Lars Hviid

Centre for Medical Parasitology, University of Copenhagen

Affiliated withUniversity of Copenhagen Rigshospitalet

Research Area

Biography

Lars Hviid is a Professor at the Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Denmark. He holds PhD and DMSc degrees from University of Copenhagen.

Prof. Hviid has studied targets and mechanisms of human acquired protective immunity to Plasmodium falciparum malaria for more than 30 years, mostly in collaboration with colleagues at universities in Africa. He is particularly interested in the role of the clonally variant parasite protein family PfEMP1, which is a key virulence factor and an important target of antibody-mediated immunity against the parasite-infected erythrocytes. Prof. Hviid was one of the first to use flow cytometry in this kind of research. He has published close to 200 peer-reviewed research papers.

Prof. Hviid is an elected Fellow (2013) of the American Society for Tropical Medicine and Hygiene (ASTMH) and an elected Fellow (2020) of the African Academy of Sciences (AAS).

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2020

Other Publications

Article	Year
Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum mala... Infection and immunity\| PubMed ID: 15321995	2004
Looking for Needles in the Plasmodial Haystack. mSphere\| PubMed ID: 30918061	2019
Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. Infection and immunity\| PubMed ID: 10225865	1999
A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. Infection and immunity\| PubMed ID: 10338508	1999
Nine-year longitudinal study of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes. Infection and immunity\| PubMed ID: 10417178	1999
Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. Infection and immunity\| PubMed ID: 11160024	2001
What is the cause of lymphopenia in malaria? Infection and immunity\| PubMed ID: 11203040	2000
Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria. Infection and immunity\| PubMed ID: 11292740	2001
Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children. Infection and immunity\| PubMed ID: 11349035	2001
Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity. Infection and immunity\| PubMed ID: 11500389	2001
Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens. Clinical and diagnostic laboratory immunology\| PubMed ID: 11687480	2001
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11907103	2002
Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria. Clinical and diagnostic laboratory immunology\| PubMed ID: 11986285	2002
Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens. Infection and immunity\| PubMed ID: 12010988	2002
A sub-family of common and highly conserved Plasmodium falciparum var genes. Molecular and biochemical parasitology\| PubMed ID: 12076777	2002
In vivo switching between variant surface antigens in human Plasmodium falciparum infection. The Journal of infectious diseases\| PubMed ID: 12195363	2002
Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria. Immunology letters\| PubMed ID: 12270550	2002
Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. Infection and immunity\| PubMed ID: 12595482	2003
Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responses. Infection and immunity\| PubMed ID: 12654861	2003
Acute P. falciparum malaria induces a loss of CD28- T IFN-gamma producing cells. Parasite immunology\| PubMed ID: 12694605	2002
Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria. Infection and immunity\| PubMed ID: 12819117	2003
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Molecular microbiology\| PubMed ID: 12823820	2003
Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet (London, England)\| PubMed ID: 14751701	2004
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. The Journal of experimental medicine\| PubMed ID: 15123742	2004
Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens. Infection and immunity\| PubMed ID: 15155661	2004
Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates. Malaria journal\| PubMed ID: 15242514	2004
Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria. Infection and immunity\| PubMed ID: 15501780	2004
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. The Journal of experimental medicine\| PubMed ID: 15520249	2004
Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae. Infection and immunity\| PubMed ID: 15845489	2005
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans. Malaria journal\| PubMed ID: 15857512	2005
Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigens. Infection and immunity\| PubMed ID: 15972500	2005
Differential induction of immunoglobulin G to Plasmodium falciparum variant surface antigens during the transmission season in Daraweesh, Sudan. The Journal of infectious diseases\| PubMed ID: 15995968	2005
Naturally acquired immunity to Plasmodium falciparum malaria in Africa. Acta tropica\| PubMed ID: 16018958	2005
Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protec... Infection and immunity\| PubMed ID: 16622225	2006
Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo. Infection and immunity\| PubMed ID: 16622246	2006
Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes. Infection and immunity\| PubMed ID: 16790811	2006
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration. PLoS pathogens\| PubMed ID: 17112315	2006
Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Molecular microbiology\| PubMed ID: 17176260	2007
Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria. Infection and immunity\| PubMed ID: 17283085	2007
Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity. Microbes and infection\| PubMed ID: 17398137	2007
Selective activation of TCR-gammadelta+ cells in endemic Burkitt's lymphoma. Malaria journal\| PubMed ID: 17521425	2007
Adhesion specificities of Plasmodium falciparum-infected erythrocytes involved in the pathogenesis of pregnancy-associated malaria. The American journal of pathology\| PubMed ID: 17525250	2007
