Joel Gottesfeld

Department of Molecular Biology, The Scripps Research Institute

Affiliated withThe Scripps Research Institute

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2012

Other Publications

Article	Year
Promoter scanning for transcription inhibition with DNA-binding polyamides. Molecular and cellular biology\| PubMed ID: 11865052	2002
Cyclin L is an RS domain protein involved in pre-mRNA splicing. The Journal of biological chemistry\| PubMed ID: 11980906	2002
Blocking transcription through a nucleosome with synthetic DNA ligands. Journal of molecular biology\| PubMed ID: 12144782	2002
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. Journal of molecular biology\| PubMed ID: 12559907	2003
RNA as a transcriptional activator. Chemistry & biology\| PubMed ID: 12890529	2003
Accessibility of nuclear chromatin by DNA binding polyamides. Chemistry & biology\| PubMed ID: 14522056	2003
Molecular recognition of the nucleosomal "supergroove". Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15100411	2004
Regulation of gene expression with pyrrole-imidazole polyamides. Journal of biotechnology\| PubMed ID: 15288953	2004
Arresting cancer proliferation by small-molecule gene regulation. Chemistry & biology\| PubMed ID: 15556009	2004
Nucleosomes in solution exist as a mixture of twist-defect states. Journal of molecular biology\| PubMed ID: 15567414	2005
Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains. Chembiochem : a European journal of chemical biology\| PubMed ID: 15593070	2005
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry\| PubMed ID: 15766247	2005
Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA. Journal of molecular biology\| PubMed ID: 16405997	2006
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin. Nature chemical biology\| PubMed ID: 16415862	2006
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16857735	2006
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16861886	2006
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nature chemical biology\| PubMed ID: 16921367	2006
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic acids research\| PubMed ID: 17170006	2007
Small molecules affecting transcription in Friedreich ataxia. Pharmacology & therapeutics\| PubMed ID: 17826840	2007
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Molecular cancer therapeutics\| PubMed ID: 18413791	2008
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PloS one\| PubMed ID: 18463734	2008
Targeting specific gene by alkylating pyrrole-imidazole polyamides. Nucleic acids symposium series (2004)\| PubMed ID: 18776404	2008
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18829438	2008
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. The Journal of biological chemistry\| PubMed ID: 18953021	2008
Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate. PloS one\| PubMed ID: 18974832	2008
Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 19362838	2009
Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chemistry & biology\| PubMed ID: 19778726	2009
Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes. Bioorganic & medicinal chemistry\| PubMed ID: 19962902	2010
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nature chemical biology\| PubMed ID: 19966789	2010
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model. PloS one\| PubMed ID: 20098685	2010
Chemical biology meets biological chemistry minireview series. The Journal of biological chemistry\| PubMed ID: 20147295	2010
Development of histone deacetylase inhibitors as therapeutics for neurological disease. Future neurology\| PubMed ID: 20177429	2009
Friedreich's ataxia induced pluripotent stem cells model intergenerational GAAâ‹…TTC triplet repeat instability. Cell stem cell\| PubMed ID: 21040903	2010
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell stem cell\| PubMed ID: 21211785	2011
Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model. Neurobiology of disease\| PubMed ID: 21397024	2011
Introduction to the thematic minireview series on epigenetics. The Journal of biological chemistry\| PubMed ID: 21454488	2011
Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21913121	2011
A gene expression phenotype in lymphocytes from Friedreich ataxia patients. Annals of neurology\| PubMed ID: 22162061	2011