Patrick Ruther

Department of Microsystems Engineering (IMTEK), University of Freiburg

Research Area

Biography

Patrick Ruther received the Diploma degree in physics and the Ph.D. degree in mechanical engineering in 1993 and 1996, respectively. From 1996 to 1998, he held a post-doctoral position at the Research Center Karlsruhe, Germany, where he was developing LIGA-based microoptical components. Since 1998, he has been a Senior Scientist at the Department of Microsystems Engineering (IMTEK), University of Freiburg. His focus is on the design, fabrication, and characterization of CMOScompatible MEMS devices, including microoptical functionality for biomedical applications, such as neuroscience and optogenetics. He coordinated the EU project NeuroSeeker targeting the next generation

of neural probes comprising electronic and optical functionality. He is a Co-Founder of the spin-off company ATLAS Neuroengineering, Belgium. He is a member of the Cluster of Excellence BrainLinks-BrainTools at the University of Freiburg.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2021

Other Publications

Article	Year
Comparative study on the insertion behavior of cerebral microprobes. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 18003057	2007
Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19568221	2009
Brain-computer interfaces: an overview of the hardware to record neural signals from the cortex. Progress in brain research\| PubMed ID: 19660664	2009
Characterization of parylene C as an encapsulation material for implanted neural prostheses. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 20119944	2010
Control and data acquisition software for high-density CMOS-based microprobe arrays implementing electronic depth control. Biomedizinische Technik. Biomedical engineering\| PubMed ID: 20441537	2010
A wireless multi-channel recording system for freely behaving mice and rats. PloS one\| PubMed ID: 21765934	2011
Compact wireless neural recording system for small animals using silicon-based probe arrays. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 22254797	2011
Investigation of a new electrode array technology for a central auditory prosthesis. PloS one\| PubMed ID: 24312638	2013
Oscillatory activity in the medial prefrontal cortex and nucleus accumbens correlates with impulsivity and reward outcome. PloS one\| PubMed ID: 25333512	2014
New approaches for CMOS-based devices for large-scale neural recording. Current opinion in neurobiology\| PubMed ID: 25463562	2015
Large-scale recording of thalamocortical circuits: in vivo electrophysiology with the two-dimensional electronic depth control silicon probe. Journal of neurophysiology\| PubMed ID: 27535370	2016
Extending the Cortical Grasping Network: Pre-supplementary Motor Neuron Activity During Vision and Grasping of Objects. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 27733538	2016
Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies. Biomedical microdevices\| PubMed ID: 28560702	2017
A silicon-based neural probe with densely-packed low-impedance titanium nitride microelectrodes for ultrahigh-resolution in vivo recordings. Biosensors & bioelectronics\| PubMed ID: 29414094	2018
Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces. Biomedizinische Technik. Biomedical engineering\| PubMed ID: 29478038	2018
Fine-scale mapping of cortical laminar activity during sleep slow oscillations using high-density linear silicon probes. Journal of neuroscience methods\| PubMed ID: 30144495	2019
High-Density μLED-Based Optical Cochlear Implant With Improved Thermomechanical Behavior. Frontiers in neuroscience\| PubMed ID: 30327585	2018
Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex. Frontiers in neuroscience\| PubMed ID: 30416424	2018
Development, Modeling, Fabrication, and Characterization of a Magnetic, Micro-Spring-Suspended System for the Safe Electrical Interconnection of Neural Implants. Micromachines\| PubMed ID: 30424357	2018
Microfluidic chip to interface porous microneedles for ISF collection. Biomedical microdevices\| PubMed ID: 30847695	2019
Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes. Frontiers in neuroscience\| PubMed ID: 31164800	2019
Towards the clinical translation of optogenetic skeletal muscle stimulation. Pflugers Archiv : European journal of physiology\| PubMed ID: 32415463	2020
μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve. EMBO molecular medicine\| PubMed ID: 32596983	2020
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents. Science translational medicine\| PubMed ID: 32718992	2020
Histological assessment of a chronically implanted cylindrically-shaped, polymer-based neural probe in the monkey. Journal of neural engineering\| PubMed ID: 33461177	2021
Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings. Scientific reports\| PubMed ID: 33479289	2021