2005
Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. The Journal of biological chemistry\| PubMed ID: 16326710	2006
Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS genetics\| PubMed ID: 16450009	2006
Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17093086	2006
Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging cell\| PubMed ID: 17286610	2007
Resistance exercise reverses aging in human skeletal muscle. PloS one\| PubMed ID: 17520024	2007
Mitochondrial oxidative stress causes hyperphosphorylation of tau. PloS one\| PubMed ID: 17579710	2007
Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiological genomics\| PubMed ID: 17957000	2008
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. The Journal of biological chemistry\| PubMed ID: 17959600	2008
Gene expression changes associated with aging in C. elegans. WormBook : the online review of C. elegans biology\| PubMed ID: 18050504	2007
Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging cell\| PubMed ID: 18778409	2008
Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free radical biology & medicine\| PubMed ID: 19038329	2009
A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS genetics\| PubMed ID: 19293945	2009
Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women. PloS one\| PubMed ID: 19654872	2009
Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PloS one\| PubMed ID: 20502695	2010
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell metabolism\| PubMed ID: 20816092	2010
Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free radical biology & medicine\| PubMed ID: 21215798	2011
The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Experimental gerontology\| PubMed ID: 21296648	2011
Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21368114	2011
Loss of intestinal nuclei and intestinal integrity in aging C.Â elegans. Aging cell\| PubMed ID: 21501374	2011
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell metabolism\| PubMed ID: 21723504	2011
Cellular senescence: a link between cancer and age-related degenerative disease? Seminars in cancer biology\| PubMed ID: 21925603	2011
On the programmed/non-programmed nature of ageing within the life history. Current biology : CB\| PubMed ID: 21959160	2011
Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PloS one\| PubMed ID: 22174832	2011
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging\| PubMed ID: 22278880	2012
Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage. Science translational medicine\| PubMed ID: 22301554	2012