Wolfram Goessling

Harvard Medical School

Affiliated withHarvard Medical School Brigham and Women’s Hospital Massachusetts General Hospital

Research Area

Biography

Wolfram Goessling has not added Biography.
If you are Wolfram Goessling and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2021

Other Publications

Article	Year
Merkel cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 11786590	2002
Increased liver chemistry in an asymptomatic patient. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 16234021	2005
Position Is Destiny: Metabolism and Cell Identity. Cell metabolism\| PubMed ID: 31067445	2019
New waves of discovery: modeling cancer in zebrafish. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17557959	2007
Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nature methods\| PubMed ID: 17572681	2007
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature\| PubMed ID: 17581586	2007
Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell stem cell\| PubMed ID: 18371439	2008
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental biology\| PubMed ID: 18585699	2008
Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology\| PubMed ID: 19010326	2008
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell\| PubMed ID: 19303855	2009
Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Molecular and cellular biology\| PubMed ID: 19380487	2009
Hematopoietic stem cell development is dependent on blood flow. Cell\| PubMed ID: 19450519	2009
PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 20200425	2010
Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. Cell stem cell\| PubMed ID: 20207217	2010
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (New York, N.Y.)\| PubMed ID: 20339075	2010
Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell stem cell\| PubMed ID: 21474107	2011
Endoderm specification, liver development, and regeneration. Methods in cell biology\| PubMed ID: 21550446	2011
Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting. American journal of human genetics\| PubMed ID: 21703590	2011
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS genetics\| PubMed ID: 21931561	2011
Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis. Methods in cell biology\| PubMed ID: 21951528	2011
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature genetics\| PubMed ID: 22001757	2011
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS genetics\| PubMed ID: 22479191	2012
Mutation mapping and identification by whole-genome sequencing. Genome research\| PubMed ID: 22555591	2012
SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. The Journal of experimental medicine\| PubMed ID: 22711876	2012
Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Developmental biology\| PubMed ID: 22982668	2012
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell\| PubMed ID: 23245941	2012
Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood\| PubMed ID: 23341543	2013
Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology\| PubMed ID: 23728495	2013
Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Disease models & mechanisms\| PubMed ID: 23813869	2013
Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge, England)\| PubMed ID: 24130329	2013
S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell reports\| PubMed ID: 24388745	2014
Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Developmental cell\| PubMed ID: 24530296	2014
Regenerative biology: Take the brakes off for liver repair. Nature\| PubMed ID: 24553235	2014
Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental cell\| PubMed ID: 24871948	2014
Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Disease models & mechanisms\| PubMed ID: 24973747	2014
Genome-wide association study of kidney function decline in individuals of European descent. Kidney international\| PubMed ID: 25493955	2015
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Nature communications\| PubMed ID: 25599650	2015
The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration. Current opinion in genetics & development\| PubMed ID: 25863341	2015
Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Stem cells (Dayton, Ohio)\| PubMed ID: 25931248	2015
Zebrafish: an important tool for liver disease research. Gastroenterology\| PubMed ID: 26319012	2015
Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem cell reports\| PubMed ID: 26365513	2015
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nature cell biology\| PubMed ID: 26389662	2015
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. eLife\| PubMed ID: 26436293	2015
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature communications\| PubMed ID: 26831199	2016
Cannabinoid receptor signaling regulates liver development and metabolism. Development (Cambridge, England)\| PubMed ID: 26884397	2016
Hypoxia as a therapy for mitochondrial disease. Science (New York, N.Y.)\| PubMed ID: 26917594	2016
EnaBILEing Growth in the Fetal Liver. Cell stem cell\| PubMed ID: 27058931	2016
Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer. Advances in experimental medicine and biology\| PubMed ID: 27165363	2016
Mitochondrial dysfunction remodels one-carbon metabolism in human cells. eLife\| PubMed ID: 27307216	2016
Nature and nurture: Environmental toxins and biliary atresia. Hepatology (Baltimore, Md.)\| PubMed ID: 27349921	2016
The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell stem cell\| PubMed ID: 27424782	2016
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature cell biology\| PubMed ID: 27428308	2016
Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Developmental biology\| PubMed ID: 27474396	2016
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27588899	2016
Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell reports\| PubMed ID: 27705794	2016
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nature genetics\| PubMed ID: 27918534	2017
and Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. Journal of the American Society of Nephrology : JASN\| PubMed ID: 27920155	2017
Haematopoietic stem cells show their true colours. Nature cell biology\| PubMed ID: 28008181	2016
WNTing no RASt for hepatocellular carcinoma. Hepatology (Baltimore, Md.)\| PubMed ID: 28295459	2017
The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Developmental biology\| PubMed ID: 28579318	2017
An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ genomic medicine\| PubMed ID: 30131872	2018
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO journal\| PubMed ID: 30348863	2018
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocyte... Gastroenterology\| PubMed ID: 30641053	2019
There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 31108233	2019
Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development (Cambridge, England)\| PubMed ID: 31160420	2019
Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nature genetics\| PubMed ID: 31406347	2019
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Molecular biology of the cell\| PubMed ID: 31774722	2020
Macrophages in Zebrafish Models of Liver Diseases. Frontiers in immunology\| PubMed ID: 31867007	2019
A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer. Investigational new drugs\| PubMed ID: 31898183	2020
YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental cell\| PubMed ID: 32032546	2020
Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development. Hepatology (Baltimore, Md.)\| PubMed ID: 32060934	2020
Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research\| PubMed ID: 32064511	2020
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. The Journal of clinical investigation\| PubMed ID: 32202514	2020
Hepatobiliary Differentiation: Principles from Embryonic Liver Development. Seminars in liver disease\| PubMed ID: 32526786	2020
Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity. iScience\| PubMed ID: 32712466	2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental cell\| PubMed ID: 32810442	2020
Learning During and From a Crisis: The Student-Led Development of a COVID-19 Curriculum. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 32941252	2021
The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity. Journal of cell science\| PubMed ID: 32973110	2020
Functional compensation precedes recovery of tissue mass following acute liver injury. Nature communications\| PubMed ID: 33214549	2020
Quantitative intravital imaging in zebrafish reveals dynamics of physiological-stress-induced mitophagy. Journal of cell science\| PubMed ID: 33536245	2021