in-vitro-assessment-myocardial-protection-following-hypothermia

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Ischemia/reperfusion-derived myocardial dysfunction is a common clinical scenario in patients after cardiac surgery. In particular, the sensitivity of ...

Children's Hospital of Nanjing Medical University

Primary cardiac tumors in children are extremely rare. This study aimed to analyze clinical treatment and follow-up of pediatric primary cardiac tumors.

Clinical Treatment of Pediatric Primary Cardiac Tumors: A Single-Institute 12-Year Experience.

 We studied inflammatory marker changes with ultrafiltration extracorporeal techniques and compared these levels to those occurring during conventional techniques.  Seventy-four children undergoing extracorporeal circulation during congenital heart surgery were divided into two groups-conventional (control) and balanced ultrafiltrations (study). Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and soluble intercellular adhesion molecule-1 (sICAM-1), static lung compliance (Cstat), alveolar-arterial oxygen partial pressure difference (A-aDO2), and oxygenation index (OI) were measured.  Thirty minutes after extracorporeal circulation (T1), IL-6 and TNF-α levels significantly increased ( < .05), which plummeted 3 h after surgery (T2). The levels in the study group were lower ( < .05). sICAM-1 levels at T1 and T2 significantly exceeded those at T0, and study group had lower levels ( < .05). At T1, Cstat and OI dropped ( < .05), which increased at T2 ( < .05), and study group had less decreases ( < .05). A-aDO2 at T1 surpassed that before intervention ( < .05), and study group had less increase ( < .05).  Balanced ultrafiltration exerts protective effects on children with congenital heart disease undergoing extracorporeal circulation.

Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response.

Article	Year
Clinical Treatment of Pediatric Primary Cardiac Tumors: A Single-Institute 12-Year Experience. Journal of pediatric hematology/oncology\| PubMed ID: 31162296	2020
Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response. Fetal and pediatric pathology\| PubMed ID: 31514562	2020

Peicheng Ding

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