Howard S. Fox

Department of Neurological Sciences, University of Nebraska Medical Center

Affiliated withUniversity of Nebraska Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2021

Other Publications

Article	Year
Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity. Autophagy\| PubMed ID: 18772620	2008
Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys. Journal of proteome research\| PubMed ID: 19281240	2009
Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 19757077	2010
An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19812322	2009
A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection. Neuron\| PubMed ID: 19840555	2009
Quantitative plasma proteomic profiling identifies the vitamin E binding protein afamin as a potential pathogenic factor in SIV induced CNS disease. Journal of proteome research\| PubMed ID: 19908921	2010
Advances in the "omics" for diagnosis, pathogenesis, and therapeutic development. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20143174	2010
Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders. Genome medicine\| PubMed ID: 20353544	2010
Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques. Journal of proteome research\| PubMed ID: 20677826	2010
Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity. AIDS research and human retroviruses\| PubMed ID: 20929344	2011
Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine\| PubMed ID: 20960269	2010
Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage. Journal of proteome research\| PubMed ID: 21500866	2011
Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism. Molecular neurodegeneration\| PubMed ID: 21777416	2011
Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques. Drug and alcohol dependence\| PubMed ID: 21821369	2012
Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment. Biochemical and biophysical research communications\| PubMed ID: 22142844	2012
Translating the brain transcriptome in neuroAIDS: from non-human primates to humans. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22367717	2012
Commentary: Animal models of neuroAIDS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22549136	2012
Comparison of 4-plex to 8-plex iTRAQ quantitative measurements of proteins in human plasma samples. Journal of proteome research\| PubMed ID: 22594965	2012
Methamphetamine and inflammatory cytokines increase neuronal Na+/K+-ATPase isoform 3: relevance for HIV associated neurocognitive disorders. PloS one\| PubMed ID: 22662178	2012
Protective role for the disulfide isomerase PDIA3 in methamphetamine neurotoxicity. PloS one\| PubMed ID: 22715419	2012
The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment. PloS one\| PubMed ID: 23049970	2012
N-methyl-D-aspartate receptor-mediated axonal injury in adult rat corpus callosum. Journal of neuroscience research\| PubMed ID: 23161705	2013
Methamphetamine administration targets multiple immune subsets and induces phenotypic alterations suggestive of immunosuppression. PloS one\| PubMed ID: 23227154	2012
Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy. Antimicrobial agents and chemotherapy\| PubMed ID: 23612193	2013
Functional brain abnormalities during finger-tapping in HIV-infected older adults: a magnetoencephalography study. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 23749418	2013
Up-regulation of microRNA-142 in simian immunodeficiency virus encephalitis leads to repression of sirtuin1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23752207	2013
Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer's disease. BMC systems biology\| PubMed ID: 23803348	2013
Abnormal MEG oscillatory activity during visual processing in the prefrontal cortices and frontal eye-fields of the aging HIV brain. PloS one\| PubMed ID: 23840428	2013
Pilot study of younger and older HIV-infected adults using traditional and novel functional assessments. HIV clinical trials\| PubMed ID: 23924589	2013
Autophagy-mediated turnover of dynamin-related protein 1. BMC neuroscience\| PubMed ID: 23937156	2013
Quantitative proteomics reveals oxygen-dependent changes in neuronal mitochondria affecting function and sensitivity to rotenone. Journal of proteome research\| PubMed ID: 23971408	2013
Combined fluorescent in situ hybridization for detection of microRNAs and immunofluorescent labeling for cell-type markers. Frontiers in cellular neuroscience\| PubMed ID: 24065888	2013
MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1. PloS one\| PubMed ID: 24244526	2013
Biomarkers for NeuroAIDS: recent progress in the field. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24292958	2013
Decreased MEG beta oscillations in HIV-infected older adults during the resting state. Journal of neurovirology\| PubMed ID: 24297500	2013
Quantitative proteomics by SWATH-MS reveals altered expression of nucleic acid binding and regulatory proteins in HIV-1-infected macrophages. Journal of proteome research\| PubMed ID: 24564501	2014
The 20th scientific conference of the Society on NeuroImmune Pharmacology. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24573530	2014
Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability. Journal of proteome research\| PubMed ID: 24708184	2014
Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24789373	2014
Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. Aging\| PubMed ID: 24827396	2014
CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system. The Journal of infectious diseases\| PubMed ID: 25035516	2015
Proteomic analysis of the mitochondria from embryonic and postnatal rat brains reveals response to developmental changes in energy demands. Journal of proteomics\| PubMed ID: 25046836	2014
Efavirenz induces neuronal autophagy and mitochondrial alterations. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25161171	2014
Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations. Antimicrobial agents and chemotherapy\| PubMed ID: 25288084	2014
Enhanced methamphetamine metabolism in rhesus macaque as compared with human: an analysis using a novel method of liquid chromatography with tandem mass spectrometry, kinetic study, and subs... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 25301936	2014
A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Biology direct\| PubMed ID: 25319552	2014
Multimodal neuroimaging evidence of alterations in cortical structure and function in HIV-infected older adults. Human brain mapping\| PubMed ID: 25376125	2015
Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats. Molecular neurobiology\| PubMed ID: 25421206	2016
Brain region mapping using global metabolomics. Chemistry & biology\| PubMed ID: 25457182	2014
Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin. Mediators of inflammation\| PubMed ID: 25525298	2014
Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism. Proteomics\| PubMed ID: 25546256	2015
Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse. Journal of neurovirology\| PubMed ID: 26037114	2015
MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease. PLoS pathogens\| PubMed ID: 26154133	2015
Data for mitochondrial proteomic alterations in the developing rat brain. Data in brief\| PubMed ID: 26217684	2014
Data for mitochondrial proteomic alterations in the aging mouse brain. Data in brief\| PubMed ID: 26217775	2015
The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies. Database : the journal of biological databases and curation\| PubMed ID: 26228431	2015
Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system. Frontiers in microbiology\| PubMed ID: 26441851	2015
Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells. BioMed research international\| PubMed ID: 26539539	2015
Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB. Alcoholism, clinical and experimental research\| PubMed ID: 26556759	2015
The Proteomic Characterization of Plasma or Serum from HIV-Infected Patients. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26714720	2016
HIV-1 transgenic rats display mitochondrial abnormalities consistent with abnormal energy generation and distribution. Journal of neurovirology\| PubMed ID: 26843384	2016
Neonatal mitochondrial abnormalities due to PINK1 deficiency: Proteomics reveals early changes relevant to Parkinson׳s disease. Data in brief\| PubMed ID: 26866053	2016
Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA. Molecular cell\| PubMed ID: 27105112	2016
Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets. BMC immunology\| PubMed ID: 27107567	2016
Metabolic drift in the aging brain. Aging\| PubMed ID: 27182841	2016
Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation. FEBS open bio\| PubMed ID: 27516962	2016
Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respirat... Proteomics. Clinical applications\| PubMed ID: 27568932	2016
SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria. Data in brief\| PubMed ID: 27761515	2016
Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications. Cell death & disease\| PubMed ID: 27882942	2016
Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain. Scientific reports\| PubMed ID: 28155864	2017
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 28236278	2017
Measures of Physical and Mental Independence Among HIV-Positive Individuals: Impact of Substance Use Disorder. AIDS research and human retroviruses\| PubMed ID: 28288515	2017
Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect. Frontiers in molecular neuroscience\| PubMed ID: 28804446	2017
Osteopontin Impacts Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators of inflammation\| PubMed ID: 28811681	2017
Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals. Journal of neurovirology\| PubMed ID: 28895059	2017
Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials\| PubMed ID: 29059541	2018
Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques. Antimicrobial agents and chemotherapy\| PubMed ID: 29061742	2018
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 29280055	2018
Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics\| PubMed ID: 29290806	2018
Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment. Brain : a journal of neurology\| PubMed ID: 29672678	2018
Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis. Oncotarget\| PubMed ID: 29719633	2018
Aberrant oscillatory dynamics during somatosensory processing in HIV-infected adults. NeuroImage. Clinical\| PubMed ID: 30094159	2018
Proteomic and functional data sets on synaptic mitochondria from rats with genetic ablation of . Data in brief\| PubMed ID: 30197913	2018
Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques. AIDS (London, England)\| PubMed ID: 30289818	2019
Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder. Neurology\| PubMed ID: 30333162	2018
The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research. Database : the journal of biological databases and curation\| PubMed ID: 30624650	2019
A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis. Epilepsia\| PubMed ID: 30740690	2019
Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development. Developmental neurobiology\| PubMed ID: 31050203	2019
Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder. Stem cells international\| PubMed ID: 31191687	2019
Secreted Metabolome of Human Macrophages Exposed to Methamphetamine. Analytical chemistry\| PubMed ID: 31265257	2019
Creation of a long-acting rilpivirine prodrug nanoformulation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 31491432	2019
Epigenetic Markers of Aging Predict the Neural Oscillations Serving Selective Attention. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 31504270	2020
Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS. AIDS (London, England)\| PubMed ID: 31790376	2019
Age-related visual dynamics in HIV-infected adults with cognitive impairment. Neurology(R) neuroimmunology & neuroinflammation\| PubMed ID: 32102916	2020
Interactive effects of HIV and ageing on neural oscillations: independence from neuropsychological performance. Brain communications\| PubMed ID: 32322820	2020
A year-long extended release nanoformulated cabotegravir prodrug. Nature materials\| PubMed ID: 32341511	2020
HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis. PLoS biology\| PubMed ID: 32453744	2020
Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities. mBio\| PubMed ID: 32723919	2020
Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse. Scientific reports\| PubMed ID: 32792613	2020
Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop. Pathogens & immunity\| PubMed ID: 32856008	2020
Association of Epigenetic Metrics of Biological Age With Cortical Thickness. JAMA network open\| PubMed ID: 32926115	2020
Prefrontal gating of sensory input differentiates cognitively impaired and unimpaired aging adults with HIV. Brain communications\| PubMed ID: 32954330	2020
Pharmacologic approaches to HIV-associated neurocognitive disorders. Current opinion in pharmacology\| PubMed ID: 33049585	2020
The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study. EBioMedicine\| PubMed ID: 33099087	2020
Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis. Viruses\| PubMed ID: 33198269	2020
Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model. Journal of virology\| PubMed ID: 33328304	2020