Robert B. Clarke

Breast Biology Group, University of Manchester

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2020

Other Publications

Article	Year
A putative human breast stem cell population is enriched for steroid receptor-positive cells. Developmental biology\| PubMed ID: 15617686	2005
Do early premalignant changes in normal breast epithelial cells predict cancer development? Breast cancer research : BCR\| PubMed ID: 15642177	2005
Stem cells and tissue homeostasis in mammary glands. Journal of mammary gland biology and neoplasia\| PubMed ID: 15886881	2005
Human breast epithelial stem cells and their regulation. The Journal of pathology\| PubMed ID: 16294373	2006
Isolation and characterization of human mammary stem cells. Cell proliferation\| PubMed ID: 16300651	2005
Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions. Nature clinical practice. Oncology\| PubMed ID: 16341119	2005
Ovarian steroids and the human breast: regulation of stem cells and cell proliferation. Maturitas\| PubMed ID: 16806749	2006
High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? Breast cancer research : BCR\| PubMed ID: 17076877	2006
Estrogen deprivation for breast cancer prevention. Recent results in cancer research. Fortschritte der Krebsforschung. ProgrÃ¨s dans les recherches sur le cancer\| PubMed ID: 17302193	2007
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. Journal of the National Cancer Institute\| PubMed ID: 17440163	2007
Origins of breast cancer subtypes and therapeutic implications. Nature clinical practice. Oncology\| PubMed ID: 17728710	2007
Mammary stem cells and breast cancer--role of Notch signalling. Stem cell reviews\| PubMed ID: 17873349	2007
The origin of estrogen receptor alpha-positive and alpha-negative breast cancer. Advances in experimental medicine and biology\| PubMed ID: 18497032	2008
Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity. Breast cancer research : BCR\| PubMed ID: 18681966	2008
The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis. BMC medical genomics\| PubMed ID: 18803878	2008
Are stem-like cells responsible for resistance to therapy in breast cancer? Breast disease\| PubMed ID: 19029627	2008
Resistance to endocrine therapy: are breast cancer stem cells the culprits? Journal of mammary gland biology and neoplasia\| PubMed ID: 19252972	2009
Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19258541	2009
Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer. Breast cancer research : BCR\| PubMed ID: 19563669	2009
Biomarkers of dietary energy restriction in women at increased risk of breast cancer. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19656771	2009
It's all in the details: methods in breast development and cancer. Breast cancer research : BCR\| PubMed ID: 19691817	2009
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer research\| PubMed ID: 20068161	2010
Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biology direct\| PubMed ID: 20406437	2010
The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Molecular and cellular biology\| PubMed ID: 20606007	2010
Breast cancer stem cells: something out of notching? Cancer research\| PubMed ID: 21045140	2010
Breast cancer stem cells and their role in resistance to endocrine therapy. Hormones & cancer\| PubMed ID: 21761332	2011
Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model. PloS one\| PubMed ID: 21915302	2011
The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts. Breast cancer research : BCR\| PubMed ID: 22017807	2011
Stem cells in breast tumours: are they ready for the clinic? European journal of cancer (Oxford, England : 1990)\| PubMed ID: 22542086	2012
A detailed mammosphere assay protocol for the quantification of breast stem cell activity. Journal of mammary gland biology and neoplasia\| PubMed ID: 22665270	2012
Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23149820	2013
Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status. Cancer research\| PubMed ID: 23248117	2013
Combining Notch inhibition with current therapies for breast cancer treatment. Therapeutic advances in medical oncology\| PubMed ID: 23323144	2013
Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status. PloS one\| PubMed ID: 23457626	2013
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast cancer research : BCR\| PubMed ID: 23497505	2013
Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23839043	2013
Wnt pathway activity in breast cancer sub-types and stem-like cells. PloS one\| PubMed ID: 23861811	2013
Targeting IL-8 signalling to inhibit breast cancer stem cell activity. Expert opinion on therapeutic targets\| PubMed ID: 24032691	2013
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells. Breast cancer research : BCR\| PubMed ID: 24041156	2013
‘The charmingest place’: non-coding RNA, lineage tracing, tumor heterogeneity, metastasis and metabolism--new methods in mammary gland development and cancer: the fifth ENBDC Workshop. Breast cancer research : BCR\| PubMed ID: 24103450	2013
Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS). Cell cycle (Georgetown, Tex.)\| PubMed ID: 24247151	2014
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast cancer research : BCR\| PubMed ID: 24286369	2013
Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity. Oncotarget\| PubMed ID: 24334332	2013
P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells. Oncotarget\| PubMed ID: 24553076	2014
A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget\| PubMed ID: 24583601	2014
17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Oncotarget\| PubMed ID: 24931391	2014
Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer discovery\| PubMed ID: 25185190	2014
Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem cells (Dayton, Ohio)\| PubMed ID: 25187396	2015
Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer. Oncotarget\| PubMed ID: 25277201	2014
Risk determination and prevention of breast cancer. Breast cancer research : BCR\| PubMed ID: 25467785	2014
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. Oncotarget\| PubMed ID: 26087309	2015
Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells. Oncotarget\| PubMed ID: 26323205	2015
The seventh ENBDC workshop on methods in mammary gland development and cancer. Breast cancer research : BCR\| PubMed ID: 26330220	2015
The role of steroid hormones in breast cancer stem cells. Endocrine-related cancer\| PubMed ID: 26381288	2015
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity. Cell reports\| PubMed ID: 26387946	2015
An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation. Oncotarget\| PubMed ID: 26595803	2016
A Role for Notch Signalling in Breast Cancer and Endocrine Resistance. Stem cells international\| PubMed ID: 26880941	2016
Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling. Oncotarget\| PubMed ID: 27102300	2016
Intermittent energy restriction induces changes in breast gene expression and systemic metabolism. Breast cancer research : BCR\| PubMed ID: 27233359	2016
SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27621461	2016
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis. Journal of mammary gland biology and neoplasia\| PubMed ID: 27680982	2016
Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis. Journal of mammary gland biology and neoplasia\| PubMed ID: 27815673	2016
Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop "Methods in Mammary Gland Development and Cancer". Breast cancer research : BCR\| PubMed ID: 27887657	2016
Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer metastasis reviews\| PubMed ID: 28025748	2016
Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature reviews. Cancer\| PubMed ID: 28104906	2017
GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment. Breast cancer research : BCR\| PubMed ID: 29212519	2017
G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts. International journal of molecular sciences\| PubMed ID: 29240722	2017
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29363524	2018
Ethnicity influences breast cancer stem cells' drug resistance. The breast journal\| PubMed ID: 29498455	2018
The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells. Current stem cell reports\| PubMed ID: 29600163	2018
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors. Therapeutic advances in medical oncology\| PubMed ID: 29636827	2018
Hormones and cancer: update from Tokyo 2010. Expert review of endocrinology & metabolism\| PubMed ID: 30764033	2011
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4. BMC cancer\| PubMed ID: 30975104	2019
Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors. Cancers\| PubMed ID: 31083574	2019
PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer. Cancer letters\| PubMed ID: 31121213	2019
The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. Journal of mammary gland biology and neoplasia\| PubMed ID: 31529195	2019
The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling. Molecular cancer research : MCR\| PubMed ID: 31570655	2019
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nature communications\| PubMed ID: 31676788	2019
Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts. Breast cancer research : BCR\| PubMed ID: 31783893	2019
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer. Oncogene\| PubMed ID: 32472077	2020
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. Cancers\| PubMed ID: 32485849	2020
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH Breast Cancer Stem Cells. Stem cell reports\| PubMed ID: 32707076	2020