Dalia Barsyte-Lovejoy

Structural Genomics Consortium, University of Toronto

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2021
Publication title Cited by 1	2023

Other Publications

Article	Year
Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Current biology : CB\| PubMed ID: 12747840	2003
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene\| PubMed ID: 15021909
Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss). General and comparative endocrinology\| PubMed ID: 15158132
Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Nucleic acids research\| PubMed ID: 15226411
Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Brain research. Molecular brain research\| PubMed ID: 15710242
Cancer therapeutics: targeting the dark side of Myc. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16243519
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer research\| PubMed ID: 16707459
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17600088
Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypot... Brain research\| PubMed ID: 17900539
CUL7 is a novel antiapoptotic oncogene. Cancer research\| PubMed ID: 17942889	2007
Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies. Annals of the New York Academy of Sciences\| PubMed ID: 19456342
Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family. General and comparative endocrinology\| PubMed ID: 19646444
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology\| PubMed ID: 21743462	2011
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of medicinal chemistry\| PubMed ID: 21780790	2011
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell\| PubMed ID: 22464331
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. The Biochemical journal\| PubMed ID: 22989411	2013
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature structural & molecular biology\| PubMed ID: 23022729	2012
C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Molecular and cellular neurosciences\| PubMed ID: 23026563
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature communications\| PubMed ID: 23250418	2012
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature chemical biology\| PubMed ID: 23292653	2013
Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction. Progress in biophysics and molecular biology\| PubMed ID: 23500148
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS chemical biology\| PubMed ID: 23614352	2013
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of medicinal chemistry\| PubMed ID: 24102134	2013
A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a. ChemMedChem\| PubMed ID: 24443078
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25136132	2014
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English)\| PubMed ID: 25728001	2015
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. The Journal of biological chemistry\| PubMed ID: 25825497	2015
Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS medicinal chemistry letters\| PubMed ID: 25893041
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature chemical biology\| PubMed ID: 26167872
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature\| PubMed ID: 26331536
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS chemical biology\| PubMed ID: 26598975	2016
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer cell\| PubMed ID: 26626085
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of medicinal chemistry\| PubMed ID: 26824386
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. Journal of medicinal chemistry\| PubMed ID: 27075367
An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates. Journal of proteome research\| PubMed ID: 27163177
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of medicinal chemistry\| PubMed ID: 27390919
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 27584694	2016
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer cell\| PubMed ID: 27960086
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nature chemical biology\| PubMed ID: 28114273
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature chemical biology\| PubMed ID: 28135237
Targeting human SET1/MLL family of proteins. Protein science : a publication of the Protein Society\| PubMed ID: 28160335
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature communications\| PubMed ID: 29142305
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry\| PubMed ID: 29244490	2018
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget\| PubMed ID: 29719619
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. The Journal of cell biology\| PubMed ID: 29921600
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS medicinal chemistry letters\| PubMed ID: 30034588
Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression. Experimental hematology\| PubMed ID: 30352278
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic acids research\| PubMed ID: 30462309
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nature communications\| PubMed ID: 30604761
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Frontiers in endocrinology\| PubMed ID: 30774623
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nature communications\| PubMed ID: 30926792
Targeting protein methylation: from chemical tools to precision medicines. Cellular and molecular life sciences : CMLS\| PubMed ID: 31104094
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of medicinal chemistry\| PubMed ID: 31260300
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology\| PubMed ID: 31285596
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer cell\| PubMed ID: 31287992
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer cell\| PubMed ID: 31408619
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. Journal of medicinal chemistry\| PubMed ID: 31415173
SETD7 at the heart of chromatin factor interplay. Stem cell investigation\| PubMed ID: 31559307
Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers. Frontiers in endocrinology\| PubMed ID: 31781029
Discovery of a chemical probe for PRDM9. Nature communications\| PubMed ID: 31848333
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment. eLife\| PubMed ID: 32297856
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of medicinal chemistry\| PubMed ID: 32367723
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32409666
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32457299
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry\| PubMed ID: 33522809	2021
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature communications\| PubMed ID: 33579912	2021
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 33591753	2021
Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature reviews. Drug discovery\| PubMed ID: 33742187	2021
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry\| PubMed ID: 33980013	2021
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. SLAS discovery : advancing life sciences R & D\| PubMed ID: 34154424	2021
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid. ChemMedChem\| PubMed ID: 34164919	2021
Structure and Function of Protein Arginine Methyltransferase PRMT7. Life (Basel, Switzerland)\| PubMed ID: 34440512	2021
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology\| PubMed ID: 34782742	2022
PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Redox biology\| PubMed ID: 35305370	2022
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade. Cell reports\| PubMed ID: 35354055	2022
Validating Small Molecule Chemical Probes for Biological Discovery. Annual review of biochemistry\| PubMed ID: 35363509	2022
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nature chemical biology\| PubMed ID: 35578032	2022
Chemical biology and pharmacology of histone lysine methylation inhibitors. Biochimica et biophysica acta. Gene regulatory mechanisms\| PubMed ID: 35753676	2022
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro. Biochimica et biophysica acta. Gene regulatory mechanisms\| PubMed ID: 35907431	2022
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. ACS chemical biology\| PubMed ID: 36084291	2022
Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, : A potential antagonist of corticotropin-... Biochemistry and biophysics reports\| PubMed ID: 36467544	2022
Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1. Frontiers in physiology\| PubMed ID: 36523555	2022

