George Harauz

Department of Molecular and Cellular Biology, University of Guelph

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2012

Other Publications

Article	Year
The formation of helical tubular vesicles by binary monolayers containing a nickel-chelating lipid and phosphoinositides in the presence of basic polypeptides. Chemistry and physics of lipids\| PubMed ID: 11841829	2002
An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis. Protein expression and purification\| PubMed ID: 12135568	2002
Interactions of the 18.5-kDa isoform of myelin basic protein with Ca(2+)-calmodulin: in vitro studies using fluorescence microscopy and spectroscopy. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 12234092	2002
Interactions of the 18.5 kDa isoform of myelin basic protein with Ca2+-calmodulin: in vitro studies using gel shift assays. Molecular and cellular biochemistry\| PubMed ID: 12482024	2002
Expression and properties of the recombinant murine Golli-myelin basic protein isoform J37. Journal of neuroscience research\| PubMed ID: 12605403	2003
Terminal deletion mutants of myelin basic protein: new insights into self-association and phospholipid interactions. Micron (Oxford, England : 1993)\| PubMed ID: 12694855	2003
Membrane-anchoring and charge effects in the interaction of myelin basic protein with lipid bilayers studied by site-directed spin labeling. The Journal of biological chemistry\| PubMed ID: 12748174	2003
Interaction of the 18.5-kD isoform of myelin basic protein with Ca2+ -calmodulin: effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and ci... Protein science : a publication of the Protein Society\| PubMed ID: 12824496	2003
Molecular dynamics exposes alpha-helices in myelin basic protein. Journal of molecular modeling\| PubMed ID: 12898292	2003
Myelin basic protein has multiple calmodulin-binding sites. Biochemical and biophysical research communications\| PubMed ID: 12901870	2003
Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. The Journal of biological chemistry\| PubMed ID: 14522970	2003
An immunodominant epitope of myelin basic protein is an amphipathic alpha-helix. The Journal of biological chemistry\| PubMed ID: 14630913	2004
Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis. Micron (Oxford, England : 1993)\| PubMed ID: 15219899	2004
Backbone resonance assignments of the 18.5 kDa isoform of murine myelin basic protein (MBP). Journal of biomolecular NMR\| PubMed ID: 15243191	2004
Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP C... Journal of structural biology\| PubMed ID: 15522783	2004
Charge effects modulate actin assembly by classic myelin basic protein isoforms. Biochemical and biophysical research communications\| PubMed ID: 15721315	2005
Effect of arginine loss in myelin basic protein, as occurs in its deiminated charge isoform, on mediation of actin polymerization and actin binding to a lipid membrane in vitro. Biochemistry\| PubMed ID: 15736962	2005
Regulation of fish gill Na(+)-K(+)-ATPase by selective sulfatide-enriched raft partitioning during seawater adaptation. The Journal of biological chemistry\| PubMed ID: 16096276	2005
Assembly of tubulin by classic myelin basic protein isoforms and regulation by post-translational modification. Biochemistry\| PubMed ID: 16342957	2005
Solution NMR structure of an immunodominant epitope of myelin basic protein. Conformational dependence on environment of an intrinsically unstructured protein. The FEBS journal\| PubMed ID: 16420483	2006
Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537438	2006
Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity. The Journal of biological chemistry\| PubMed ID: 16651261	2006
A tale of two citrullines--structural and functional aspects of myelin basic protein deimination in health and disease. Neurochemical research\| PubMed ID: 16900293	2007
White matter rafting--membrane microdomains in myelin. Neurochemical research\| PubMed ID: 17031566	2007
Purification and spectroscopic characterization of the recombinant BG21 isoform of murine golli myelin basic protein. Journal of neuroscience research\| PubMed ID: 17131428	2007
Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 17215885	2006
Molecular "negativity" may underlie multiple sclerosis: role of the myelin basic protein family in the pathogenesis of MS. International review of neurobiology\| PubMed ID: 17531841	2007
The BG21 isoform of Golli myelin basic protein is intrinsically disordered with a highly flexible amino-terminal domain. Biochemistry\| PubMed ID: 17676872	2007
Solid-state NMR spectroscopy of 18.5 kDa myelin basic protein reconstituted with lipid vesicles: spectroscopic characterisation and spectral assignments of solvent-exposed protein fragments. Biochimica et biophysica acta\| PubMed ID: 17920035	2007
Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modificati... Biochemistry\| PubMed ID: 18067320	2008
Dipolar chemical shift correlation spectroscopy for homonuclear carbon distance measurements in proteins in the solid state: application to structure determination and refinement. Journal of the American Chemical Society\| PubMed ID: 18072776	2008
