Wim J. H. Hagen

Structural and Computational Biology Unit, European Molecular Biology Laboratory

Affiliated withEuropean Molecular Biology Laboratory

Research Area

Biography

Weapon systems engineer in the Royal Netherlands Navy (10 years), various roles (production, customer service, R&D, application support & management) at FEI Company (currently Thermo Fisher Scientific) in The Netherlands and the United States of America (ten years), responsible for cryo-EM operations at EMBL Heidelberg Germany since 2011.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2021

Other Publications

Article	Year
Determination of protein structure at 8.5Å resolution using cryo-electron tomography and sub-tomogram averaging. Journal of structural biology\| PubMed ID: 24184468	2013
SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion. EMBO reports\| PubMed ID: 24493260	2014
Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24843179	2014
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution. Nature\| PubMed ID: 25363765	2015
Seeing tobacco mosaic virus through direct electron detectors. Journal of structural biology\| PubMed ID: 25528571	2015
An organized co-assembly of clathrin adaptors is essential for endocytosis. Developmental cell\| PubMed ID: 25898165	2015
The selective autophagy receptor p62 forms a flexible filamentous helical scaffold. Cell reports\| PubMed ID: 25921531	2015
The Structure of Immature Virus-Like Rous Sarcoma Virus Gag Particles Reveals a Structural Role for the p10 Domain in Assembly. Journal of virology\| PubMed ID: 26223638	2015
Molecular structures of unbound and transcribing RNA polymerase III. Nature\| PubMed ID: 26605533	2015
Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Science (New York, N.Y.)\| PubMed ID: 27081072	2016
Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging. Journal of structural biology\| PubMed ID: 27313000	2017
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Science (New York, N.Y.)\| PubMed ID: 27417497	2016
Molecular Structures of Transcribing RNA Polymerase I. Molecular cell\| PubMed ID: 27867008	2016
The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science (New York, N.Y.)\| PubMed ID: 27980210	2016
Structure of the hexagonal surface layer on Caulobacter crescentus cells. Nature microbiology\| PubMed ID: 28418382	2017
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. eLife\| PubMed ID: 28621666	2017
Molecular mechanism of promoter opening by RNA polymerase III. Nature\| PubMed ID: 29345638	2018
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake. Nature communications\| PubMed ID: 31974402	2020
Benchmarking tomographic acquisition schemes for high-resolution structural biology. Nature communications\| PubMed ID: 32054835	2020
Structural basis for RNA polymerase III transcription repression by Maf1. Nature structural & molecular biology\| PubMed ID: 32066962	2020
TEM bright field imaging of thick specimens: nodes in Thon ring patterns. Ultramicroscopy\| PubMed ID: 32559707	2020
In-cell architecture of an actively transcribing-translating expressome. Science (New York, N.Y.)\| PubMed ID: 32732422	2020
Combining high throughput and high quality for cryo-electron microscopy data collection. Acta crystallographica. Section D, Structural biology\| PubMed ID: 32744254	2020
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science (New York, N.Y.)\| PubMed ID: 32817270	2020
Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32855298	2020
Defocus-dependent Thon-ring fading. Ultramicroscopy\| PubMed ID: 33524638	2021