Stephen P. Muench

School of Biomedical Sciences, University of Leeds

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2021

Other Publications

Article	Year
Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity. Journal of molecular biology\| PubMed ID: 19244615	2009
Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans. Vaccine\| PubMed ID: 20347630	2010
Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase. The Journal of biological chemistry\| PubMed ID: 20884613	2010
T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest. PloS one\| PubMed ID: 21124925	2010
Structural divergence of the rotary ATPases. Quarterly reviews of biophysics\| PubMed ID: 21426606	2011
Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrobial agents and chemotherapy\| PubMed ID: 22354304	2012
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorganic & medicinal chemistry letters\| PubMed ID: 23453069	2013
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorganic & medicinal chemistry letters\| PubMed ID: 23664871	2013
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. ChemMedChem\| PubMed ID: 23776166	2013
Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPase. Journal of molecular biology\| PubMed ID: 24075871	2014
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry\| PubMed ID: 24295325	2013
Flexibility within the rotor and stators of the vacuolar H+-ATPase. PloS one\| PubMed ID: 24312643	2013
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorganic & medicinal chemistry letters\| PubMed ID: 24398298	2014
ALOX12 in human toxoplasmosis. Infection and immunity\| PubMed ID: 24686056	2014
PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism. The Journal of biological chemistry\| PubMed ID: 24795045	2014
Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers. International journal of molecular sciences\| PubMed ID: 25079442	2014
Understanding the apparent stator-rotor connections in the rotary ATPase family using coarse-grained computer modeling. Proteins\| PubMed ID: 25174610	2014
The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy. Biochimica et biophysica acta\| PubMed ID: 25450810	2015
The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis. Protist\| PubMed ID: 25576842	2015
Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights. Structure (London, England : 1993)\| PubMed ID: 25661654	2015
Replace, reuse, recycle: improving the sustainable use of phosphorus by plants. Journal of experimental botany\| PubMed ID: 25944926	2015
Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. British journal of pharmacology\| PubMed ID: 26045093	2015
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human. Bioorganic & medicinal chemistry letters\| PubMed ID: 26099538	2015
In situ formation of magnetopolymersomes via electroporation for MRI. Scientific reports\| PubMed ID: 26391797	2015
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes. The Journal of biological chemistry\| PubMed ID: 26912656	2016
An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology. Methods (San Diego, Calif.)\| PubMed ID: 26931652	2016
Methods to account for movement and flexibility in cryo-EM data processing. Methods (San Diego, Calif.)\| PubMed ID: 27016144	2016
Editorial. Methods (San Diego, Calif.)\| PubMed ID: 27060404	2016
Characterization of the flexibility of the peripheral stalk of prokaryotic rotary A-ATPases by atomistic simulations. Proteins\| PubMed ID: 27177595	2016
Corrigendum to 'Methods to account for movement and flexibility in cryo-EM data processing' [Methods 100 (2016) 35-41]. Methods (San Diego, Calif.)\| PubMed ID: 27209563	2016
A method for detergent-free isolation of membrane proteins in their local lipid environment. Nature protocols\| PubMed ID: 27254461	2016
Pi sensing and signalling: from prokaryotic to eukaryotic cells. Biochemical Society transactions\| PubMed ID: 27284040	2016
Rotating with the brakes on and other unresolved features of the vacuolar ATPase. Biochemical Society transactions\| PubMed ID: 27284051	2016
The varied functions of aluminium-activated malate transporters-much more than aluminium resistance. Biochemical Society transactions\| PubMed ID: 27284052	2016
Artificial membranes for membrane protein purification, functionality and structure studies. Biochemical Society transactions\| PubMed ID: 27284055	2016
Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists. Biochemical pharmacology\| PubMed ID: 27481062	2016
Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology. Chemical communications (Cambridge, England)\| PubMed ID: 27540604	2016
The changing landscape of membrane protein structural biology through developments in electron microscopy. Molecular membrane biology\| PubMed ID: 27608730	2016
The conservation of phosphate-binding residues among PHT1 transporters suggests that distinct transport affinities are unlikely to result from differences in the phosphate-binding site. Biochemical Society transactions\| PubMed ID: 27911737	2016
Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies. Purinergic signalling\| PubMed ID: 28025718	2017
Durable vesicles for reconstitution of membrane proteins in biotechnology. Biochemical Society transactions\| PubMed ID: 28202656	2017
Everyone needs good neighbours - the intricate relationship between the acetylcholine-receptor channel and its membrane environment. IUCrJ\| PubMed ID: 28875018	2017
AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. The Biochemical journal\| PubMed ID: 28887383	2017
Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure. Biochimica et biophysica acta\| PubMed ID: 28993151	2018
A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability. Methods (San Diego, Calif.)\| PubMed ID: 29410153	2018
Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29434040	2018
No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases. Molecular cell\| PubMed ID: 29547720	2018
X-ray and cryo-EM structures of inhibitor-bound cytochrome complexes for structure-based drug discovery. IUCrJ\| PubMed ID: 29765610	2018
Approaches to altering particle distributions in cryo-electron microscopy sample preparation. Acta crystallographica. Section D, Structural biology\| PubMed ID: 29872006	2018
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nature structural & molecular biology\| PubMed ID: 29915388	2018
CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in . Frontiers in cellular and infection microbiology\| PubMed ID: 30345257	2018
Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies. Biochemical Society transactions\| PubMed ID: 30514765	2018
The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM. IUCrJ\| PubMed ID: 30867914	2019
SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 31150633	2019
LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. Acta crystallographica. Section D, Structural biology\| PubMed ID: 31282475	2019
Emerging Role of Electron Microscopy in Drug Discovery. Trends in biochemical sciences\| PubMed ID: 31409563	2019
Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy. Science advances\| PubMed ID: 31489376	2019
Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. Cell\| PubMed ID: 31543266	2019
A cryo-EM grid preparation device for time-resolved structural studies. IUCrJ\| PubMed ID: 31709058	2019
Styrene maleic acid recovers proteins from mammalian cells and tissues while avoiding significant cell death. Scientific reports\| PubMed ID: 31767876	2019
Unprecedented Properties of Phenothiazines Unraveled by a NDH-2 Bioelectrochemical Assay Platform. Journal of the American Chemical Society\| PubMed ID: 31880924	2020
Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 31945320	2020
Sample deposition onto cryo-EM grids: from sprays to jets and back. Acta crystallographica. Section D, Structural biology\| PubMed ID: 32254058	2020
Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites. PLoS pathogens\| PubMed ID: 32271834	2020
Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K1.1 (KCNT1) Potassium Channel. iScience\| PubMed ID: 32408169	2020
The active form of quinol-dependent nitric oxide reductase from is a dimer. IUCrJ\| PubMed ID: 32431824	2020
Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from . Microorganisms\| PubMed ID: 32585951	2020
Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Frontiers in cellular and infection microbiology\| PubMed ID: 32626661	2020
Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales. Structure (London, England : 1993)\| PubMed ID: 32814033	2020
Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors. Purinergic signalling\| PubMed ID: 33029714	2020
Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. Communications biology\| PubMed ID: 33230284	2020
Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy. Biomolecules\| PubMed ID: 33333800	2020
Cryo-EM structure of human mitochondrial HSPD1. iScience\| PubMed ID: 33506187	2021
Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis. Nature communications\| PubMed ID: 34001871	2021
Targeting K1.1 channels in KCNT1-associated epilepsy. Trends in pharmacological sciences\| PubMed ID: 34074526	2021
On-grid and in-flow mixing for time-resolved cryo-EM. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34605427	2021
Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins\| PubMed ID: 34622987	2021