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites. Malaria journal\| PubMed ID: 17565661	2007
Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania. Infection and immunity\| PubMed ID: 18250179	2008
Malaria vaccines: immunity, models and monoclonal antibodies. Trends in parasitology\| PubMed ID: 18675589	2008
VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. The Journal of infectious diseases\| PubMed ID: 18700835	2008
CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression. Malaria journal\| PubMed ID: 18844973	2008
Variant-specific immunity to Plasmodium berghei in pregnant mice. Infection and immunity\| PubMed ID: 19237516	2009
Unraveling the impact of malaria exposure before birth. PLoS medicine\| PubMed ID: 19636354	2009
The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development. Human vaccines\| PubMed ID: 19823032	2010
Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical model. PloS one\| PubMed ID: 20339540	2010
The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs. Malaria journal\| PubMed ID: 20403153	2010
Of mice and women: rodent models of placental malaria. Trends in parasitology\| PubMed ID: 20605743	2010
Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children. Infection and immunity\| PubMed ID: 20823214	2010
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21078904	2010
Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746929	2011
The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria. Expert review of vaccines\| PubMed ID: 21988306	2011
Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733729	2012
Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia. Malaria journal\| PubMed ID: 22853732	2012
The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates. PloS one\| PubMed ID: 23029166	2012
A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23209327	2013
Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1. PloS one\| PubMed ID: 23874884	2013
Transfected HEK293 cells expressing functional recombinant intercellular adhesion molecule 1 (ICAM-1)--a receptor associated with severe Plasmodium falciparum malaria. PloS one\| PubMed ID: 23936131	2013
Cytokine response to pregnancy-associated recrudescence of Plasmodium berghei infection in mice with pre-existing immunity to malaria. Malaria journal\| PubMed ID: 24180253	2013
Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa. PloS one\| PubMed ID: 24520349	2014
B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites. Infection and immunity\| PubMed ID: 24566620	2014
Kinetics of B cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24760153	2014
Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites. PLoS biology\| PubMed ID: 24983235	2014
Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting. Cellular microbiology\| PubMed ID: 25482886	2015
Trying to remember: immunological B cell memory to malaria. Trends in parasitology\| PubMed ID: 25596801	2015
PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis. Advances in parasitology\| PubMed ID: 25911365	2015
Rifins, rosetting, and red blood cells. Trends in parasitology\| PubMed ID: 25959958	2015
α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes. PLoS pathogens\| PubMed ID: 26134405	2015
Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ. Infection and immunity\| PubMed ID: 26216422	2015
Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed. mBio\| PubMed ID: 26443460	2015
Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria. Trends in parasitology\| PubMed ID: 26597020	2016
[A worm in the toilet]. Ugeskrift for laeger\| PubMed ID: 27063009	2016
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell host & microbe\| PubMed ID: 28279348	2017
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation. Malaria journal\| PubMed ID: 29338760	2018
Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria. Infection and immunity\| PubMed ID: 29426042	2018
Etiology of Placental Plasmodium falciparum Malaria in African Women. The Journal of infectious diseases\| PubMed ID: 29579263	2018
IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax. Infection and immunity\| PubMed ID: 29784859	2018
Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria. PloS one\| PubMed ID: 29883485	2018
A vaccine targeted specifically to prevent cerebral malaria - is there hope? Expert review of vaccines\| PubMed ID: 29898617	2018
Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes. PloS one\| PubMed ID: 30300360	2018
Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools. Malaria journal\| PubMed ID: 30537973	2018
Evasion of Classical Complement Pathway Activation on -Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Frontiers in immunology\| PubMed ID: 30666256	2018
Human Vδ1 T Cells in the Immune Response to Infection. Frontiers in immunology\| PubMed ID: 30837999	2019
Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region. Infection and immunity\| PubMed ID: 30988054	2019
Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones. Scientific reports\| PubMed ID: 30988351	2019
Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C. Infection and immunity\| PubMed ID: 31308082	2019
Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it. Immunological reviews\| PubMed ID: 31562653	2020
Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana. BMC cancer\| PubMed ID: 31888714	2019
Endemic Burkitt lymphoma - an aggressive childhood cancer linked to Plasmodium falciparum exposure, but not to exposure to other malaria parasites. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 32133709	2020
Precipitated Malaria: It Never Rains but It Pours. Trends in parasitology\| PubMed ID: 32507384	2020
In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression. Scientific reports\| PubMed ID: 32732983	2020