David L. Sacks

Laboratory of Parasitic Diseases, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2020

Other Publications

Article	Year
Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. The Journal of experimental medicine\| PubMed ID: 9314562	1997
Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. The Journal of experimental medicine\| PubMed ID: 9782133	1998
Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear de... The Journal of experimental medicine\| PubMed ID: 9815271	1998
The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite chall... Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10890924	2000
Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. The Journal of experimental medicine\| PubMed ID: 11489952	2001
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. The Journal of experimental medicine\| PubMed ID: 11714756	2001
Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection agains... The Journal of experimental medicine\| PubMed ID: 12070284	2002
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature\| PubMed ID: 12466842	2002
Immunological and pathological evaluation of rhesus macaques infected with Leishmania major. Experimental parasitology\| PubMed ID: 12880593	2003
Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability. Infection and immunity\| PubMed ID: 12933855	2003
Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15728505	2005
Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection. Infection and immunity\| PubMed ID: 16040984	2005
Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs. Infection and immunity\| PubMed ID: 16041009	2005
Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells. Infection and immunity\| PubMed ID: 16177338	2005
A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. The Journal of experimental medicine\| PubMed ID: 17000865	2006
Uninfected mosquito bites confer protection against infection with malaria parasites. Infection and immunity\| PubMed ID: 17339356	2007
Vector transmission of leishmania abrogates vaccine-induced protective immunity. PLoS pathogens\| PubMed ID: 19543375	2009
The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis. Cellular microbiology\| PubMed ID: 19545276	2009
Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern. PLoS pathogens\| PubMed ID: 21085609	2010
Infection parameters in the sand fly vector that predict transmission of Leishmania major. PLoS neglected tropical diseases\| PubMed ID: 21886852	2011
Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23045616	2012
Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice. European journal of immunology\| PubMed ID: 23109292	2013
Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major. Infection and immunity\| PubMed ID: 24733090	2014
Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem. Nature immunology\| PubMed ID: 24747701	2014
Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25385616	2014
Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. PLoS pathogens\| PubMed ID: 25473946	2014
Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26371247	2015
The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice. European journal of immunology\| PubMed ID: 26689285	2016
The Transcriptome of Developmental Stages in Their Natural Sand Fly Vector. mBio\| PubMed ID: 28377524	2017
Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major. PLoS pathogens\| PubMed ID: 28666021	2017
Gene Expression in Is Regulated Predominantly by Gene Dosage. mBio\| PubMed ID: 28900023	2017
NOX2-Derived Reactive Oxygen Species Control Inflammation during Infection by Mediating Infection-Induced Neutrophil Apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29158417	2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing infection in a Th1 immune environment. The Journal of experimental medicine\| PubMed ID: 29247046	2018
Inflammasomes and Leishmania: in good times or bad, in sickness or in health. Current opinion in microbiology\| PubMed ID: 31229882	2019
CRISPR/Cas9 Mutagenesis in Phlebotomus papatasi: the Immune Deficiency Pathway Impacts Vector Competence for Leishmania major. mBio\| PubMed ID: 31455654	2019
M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Science immunology\| PubMed ID: 32276966	2020
The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis. Cell host & microbe\| PubMed ID: 32407702	2020