isolation-mouse-kidney-resident-cd8-t-cells-for-flow-cytometry

Isolation of Mouse Kidney-Resident CD8<sup>+</sup> T cells for Flow Cytometry Analysis

Tissue-resident memory T cell (TRM) is a rapidly expanding field of immunology research. Isolating T cells from various non-lymphoid tissues is one of the ...

University of Texas Health Science Center at San Antonio

The long-term maintenance of memory T cells is essential for successful vaccines. Both the quantity and the quality of the memory T-cell population must be maintained. The signals that control the maintenance of memory T cells remain incompletely identified. Here we used two genetic models to show that continuous transforming growth factor-β signaling to antigen-specific T cells is required for the differentiation and maintenance of memory CD8(+) T cells. In addition, both infection-induced and microbiota-induced inflammation impact the phenotypic and functional identity of memory CD8(+) T cells. 

Transforming growth factor-β signaling is constantly shaping memory T-cell population.

Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of TRMs. Here, we discuss recent advances in the TRM field with a special emphasis on the interaction between local signals and TRMs in the context of individual tissue environment.

Article	Year
Transforming growth factor-β signaling is constantly shaping memory T-cell population. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26283373	2015
Tissue-Specific Control of Tissue-Resident Memory T Cells. Critical reviews in immunology\| PubMed ID: 29953389	2018

Chaoyu Ma

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