Robert J. Crouch

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 39	2021

Other Publications

Article	Year
Isolation of RNase H genes that are essential for growth of Bacillus subtilis 168. Journal of bacteriology\| PubMed ID: 10094689	1999
Quantitative regulation of class switch recombination by switch region transcription. The Journal of experimental medicine\| PubMed ID: 11489955	2001
Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Molecular biology and evolution\| PubMed ID: 12411600	2002
Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Molecular cell\| PubMed ID: 12667461	2003
RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic acids research\| PubMed ID: 14734815	2004
Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain. Nucleic acids research\| PubMed ID: 15831789	2005
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell\| PubMed ID: 15989951	2005
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Molecular cell\| PubMed ID: 17964265	2007
Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. The EMBO journal\| PubMed ID: 18337749	2008
Ribonuclease H: the enzymes in eukaryotes. The FEBS journal\| PubMed ID: 19228196	2009
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. Journal of molecular biology\| PubMed ID: 20184890	2010
An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Molecular and cellular biology\| PubMed ID: 20823270	2010
Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage. Molecular cell\| PubMed ID: 21095591	2010
The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. The Journal of biological chemistry\| PubMed ID: 21177858	2011
Molecular biology. A new twist for topoisomerase. Science (New York, N.Y.)\| PubMed ID: 21700860	2011
Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Molecular and cellular biology\| PubMed ID: 24190965	2014
Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26162680	2015
Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae. DNA repair\| PubMed ID: 26340535	2015
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. The Journal of experimental medicine\| PubMed ID: 26880576	2016
The Balancing Act of Ribonucleotides in DNA. Trends in biochemical sciences\| PubMed ID: 26996833	2016
Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27402764	2016
R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching. Journal of molecular biology\| PubMed ID: 28065739	2017
Effects of neutral salts and pH on the activity and stability of human RNase H2. Journal of biochemistry\| PubMed ID: 28402412	2017
Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2. Nucleic acids research\| PubMed ID: 28977421	2017
Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development. Cell reports\| PubMed ID: 30380406	2018
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer. PLoS genetics\| PubMed ID: 31125342	2019
Unlike the counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA. The Journal of biological chemistry\| PubMed ID: 31300556	2019
Characterization of six recombinant human RNase H2 bearing Aicardi-Goutiéres syndrome causing mutations. Journal of biochemistry\| PubMed ID: 31529068	2019
RNases H: Multiple roles in maintaining genome integrity. DNA repair\| PubMed ID: 31708455	2019
RNase H2-RED carpets the path to eukaryotic RNase H2 functions. DNA repair\| PubMed ID: 31761672	2019
Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity. PloS one\| PubMed ID: 32069311	2020
High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase. Nucleic acids research\| PubMed ID: 32187369	2020