Bruce L. Levine

Center for Cellular Immunotherapies, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 19	2021
Publication title	2026

Other Publications

Article	Year
Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nature medicine\| PubMed ID: 11786906	2002
TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12684428	2003
Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation. Blood\| PubMed ID: 12763934	2003
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood\| PubMed ID: 16189271	2006
Gene transfer in humans using a conditionally replicating lentiviral vector. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17090675	2006
Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer research\| PubMed ID: 17293384	2007
CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood\| PubMed ID: 17311991	2007
Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 17889349	2007
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18227839	2008
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. Journal of virology\| PubMed ID: 18337568	2008
T lymphocyte engineering ex vivo for cancer and infectious disease. Expert opinion on biological therapy\| PubMed ID: 18352851	2008
A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology\| PubMed ID: 18649912	2008
CD28 costimulation is essential for human T regulatory expansion and function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18684977	2008
Adoptive immunotherapy: good habits instilled at youth have long-term benefits. Immunologic research\| PubMed ID: 18949448	2008
Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19259065	2009
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19509133	2009
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Human gene therapy\| PubMed ID: 19719389	2010
Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood\| PubMed ID: 19724059	2009
Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program. Cytotherapy\| PubMed ID: 19903104	2009
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD. Autophagy\| PubMed ID: 20404486	2010
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood\| PubMed ID: 20570856	2010
Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomiz... Blood\| PubMed ID: 20864577	2011
Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer research\| PubMed ID: 20926399	2010
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood\| PubMed ID: 20952687	2011
Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood\| PubMed ID: 21030558	2011
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Science translational medicine\| PubMed ID: 21593401	2011
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes. Journal of translational medicine\| PubMed ID: 21827675	2011
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. The New England journal of medicine\| PubMed ID: 21830940	2011
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science translational medicine\| PubMed ID: 21832238	2011
Phase I trial of adoptive cell transfer with mixed-profile type-I/type-II allogeneic T cells for metastatic breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21948234	2011
Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission. Cancer immunology, immunotherapy : CII\| PubMed ID: 22021066	2012
Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate. Journal of translational medicine\| PubMed ID: 22082029	2011
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Science translational medicine\| PubMed ID: 22133721	2011
Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation. Blood\| PubMed ID: 22289893	2012
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Science translational medicine\| PubMed ID: 22553251	2012
Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23092876	2012
Convergence of gene and cell therapy. Regenerative medicine\| PubMed ID: 23210811	2012
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV. Blood\| PubMed ID: 23264589	2013
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Human gene therapy\| PubMed ID: 23360514	2013
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation. Blood\| PubMed ID: 23426943	2013
Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer. Oncoimmunology\| PubMed ID: 23482679	2013
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. The New England journal of medicine\| PubMed ID: 23527958	2013
Innovation and opportunity for chimeric antigen receptor targeted T cells. Cytotherapy\| PubMed ID: 23562306	2013
Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 23635453	2013
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood\| PubMed ID: 23770775	2013
A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23838316	2013
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Science translational medicine\| PubMed ID: 23926201	2013
Adoptive immunotherapy for cancer or viruses. Annual review of immunology\| PubMed ID: 24423116	2014
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer immunology research\| PubMed ID: 24432303	2013
Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24520093	2014
Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer immunology research\| PubMed ID: 24579088	2014
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. The New England journal of medicine\| PubMed ID: 24597865	2014
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer immunology research\| PubMed ID: 24777247	2013
Engineered T cells for cancer therapy. Cancer immunology, immunotherapy : CII\| PubMed ID: 24943274	2014
Chimeric antigen receptor T cells for sustained remissions in leukemia. The New England journal of medicine\| PubMed ID: 25317870	2014
The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25712684	2015
High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26071480	2015
NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma. Nature medicine\| PubMed ID: 26193344	2015
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science translational medicine\| PubMed ID: 26333935	2015
Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma. The New England journal of medicine\| PubMed ID: 26352815	2015
T cell engineering as therapy for cancer and HIV: our synthetic future. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 26416683	2015
Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect. Blood\| PubMed ID: 26563133	2016
Phase I study of multi-gene cell therapy in patients with peripheral artery disease. Vascular medicine (London, England)\| PubMed ID: 26584888	2016
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Blood\| PubMed ID: 26813675	2016
Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma. Annals of translational medicine\| PubMed ID: 26855949	2016
Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment. American journal of hematology\| PubMed ID: 26858124	2016
Chimeric Antigen Receptor T-Cell Therapy for the Community Oncologist. The oncologist\| PubMed ID: 27009942	2016
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia. Cancer discovery\| PubMed ID: 27076371	2016
Novel gene and cellular therapy approaches for treating HIV. Discovery medicine\| PubMed ID: 27232514	2016
miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency. Blood\| PubMed ID: 27485827	2016
Engineered T cells: the promise and challenges of cancer immunotherapy. Nature reviews. Cancer\| PubMed ID: 27550819	2016
Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials. Cytotherapy\| PubMed ID: 27887864	2017
PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR. Blood\| PubMed ID: 28031179	2017
Showcasing Clinical Development and Production of Cellular Therapies. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28341560	2017
Global Manufacturing of CAR T Cell Therapy. Molecular therapy. Methods & clinical development\| PubMed ID: 28344995	2017
Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. Cytotherapy\| PubMed ID: 28506444	2017
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Science translational medicine\| PubMed ID: 28724573	2017
Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy. Current hematologic malignancy reports\| PubMed ID: 28762038	2017
Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Blood\| PubMed ID: 28935694	2017
Exploring synthetic immunity: From boutique to global. Human vaccines & immunotherapeutics\| PubMed ID: 28945504	2017
Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer immunology research\| PubMed ID: 29109077	2017
Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 29203150	2018
Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. The New England journal of medicine\| PubMed ID: 29226764	2017
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. The New England journal of medicine\| PubMed ID: 29385370	2018
Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology\| PubMed ID: 29567081	2018
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. Science translational medicine\| PubMed ID: 29643231	2018
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI insight\| PubMed ID: 29669947	2018
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature medicine\| PubMed ID: 29713085	2018
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature\| PubMed ID: 29849141	2018
Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma. Blood\| PubMed ID: 29925499	2018
Reducing Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer immunology research\| PubMed ID: 30030295	2018
Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30190371	2018
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature medicine\| PubMed ID: 30275568	2018
CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success. Frontiers in immunology\| PubMed ID: 30559740	2018
Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods. Cytotherapy\| PubMed ID: 30770285	2019
Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells. CPT: pharmacometrics & systems pharmacology\| PubMed ID: 30848084	2019
B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. The Journal of clinical investigation\| PubMed ID: 30896447	2019
Powered and controlled T-cell production. Nature biomedical engineering\| PubMed ID: 31015722	2018
Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 31420241	2019
A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies. Cytotherapy\| PubMed ID: 31445816	2019
CAR T cell viability release testing and clinical outcomes: is there a lower limit? Blood\| PubMed ID: 31554634	2019
T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma. Blood advances\| PubMed ID: 31575532	2019
Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31707678	2020
Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 31815579	2020
CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration. The Journal of clinical investigation\| PubMed ID: 31845905	2020
CAR T-cell product performance in haematological malignancies before and after marketing authorisation. The Lancet. Oncology\| PubMed ID: 32007196	2020
The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19. Cytotherapy\| PubMed ID: 32014447	2020
CRISPR-engineered T cells in patients with refractory cancer. Science (New York, N.Y.)\| PubMed ID: 32029687	2020
Accelerating the development of innovative cellular therapy products for the treatment of cancer. Cytotherapy\| PubMed ID: 32199724	2020
Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 32298202	2020
International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: consi... Cytotherapy\| PubMed ID: 32425691	2020
Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies. Cytotherapy\| PubMed ID: 32565132	2020
Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 32730744	2020
Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood advances\| PubMed ID: 33095872	2020
Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 33186691	2021
The Coronavirus Pandemic: A Pitfall or a Fast Track for Validating Cell Therapy Products? Stem cells and development\| PubMed ID: 33307968	2021
Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature medicine\| PubMed ID: 33547459	2021
CCR5-edited CD4 T cells augment HIV-specific immunity to enable post rebound control of HIV replication. The Journal of clinical investigation\| PubMed ID: 33571163	2021
B-cell maturation antigen chimeric antigen receptor T-cell re-expansion in a patient with myeloma following salvage programmed cell death protein 1 inhibitor-based combination therapy. British journal of haematology\| PubMed ID: 33713436	2021
Perspective: assembly line immunotherapy. Nature\| PubMed ID: 23803946	2013
Advances in automated cell washing and concentration. Cytotherapy\| PubMed ID: 34052112	2021
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 34156874	2021
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. The Journal of clinical investigation\| PubMed ID: 34396987	2021
A randomized phase 2 trial of idiotype vaccination and adoptive autologous T-cell transfer in patients with multiple myeloma. Blood\| PubMed ID: 34521108	2022
The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 34526365	2021
Adoptive T-cell therapy for Hodgkin lymphoma. Blood advances\| PubMed ID: 34610100	2021
Decade-long leukaemia remissions with persistence of CD4 CAR T cells. Nature\| PubMed ID: 35110735	2022
The peril of the promise of speculative cell banking: Statement from the ISCT Committee on the Ethics of Cell and Gene Therapy. Cytotherapy\| PubMed ID: 35193823	2022
Anti-CD19 CAR T cells in combination with ibrutinib for the treatment of chronic lymphocytic leukemia. Blood advances\| PubMed ID: 35349631	2022
Patient access to and ethical considerations of the application of the European Union hospital exemption rule for advanced therapy medicinal products. Cytotherapy\| PubMed ID: 35545453	2022
Predicting T-cell quality during manufacturing through an artificial intelligence-based integrative multiomics analytical platform. Bioengineering & translational medicine\| PubMed ID: 35600660	2022
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 35705524	2022
Author Correction: Decade-long leukaemia remissions with persistence of CD4 CAR T cells. Nature\| PubMed ID: 36477542	2022
Paving the Road for Chimeric Antigen Receptor T Cells: American Society for Transplantation and Cellular Therapy 80/20 Task Force Consensus on Challenges and Solutions to Improving Efficienc... Transplantation and cellular therapy\| PubMed ID: 36709800	2023
Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors. Cell reports. Medicine\| PubMed ID: 37224816	2023
International Society for Cell & Gene Therapy Position Paper: Key considerations to support evidence-based cell and gene therapies and oppose marketing of unproven products. Cytotherapy\| PubMed ID: 37517865	2023
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging. Seminars in immunology\| PubMed ID: 37729825	2023
A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer. Nature cancer\| PubMed ID: 37735588	2023
A simulation-based comparison of centralized and point-of-care supply chain strategies for autologous cell therapy. Cytotherapy\| PubMed ID: 37747394	2023
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy. Nature medicine\| PubMed ID: 38195751	2024
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy. Nature medicine\| PubMed ID: 38266761	2024
Contract development and manufacturing organization selection: critical considerations that can make or break your cell and gene therapy development. Cytotherapy\| PubMed ID: 38530691	2024
Regulatory Considerations for Genome-Edited T-cell Therapies. Cancer immunology research\| PubMed ID: 39018097	2024
Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article. Human gene therapy\| PubMed ID: 39049734	2024
TET2 regulates early and late transitions in exhausted CD8 T cell differentiation and limits CAR T cell function. Science advances\| PubMed ID: 39536093	2024
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies. Nature medicine\| PubMed ID: 39833408	2025
Assessing the oncogenic risk: the long-term safety of autologous chimeric antigen receptor T cells. Lancet (London, England)\| PubMed ID: 40023653	2025
International Society for Cell & Gene Therapy Expanded Access Working Group position paper: key considerations to support equitable and ethical expanded access to investigational cell- and g... Cytotherapy\| PubMed ID: 40029229	2025
Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure. The New England journal of medicine\| PubMed ID: 40334157	2025
Cellular gene therapy access in Africa: a multifactorial feasibility analysis for implementation. Cytotherapy\| PubMed ID: 40377510	2025
The next innovations in chimeric antigen receptor T cell immunotherapies for cancer. Cytotherapy\| PubMed ID: 40542808	2025
Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. Frontiers in immunology\| PubMed ID: 40918142	2025
CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy. Nature biomedical engineering\| PubMed ID: 41120570	2025
Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations. Journal for immunotherapy of cancer\| PubMed ID: 41513407	2026
Clinical Trial Results Provide the Rationale to Protect Dual HIV-specific T Cells with a Signaling-Defective HIV Fusion Inhibitor. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 41520175	2026
Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 41566776	2026