Karla J. Hutt

Development and Stem Cells Program, Monash University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2023
Publication title Cited by 22	2020

Other Publications

Article	Year
Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib. Nature medicine\| PubMed ID: 22869179	2012
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa. Molecular cell\| PubMed ID: 23000175	2012
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts. Molecular oncology\| PubMed ID: 24560445	2014
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice. Biology of reproduction\| PubMed ID: 24571986	2014
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary. Development (Cambridge, England)\| PubMed ID: 25038044	2014
What is the "ovarian reserve"? Fertility and sterility\| PubMed ID: 25500021	2015
Ovarian reserve screening: a scientific and ethical analysis. Human reproduction (Oxford, England)\| PubMed ID: 25637623	2015
How Is the Number of Primordial Follicles in the Ovarian Reserve Established? Biology of reproduction\| PubMed ID: 26423124	2015
BCL2-modifying factor promotes germ cell loss during murine oogenesis. Reproduction (Cambridge, England)\| PubMed ID: 26917450	2016
The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF. Cell death & disease\| PubMed ID: 28771225	2017
The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing. Human reproduction update\| PubMed ID: 29377997	2018
Examination of the ovotoxicity of 5-fluorouracil in mice. Journal of assisted reproduction and genetics\| PubMed ID: 29589294	2018
Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age. Scientific reports\| PubMed ID: 29695822	2018
The capacity of oocytes for DNA repair. Cellular and molecular life sciences : CMLS\| PubMed ID: 29748894	2018
Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility. Cell death & disease\| PubMed ID: 29795269	2018
Maternal low-protein diet programmes low ovarian reserve in offspring Reproduction (Cambridge, England)\| PubMed ID: 29991566	2018
Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 30085306	2018
Oocytes from stem cells. Best practice & research. Clinical obstetrics & gynaecology\| PubMed ID: 30120061	2019
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma. Nature communications\| PubMed ID: 30266954	2018
Maternal low-protein diet programmes low ovarian reserve in offspring Reproduction (Cambridge, England)\| PubMed ID: 30306601	2018
Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 30657998	2019
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. BMJ open\| PubMed ID: 31772111	2019
Do cancer therapies damage the uterus and compromise fertility? Human reproduction update\| PubMed ID: 31863097	2020
Evaluation of mitochondria in oocytes following γ-irradiation. Scientific reports\| PubMed ID: 31882895	2019
Moderate episodic prenatal alcohol does not impact female offspring fertility in rats. Reproduction (Cambridge, England)\| PubMed ID: 32168471	2020
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32381741	2020
The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation. Human reproduction (Oxford, England)\| PubMed ID: 32604417	2020
Comparison of methods for quantifying primordial follicles in the mouse ovary. Journal of ovarian research\| PubMed ID: 33054849	2020
Evaluation of inflammation and follicle depletion during ovarian ageing in mice. Scientific reports\| PubMed ID: 33432051	2021
The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice. Frontiers in cell and developmental biology\| PubMed ID: 33644037	2020
Prolonged atrazine exposure beginning and adult uterine morphology in mice. Journal of developmental origins of health and disease\| PubMed ID: 33781367	2022
DNA repair in primordial follicle oocytes following cisplatin treatment. Journal of assisted reproduction and genetics\| PubMed ID: 33864208	2021
Evaluation of mitochondria in mouse oocytes following cisplatin exposure. Journal of ovarian research\| PubMed ID: 33971923	2021
Assessment of Ovarian Function in Phase III (Neo)Adjuvant Breast Cancer Clinical Trials: A Systematic Evaluation. Journal of the National Cancer Institute\| PubMed ID: 34048575	2021
HENMT1 is involved in the maintenance of normal female fertility in the mouse. Molecular human reproduction\| PubMed ID: 34590701	2021
Development of an embryo transfer model to study uterine contributions to pregnancy in mice. Reproduction & fertility\| PubMed ID: 35198982	2022
Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice. Nature cancer\| PubMed ID: 36008687	2022
Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance. Biochimie\| PubMed ID: 36116742	2022
Does single-strand DNA break repair capacity influence oocyte maintenance and quality? Reproduction (Cambridge, England)\| PubMed ID: 36215096	2022
Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice. Cells\| PubMed ID: 36831314	2023
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life. Human reproduction update\| PubMed ID: 36857094	2023
Radiotherapy exposure directly damages the uterus and causes pregnancy loss. JCI insight\| PubMed ID: 36946464	2023