Frank J.T Staal

Department of Immunology, Leiden University Medical Center

Affiliated withLeiden University Medical Center Leiden University Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2021

Other Publications

Article	Year
Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress? Antioxidants & redox signaling\| PubMed ID: 16356109	2005
Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisions. Journal of cellular biochemistry\| PubMed ID: 20069555	2010
Genome-wide expression analysis of paired diagnosis-relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phen... Leukemia\| PubMed ID: 20072147	2010
Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia\| PubMed ID: 21527933	2011
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia\| PubMed ID: 22173215	2012
Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype. Diabetes\| PubMed ID: 22228716	2012
Wnt cross-talk in the niche. Blood\| PubMed ID: 22343661	2012
Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure? Pediatric research\| PubMed ID: 22430378	2012
Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches. Annals of the New York Academy of Sciences\| PubMed ID: 22901260	2012
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. Immunity\| PubMed ID: 23159221	2012
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS biology\| PubMed ID: 23185135	2012
Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in human... Diabetologia\| PubMed ID: 24030068	2013
Wnt signaling in leukemias and myeloma: T-cell factors are in control. Future oncology (London, England)\| PubMed ID: 24156335	2013
Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24610930	2014
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis. Genome research\| PubMed ID: 24760347	2014
Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice. BioResearch open access\| PubMed ID: 24940562	2014
TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 24994854	2014
Successful RAG1-SCID gene therapy depends on the level of RAG1 expression. The Journal of allergy and clinical immunology\| PubMed ID: 25117803	2014
T Cell factor 1 represses CD8+ effector T cell formation and function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25355919	2014
Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells. The Journal of allergy and clinical immunology\| PubMed ID: 26441229	2016
The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26453748	2015
Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26483497	2015
Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model. Stem cells and development\| PubMed ID: 26650921	2016
The functional relationship between hematopoietic stem cells and developing T lymphocytes. Annals of the New York Academy of Sciences\| PubMed ID: 26773328	2016
Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis. Experimental hematology\| PubMed ID: 27016274	2016
High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells. Stem cell reports\| PubMed ID: 27167156	2016
Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms. Experimental hematology\| PubMed ID: 27302866	2016
Aberrant Wnt Signaling in Leukemia. Cancers\| PubMed ID: 27571104	2016
Wnt signalling meets epigenetics. Stem cell investigation\| PubMed ID: 27668245	2016
Wnt Signaling as Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy. Transplantation\| PubMed ID: 27861287	2016
Loss of CD44 Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus. Frontiers in immunology\| PubMed ID: 28163708	2017
Activation of the oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 28270453	2017
The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice. International journal of molecular sciences\| PubMed ID: 28792474	2017
Axin2-mTurquoise2: A novel reporter mouse model for the detection of canonical Wnt signalling. Genesis (New York, N.Y. : 2000)\| PubMed ID: 28875532	2017
B-1 cells and B-1 cell precursors prompt different responses to Wnt signaling. PloS one\| PubMed ID: 29928002	2018
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine\| PubMed ID: 29941549	2018
Cell intrinsic regulation of external hematopoietic stem cell stress. Stem cell investigation\| PubMed ID: 29984225	2018
Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche. Cells\| PubMed ID: 30781676	2019
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes. Nature communications\| PubMed ID: 30894540	2019
De novo generation of a functional human thymus from induced pluripotent stem cells. The Journal of allergy and clinical immunology\| PubMed ID: 31323248	2019
ImSpectR - R package to quantify immune repertoire diversity in spectratype and repertoire sequencing data. Bioinformatics (Oxford, England)\| PubMed ID: 31665245	2019
Autologous Stem-Cell-Based Gene Therapy for Inherited Disorders: State of the Art and Perspectives. Frontiers in pediatrics\| PubMed ID: 31737588	2019
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Cancer cell\| PubMed ID: 31935371	2020
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests. Stem cell reports\| PubMed ID: 31956083	2020
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. Cell metabolism\| PubMed ID: 32268117	2020
Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID. Molecular therapy. Methods & clinical development\| PubMed ID: 32322605	2020
Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side. Pharmaceutics\| PubMed ID: 32545727	2020
Functional definition of a transcription factor hierarchy regulating T cell lineage commitment. Science advances\| PubMed ID: 32789164	2020
An adequate human T cell repertoire from a single T cell progenitor: Lessons from an experiment of nature. EBioMedicine\| PubMed ID: 32977163	2020
Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective. Frontiers in immunology\| PubMed ID: 33042151	2020
Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells. Cells\| PubMed ID: 33050292	2020
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian. Leukemia\| PubMed ID: 33184493	2021
A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes. Frontiers in immunology\| PubMed ID: 33584681	2020
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy? Frontiers in cell and developmental biology\| PubMed ID: 33614624	2020
Corrigendum: Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective. Frontiers in immunology\| PubMed ID: 33936092	2021
The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors. Cells\| PubMed ID: 33946533	2021
Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation. Cells\| PubMed ID: 33946560	2021
A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors. Cellular & molecular immunology\| PubMed ID: 34117371	2021
Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 34174440	2021