Article	Year
Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Current biology : CB\| PubMed ID: 12747840	2003
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene\| PubMed ID: 15021909
Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss). General and comparative endocrinology\| PubMed ID: 15158132
Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Nucleic acids research\| PubMed ID: 15226411
Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Brain research. Molecular brain research\| PubMed ID: 15710242
Cancer therapeutics: targeting the dark side of Myc. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16243519
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer research\| PubMed ID: 16707459
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17600088
Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypot... Brain research\| PubMed ID: 17900539
CUL7 is a novel antiapoptotic oncogene. Cancer research\| PubMed ID: 17942889	2007
Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies. Annals of the New York Academy of Sciences\| PubMed ID: 19456342
Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family. General and comparative endocrinology\| PubMed ID: 19646444
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology\| PubMed ID: 21743462	2011
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of medicinal chemistry\| PubMed ID: 21780790	2011
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell\| PubMed ID: 22464331
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. The Biochemical journal\| PubMed ID: 22989411	2013
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature structural & molecular biology\| PubMed ID: 23022729	2012
C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Molecular and cellular neurosciences\| PubMed ID: 23026563
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature communications\| PubMed ID: 23250418	2012
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature chemical biology\| PubMed ID: 23292653	2013
Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction. Progress in biophysics and molecular biology\| PubMed ID: 23500148
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS chemical biology\| PubMed ID: 23614352	2013
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of medicinal chemistry\| PubMed ID: 24102134	2013
A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a. ChemMedChem\| PubMed ID: 24443078
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25136132	2014
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English)\| PubMed ID: 25728001	2015
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. The Journal of biological chemistry\| PubMed ID: 25825497	2015
Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS medicinal chemistry letters\| PubMed ID: 25893041
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature chemical biology\| PubMed ID: 26167872
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature\| PubMed ID: 26331536
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS chemical biology\| PubMed ID: 26598975	2016
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer cell\| PubMed ID: 26626085
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of medicinal chemistry\| PubMed ID: 26824386
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. Journal of medicinal chemistry\| PubMed ID: 27075367
An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates. Journal of proteome research\| PubMed ID: 27163177
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of medicinal chemistry\| PubMed ID: 27390919
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 27584694	2016
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer cell\| PubMed ID: 27960086
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nature chemical biology\| PubMed ID: 28114273
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature chemical biology\| PubMed ID: 28135237
Targeting human SET1/MLL family of proteins. Protein science : a publication of the Protein Society\| PubMed ID: 28160335
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature communications\| PubMed ID: 29142305
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry\| PubMed ID: 29244490	2018
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget\| PubMed ID: 29719619
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. The Journal of cell biology\| PubMed ID: 29921600
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS medicinal chemistry letters\| PubMed ID: 30034588
Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression. Experimental hematology\| PubMed ID: 30352278
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic acids research\| PubMed ID: 30462309
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nature communications\| PubMed ID: 30604761
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Frontiers in endocrinology\| PubMed ID: 30774623
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nature communications\| PubMed ID: 30926792
Targeting protein methylation: from chemical tools to precision medicines. Cellular and molecular life sciences : CMLS\| PubMed ID: 31104094
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of medicinal chemistry\| PubMed ID: 31260300
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology\| PubMed ID: 31285596
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer cell\| PubMed ID: 31287992
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer cell\| PubMed ID: 31408619
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. Journal of medicinal chemistry\| PubMed ID: 31415173
SETD7 at the heart of chromatin factor interplay. Stem cell investigation\| PubMed ID: 31559307
Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers. Frontiers in endocrinology\| PubMed ID: 31781029
Discovery of a chemical probe for PRDM9. Nature communications\| PubMed ID: 31848333
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment. eLife\| PubMed ID: 32297856
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of medicinal chemistry\| PubMed ID: 32367723
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32409666
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications\| PubMed ID: 32457299
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry\| PubMed ID: 33522809	2021
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature communications\| PubMed ID: 33579912	2021
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 33591753	2021
Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature reviews. Drug discovery\| PubMed ID: 33742187	2021
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry\| PubMed ID: 33980013	2021
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. SLAS discovery : advancing life sciences R & D\| PubMed ID: 34154424	2021
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid. ChemMedChem\| PubMed ID: 34164919	2021
Structure and Function of Protein Arginine Methyltransferase PRMT7. Life (Basel, Switzerland)\| PubMed ID: 34440512	2021
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology\| PubMed ID: 34782742	2022
PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Redox biology\| PubMed ID: 35305370	2022
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade. Cell reports\| PubMed ID: 35354055	2022
Validating Small Molecule Chemical Probes for Biological Discovery. Annual review of biochemistry\| PubMed ID: 35363509	2022
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nature chemical biology\| PubMed ID: 35578032	2022
Chemical biology and pharmacology of histone lysine methylation inhibitors. Biochimica et biophysica acta. Gene regulatory mechanisms\| PubMed ID: 35753676	2022
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro. Biochimica et biophysica acta. Gene regulatory mechanisms\| PubMed ID: 35907431	2022
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. ACS chemical biology\| PubMed ID: 36084291	2022
Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, : A potential antagonist of corticotropin-... Biochemistry and biophysics reports\| PubMed ID: 36467544	2022
Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1. Frontiers in physiology\| PubMed ID: 36523555	2022