Thorsten Hoppe

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne

Affiliated withUniversity of Cologne

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2021

Other Publications

Article	Year
Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO reports\| PubMed ID: 19079132	2009
Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 biology reports\| PubMed ID: 21151840	2010
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans. Genetics\| PubMed ID: 21288877	2011
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Molecular cell\| PubMed ID: 21981920	2011
Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22350911	2012
Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome. American journal of human genetics\| PubMed ID: 23200864	2012
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell\| PubMed ID: 23332754	2013
A novel interaction between aging and ER overload in a protein conformational dementia. Genetics\| PubMed ID: 23335331	2013
Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP. Biochimica et biophysica acta\| PubMed ID: 23583830	2014
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature\| PubMed ID: 23975097	2013
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature chemical biology\| PubMed ID: 24077178	2013
Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell\| PubMed ID: 24630720	2014
Ubiquitin sets the timer: impacts on aging and longevity. Nature structural & molecular biology\| PubMed ID: 24699075	2014
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell metabolism\| PubMed ID: 24703696	2014
Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24843123	2014
Reversible 26S proteasome disassembly upon mitochondrial stress. Cell reports\| PubMed ID: 24857655	2014
Limited proteolysis: DisRUPting proteasomal inhibition. Current biology : CB\| PubMed ID: 25093561	2014
The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Nucleic acids research\| PubMed ID: 25183520	2014
MicroRNAs meet calcium: joint venture in ER proteostasis. Science signaling\| PubMed ID: 25372053	2014
Regulation of the DNA damage response by ubiquitin conjugation. Frontiers in genetics\| PubMed ID: 25806049	2015
Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans. Frontiers in molecular biosciences\| PubMed ID: 25988162	2014
Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Current opinion in cell biology\| PubMed ID: 26343990	2015
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nature communications\| PubMed ID: 26842564	2016
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Frontiers in genetics\| PubMed ID: 27200082	2016
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. American journal of physiology. Cell physiology\| PubMed ID: 27225656	2016
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nature structural & molecular biology\| PubMed ID: 27669035	2016
Stefan Jentsch (1955-2016)-Maestro of the ubiquitin family. The EMBO journal\| PubMed ID: 27974363	2017
The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell\| PubMed ID: 28431247	2017
Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS letters\| PubMed ID: 28699655	2017
Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). Journal of cell science\| PubMed ID: 28827405	2017
Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity. Worm\| PubMed ID: 28959501	2017
CHIPped balance of proteostasis and longevity. Oncotarget\| PubMed ID: 29228542	2017
Stressed Out: Mitohormesis Is Crossing Borders. Trends in endocrinology and metabolism: TEM\| PubMed ID: 29605660	2018
Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 29611634	2018
Ub and Down: Ubiquitin Exercise for the Elderly. Trends in cell biology\| PubMed ID: 29704981	2018
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nature communications\| PubMed ID: 30038412	2018
ERADicate Tumor Progression with Metformin. Molecular cell\| PubMed ID: 30118675	2018
Hepatic ERAD takes control of the organism. The EMBO journal\| PubMed ID: 30389670	2018
Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans. Methods in enzymology\| PubMed ID: 30910027	2019
Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling. Nature metabolism\| PubMed ID: 31535080	2019
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy. Aging cell\| PubMed ID: 31625269	2020
Latest advances in aging research and drug discovery. Aging\| PubMed ID: 31770722	2019
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Nature communications\| PubMed ID: 31827090	2019
Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nature communications\| PubMed ID: 32066719	2020
Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly. F1000Research\| PubMed ID: 32076548	2020
Mitochondrial Quality Control Governed by Ubiquitin. Frontiers in cell and developmental biology\| PubMed ID: 32391359	2020
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Communications biology\| PubMed ID: 32451438	2020
Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling. Nature metabolism\| PubMed ID: 32694680	2020
Organismal Protein Homeostasis Mechanisms. Genetics\| PubMed ID: 32759342	2020
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell death & disease\| PubMed ID: 32913203	2020
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. eLife\| PubMed ID: 33021200	2020
Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores. American journal of human genetics\| PubMed ID: 33217308	2020
The price of longevity. Aging\| PubMed ID: 33253121	2020
Build-UPS and break-downs: metabolism impacts on proteostasis and aging. Cell death and differentiation\| PubMed ID: 33398091	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy\| PubMed ID: 33634751	2021
Correction to: Build-UPS and break-downs: metabolism impacts on proteostasis and aging. Cell death and differentiation\| PubMed ID: 33976390	2021