Magdalena M. Szewczyk

Structural Genomics Consortium, University of Toronto

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2021

Other Publications

Article	Year
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English)\| PubMed ID: 25728001	2015
Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS medicinal chemistry letters\| PubMed ID: 25893041
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of medicinal chemistry\| PubMed ID: 26824386
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of medicinal chemistry\| PubMed ID: 27390919
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 27584694	2016
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature chemical biology\| PubMed ID: 28135237
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature communications\| PubMed ID: 29142305
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry\| PubMed ID: 29244490	2018
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget\| PubMed ID: 29719619
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS medicinal chemistry letters\| PubMed ID: 30034588
Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression. Experimental hematology\| PubMed ID: 30352278
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology\| PubMed ID: 31285596
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer cell\| PubMed ID: 31408619
Discovery of a chemical probe for PRDM9. Nature communications\| PubMed ID: 31848333
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of medicinal chemistry\| PubMed ID: 32367723
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32409666
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32457299
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry\| PubMed ID: 33522809	2021
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 33591753	2021
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry\| PubMed ID: 33980013	2021
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid. ChemMedChem\| PubMed ID: 34164919	2021

Article	Year
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English)\| PubMed ID: 25728001	2015
Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS medicinal chemistry letters\| PubMed ID: 25893041
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of medicinal chemistry\| PubMed ID: 26824386
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of medicinal chemistry\| PubMed ID: 27390919
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 27584694	2016
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature chemical biology\| PubMed ID: 28135237
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature communications\| PubMed ID: 29142305
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry\| PubMed ID: 29244490	2018
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget\| PubMed ID: 29719619
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS medicinal chemistry letters\| PubMed ID: 30034588
Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression. Experimental hematology\| PubMed ID: 30352278
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology\| PubMed ID: 31285596
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer cell\| PubMed ID: 31408619
Discovery of a chemical probe for PRDM9. Nature communications\| PubMed ID: 31848333
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of medicinal chemistry\| PubMed ID: 32367723
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32409666
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32457299
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry\| PubMed ID: 33522809	2021
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 33591753	2021
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry\| PubMed ID: 33980013	2021
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid. ChemMedChem\| PubMed ID: 34164919	2021