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Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards

Electroretinogram (ERG) is the only clinical objective test available to assess retinal function. Full-field ERG (ffERG) measures the panretinal rod and ...

University of Miami

University of Miami Miller School of Medicine

To directly compare cancer incidence among Hispanic children and non-Hispanic white children in California and Florida, two states in the United States of America that include nearly one in three Hispanic children in the country.

Cancer incidence among Hispanic children in the United States.

Cigarette smoking can lead to systemic endothelial dysfunction. Since the airway circulation is exposed to a high concentration of cigarette smoke constituents, we reasoned that airway vascular endothelial dysfunction could be present in healthy smokers without systemic endothelial dysfunction.

Airway vascular endothelial function in healthy smokers without systemic endothelial dysfunction.

To develop a safe, noninvasive, noncontact, continuous in vivo method to measure the dehydration rate of the precorneal tear film and to compare the effectiveness of a viscoelastic agent in maintaining the precorneal tear film to that of a balanced salt solution.

A new, specular reflection-based, precorneal tear film stability measurement technique in a rabbit model: viscoelastic increases tear film stability.

To examine associations between corneal mechanical thresholds and metrics of dry eye.

Corneal Mechanical Thresholds Negatively Associate With Dry Eye and Ocular Pain Symptoms.

To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity.

Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity.

Visual photosensitivity is a common symptom difficult to measure and diagnose, and is found in many ocular and neurological disorders. We developed two novel reproducible quantitative assessments of visual photosensitivity.

New Methods for Quantification of Visual Photosensitivity Threshold and Symptoms.

Our purpose was to develop a robotic remotely operated stereo slit lamp system allowing three-dimensional stereo viewing and recording of the patient's examination via local area network, Internet, and satellite.

Robotic Remote Controlled Stereo Slit Lamp.

We present a new  instrument for measuring shape and wavefront aberrations of the primate crystalline lens, both on- and off-axis, while simulating accommodation with a motorized lens stretching system. The instrument merges spectral domain optical coherence tomography (SD-OCT) imaging and ray tracing aberrometry using an approach that senses wavefront aberrations of the lens with the OCT probing beam. Accuracy and repeatability of aberration measurements were quantified. Preliminary experiments on two human and four cynomolgus monkey lenses demonstrate the ability of the system to measure the lens shape, spherical aberration and peripheral defocus, and their changes during simulated accommodation.

System for on- and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens.

The Ocular Photosensitivity Analyzer (OPA), a new automated instrument to quantify the visual photosensitivity thresholds (VPT) in healthy and light sensitive subjects, is described. The OPA generates light stimuli of varying intensities utilizing unequal ascending and descending steps to yield the VPT. The performance of the OPA was evaluated in healthy subjects, as well as light sensitive subjects with achromatopsia or traumatic brain injury (TBI). VPT in healthy, achromatopsia, and TBI subjects were 3.2 ± 0.6 log lux, 0.5 ± 0.5 log lux, and 0.4 ± 0.6 log lux, respectively. Light sensitive subjects manifested significantly lower VPT compared to healthy subjects. Longitudinal analysis revealed that the OPA reliably measured VPT in healthy subjects.

Article	Year
Cancer incidence among Hispanic children in the United States. Revista panamericana de salud publica = Pan American journal of public health\| PubMed ID: 16105320	2005
Airway vascular endothelial function in healthy smokers without systemic endothelial dysfunction. Chest\| PubMed ID: 23348843	2013
A new, specular reflection-based, precorneal tear film stability measurement technique in a rabbit model: viscoelastic increases tear film stability. Investigative ophthalmology & visual science\| PubMed ID: 24948606	2014
Corneal Mechanical Thresholds Negatively Associate With Dry Eye and Ocular Pain Symptoms. Investigative ophthalmology & visual science\| PubMed ID: 26886896	2016
Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity. Translational vision science & technology\| PubMed ID: 28626602	2017
New Methods for Quantification of Visual Photosensitivity Threshold and Symptoms. Translational vision science & technology\| PubMed ID: 28845363	2017
Robotic Remote Controlled Stereo Slit Lamp. Translational vision science & technology\| PubMed ID: 29977662	2018
System for on- and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens. Biomedical optics express\| PubMed ID: 30338159	2018
Automated instrument designed to determine visual photosensitivity thresholds. Biomedical optics express\| PubMed ID: 30460148	2018

Alex Gonzalez

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