Backbone dynamics of the 18.5 kDa isoform of myelin basic protein reveals transient alpha-helices and a calmodulin-binding site. Biophysical journal\| PubMed ID: 18326633	2008
Solution NMR and CD spectroscopy of an intrinsically disordered, peripheral membrane protein: evaluation of aqueous and membrane-mimetic solvent conditions for studying the conformational ad... European biophysics journal : EBJ\| PubMed ID: 18449534	2008
Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP)--characterization of its phosphatase activity and interaction with Golli-BG21. Protein expression and purification\| PubMed ID: 18625321	2008
Myelin basic protein as a "PI(4,5)P2-modulin": a new biological function for a major central nervous system protein. Biochemistry\| PubMed ID: 18767817	2008
Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 18923545	2008
Myelin basic protein co-distributes with other PI(4,5)P2-sequestering proteins in Triton X-100 detergent-resistant membrane microdomains. Neuroscience letters\| PubMed ID: 19026719	2009
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Disease models & mechanisms\| PubMed ID: 19093029	2008
Induced secondary structure and polymorphism in an intrinsically disordered structural linker of the CNS: solid-state NMR and FTIR spectroscopy of myelin basic protein bound to actin. Biophysical journal\| PubMed ID: 19134474	2009
Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro. Biochemistry\| PubMed ID: 19178193	2009
The classic basic protein of myelin--conserved structural motifs and the dynamic molecular barcode involved in membrane adhesion and protein-protein interactions. Current protein & peptide science\| PubMed ID: 19519451	2009
NMR assignment of an intrinsically disordered protein under physiological conditions: the 18.5 kDa isoform of murine myelin basic protein. Biomolecular NMR assignments\| PubMed ID: 19636827	2007
Structural polymorphism and multifunctionality of myelin basic protein. Biochemistry\| PubMed ID: 19642704	2009
Divalent cations induce a compaction of intrinsically disordered myelin basic protein. Biochemical and biophysical research communications\| PubMed ID: 19903451	2010
Misincorporation of the proline homologue Aze (azetidine-2-carboxylic acid) into recombinant myelin basic protein. Phytochemistry\| PubMed ID: 20064647	2010
The interaction of zinc with membrane-associated 18.5 kDa myelin basic protein: an attenuated total reflectance-Fourier transform infrared spectroscopic study. Amino acids\| PubMed ID: 20169373	2010
Fuzzy complexes of myelin basic protein: NMR spectroscopic investigations of a polymorphic organizational linker of the central nervous system. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 20453917	2010
Interaction of myelin basic protein with actin in the presence of dodecylphosphocholine micelles. Biochemistry\| PubMed ID: 20593886	2010
Solid-state NMR spectroscopy of membrane-associated myelin basic protein--conformation and dynamics of an immunodominant epitope. Biophysical journal\| PubMed ID: 20713009	2010
Secondary structure and solvent accessibility of a calmodulin-binding C-terminal segment of membrane-associated myelin basic protein. Biochemistry\| PubMed ID: 20831157	2010
Interactions of intrinsically disordered Thellungiella salsuginea dehydrins TsDHN-1 and TsDHN-2 with membranesÂ - synergistic effects of lipid composition and temperature on secondary struct... Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 20921991	2010
Zinc induces disorder-to-order transitions in free and membrane-associated Thellungiella salsuginea dehydrins TsDHN-1 and TsDHN-2: a solution CD and solid-state ATR-FTIR study. Amino acids\| PubMed ID: 20924623	2011
Copper uptake induces self-assembly of 18.5 kDa myelin basic protein (MBP). Biophysical journal\| PubMed ID: 21044600	2010
Conformational choreography of a molecular switch region in myelin basic protein--molecular dynamics shows induced folding and secondary structure type conversion upon threonyl phosphorylati... Biochimica et biophysica acta\| PubMed ID: 21130728	2011
Myelin basic protein binds microtubules to a membrane surface and to actin filaments in vitro: effect of phosphorylation and deimination. Biochimica et biophysica acta\| PubMed ID: 21185260	2011
Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms. Journal of neuroscience research\| PubMed ID: 21234892	2011
Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms. Journal of neuroscience research\| PubMed ID: 21312222	2011
Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and pr... Journal of neuroscience research\| PubMed ID: 21887699	2012
Structured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interaction. Biophysical journal\| PubMed ID: 21889463	2011
Phosphorylation of Thellungiella salsuginea dehydrins TsDHN-1 and TsDHN-2 facilitates cation-induced conformational changes and actin assembly. Biochemistry\| PubMed ID: 21970344	2011
Classic 18.5- and 21.5-kDa Myelin Basic Protein Isoforms Associate with Cytoskeletal and SH3-Domain Proteins in the Immortalized N19-Oligodendroglial Cell Line Stimulated by Phorbol Ester an... Neurochemical research\| PubMed ID: 22249765	2012