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Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy

Based on twice transverse aortic constrictions (TACs) in mice, it is proved that myocardial hypertrophic preconditioning (MHP) could attenuate ...

Southern Medical University

To investigate the effects of ultrasound mediated microbubble destruction on capillary permeability in rat skeletal muscles.

[Ultrasound-mediated microbubble destruction increases capillary permeability in rat skeletal muscles].

To test the feasibility and accuracy of myocardial contrast echocardiography (MCE) for predicting infarct size (IS) in a rat model of myocardial infarction (MI) and to compare a simplified single plane-based measurement of IS with the conventional three plane-based approach. Fifty male SD rats underwent left anterior descending artery ligation and were evaluated by MCE 8 h post MI. IS was calculated by the single and three plane-based approaches, compared to that determined by triphenyltetrazolium chloride (TTC) staining method. Simplified single plane-based MCE approach and TTC method showed similar IS values (38.48 +/- 16.80% vs. 35.72 +/- 15.33%, P > 0.05) and presented a favorable positive correlation (r = 0.851, P < 0.001). IS values derived from simplified single plane-based approach was also highly significantly correlated with that by the conventional MCE method (r = 0.973, P < 0.001). Bland-Altman plots also displayed satisfactory agreement between them. MCE was validated as a novel technique to quantify infarct area in rats with MI. A single measurement at the mid-papillary muscle level may become a simple, efficient and reliable approach for in vivo IS assessment.

Evaluation and simplified measurement of infarct size by myocardial contrast echocardiography in a rat model of myocardial infarction.

The best time to perform percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients presenting 12 to 72 hours after chest pain is unclear. The aim of this study was to explore whether delayed PCI was superior to emergency PCI in STEMI patients who presented 12 to 72 hours after onset of symptoms and with a spontaneous reperfusion infarct-related artery (IRA).

Delayed angioplasty is superior to an emergency strategy in ST-segment elevation myocardial infarction patients who present late and with infarct artery spontaneous reperfusion before intervention.

Article	Year
[Ultrasound-mediated microbubble destruction increases capillary permeability in rat skeletal muscles]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 18495585	2008
Evaluation and simplified measurement of infarct size by myocardial contrast echocardiography in a rat model of myocardial infarction. The international journal of cardiovascular imaging\| PubMed ID: 19626456	2009
Delayed angioplasty is superior to an emergency strategy in ST-segment elevation myocardial infarction patients who present late and with infarct artery spontaneous reperfusion before interv... Cardiovascular journal of Africa\| PubMed ID: 31144708	2019

Yi Lao

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