Stephen Dewhurst

Department of Microbiology and Immunology, University of Rochester Medical Center

Affiliated withUniversity of Rochester Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 11	2012
Publication title Cited by 4	2016

Other Publications

Article	Year
Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of virology\| PubMed ID: 11991985	2002
Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? Journal of neurovirology\| PubMed ID: 12476354	2002
Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. Journal of molecular biology\| PubMed ID: 12595259	2003
Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque. The Journal of biological chemistry\| PubMed ID: 12740369	2003
Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine\| PubMed ID: 12744859	2003
A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells. European journal of biochemistry / FEBS\| PubMed ID: 12752448	2003
Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes. Journal of virology\| PubMed ID: 12805417	2003
Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame. Journal of virological methods\| PubMed ID: 12880930	2003
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14534250	2003
Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 15100244	2004
Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors. Journal of neuroscience methods\| PubMed ID: 15183265	2004
Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. Journal of neuroscience research\| PubMed ID: 15211592	2004
Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system. Herpes : the journal of the IHMF\| PubMed ID: 15319097	2004
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. The Journal of biological chemistry\| PubMed ID: 15452123	2004
Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). The Journal of pediatrics\| PubMed ID: 15480369	2004
Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. The Journal of pediatrics\| PubMed ID: 15480370	2004
False memories in children. Evidence for a shift from phonological to semantic associations. Psychological science\| PubMed ID: 15482451	2004
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. Brain research. Molecular brain research\| PubMed ID: 15548427	2004
Inhibition of HIV type 1 replication using lentiviral-mediated delivery of mutant tRNA(Lys3)A58U. AIDS research and human retroviruses\| PubMed ID: 15650425	2004
Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted in... Journal of virology\| PubMed ID: 15681415	2005
Valproic acid enhances gene expression from viral gene transfer vectors. Journal of virological methods\| PubMed ID: 15737413	2005
Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death. Neuropharmacology\| PubMed ID: 15755485	2005
HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15778398	2005
Intention to learn influences the word frequency effect in recall but not in recognition memory. Memory & cognition\| PubMed ID: 15900925	2004
Measuring the speed of the conscious components of recognition memory: remembering is faster than knowing. Consciousness and cognition\| PubMed ID: 16019226	2006
The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro. Journal of virology\| PubMed ID: 16140767	2005
HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. The journal of gene medicine\| PubMed ID: 16142830	2006
Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens. Vaccine\| PubMed ID: 16154247	2006
Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16162919	2005
A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda. Nucleic acids research\| PubMed ID: 16224099	2005
Selective interference with the use of visual images in the symbolic distance paradigm. Journal of experimental psychology. Learning, memory, and cognition\| PubMed ID: 16248750	2005
Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6. The Journal of infectious diseases\| PubMed ID: 16544246	2006
Distinctiveness, typicality, and recollective experience in face recognition: a principal components analysis. Psychonomic bulletin & review\| PubMed ID: 16615324	2005
Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16785569	2006
Amplicons as vaccine vectors. Current gene therapy\| PubMed ID: 16787189	2006
Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons. The European journal of neuroscience\| PubMed ID: 16817865	2006
Dissociating word frequency and age of acquisition: The Klein effect revived (and reversed). Journal of experimental psychology. Learning, memory, and cognition\| PubMed ID: 16822157	2006
Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine\| PubMed ID: 17145123	2007
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. Journal of molecular biology\| PubMed ID: 17157319	2007
Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. Journal of virology\| PubMed ID: 17182671	2007
Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo. Vaccine\| PubMed ID: 17293010	2007
Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human gene therapy\| PubMed ID: 17298238	2007
Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312171	2007
A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery. Nucleic acids research\| PubMed ID: 17392341	2007
Story contexts increase susceptibility to the DRM illusion in 5-year-olds. Developmental science\| PubMed ID: 17444977	2007
Reinstating effortful encoding operations at test enhances episodic remembering. Quarterly journal of experimental psychology (2006)\| PubMed ID: 17455065	2007
Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of virological methods\| PubMed ID: 17606303	2007
Divided attention at retrieval disrupts knowing but not remembering. Memory (Hove, England)\| PubMed ID: 17654280	2007
The effect of divided attention on false memory depends on how memory is tested. Memory & cognition\| PubMed ID: 17848024	2007
HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine\| PubMed ID: 17868958	2007
The effect of glucose administration on the recollection and familiarity components of recognition memory. Biological psychology\| PubMed ID: 17950982	2008
Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors. The journal of gene medicine\| PubMed ID: 17966114	2007
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 18040831	2007
Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18097031	2008
Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells. Virology\| PubMed ID: 18191979	2008
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology\| PubMed ID: 18237430	2008
The effects of divided attention at study and test on false recognition: a comparison of DRM and categorized lists. Memory & cognition\| PubMed ID: 18265611	2007
Dynamic visual noise interferes with storage in visual working memory. Experimental psychology\| PubMed ID: 18683625	2008
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subu... The Journal of general virology\| PubMed ID: 19008377	2008
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PloS one\| PubMed ID: 19009018	2008
False and veridical collaborative recognition. Memory (Hove, England)\| PubMed ID: 19058091	2009
Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells. Virology\| PubMed ID: 19064273	2009
Remembering the past and imagining the future: differences in event specificity of spontaneously generated thought. Memory (Hove, England)\| PubMed ID: 19235018	2009
Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment. Journal of neurovirology\| PubMed ID: 19306230	2009
Nef gene evolution from a single transmitted strain in acute SIV infection. Retrovirology\| PubMed ID: 19505314	2009
The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate. Biochemistry\| PubMed ID: 19817489	2009
Neuroprotective activities of CEP-1347 in models of neuroAIDS. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19966207	2010
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology\| PubMed ID: 20185156	2010
Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still... Journal of virology\| PubMed ID: 20335256	2010
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. PloS one\| PubMed ID: 20454455	2010
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20495069	2010
Can false memories prime problem solutions? Cognition\| PubMed ID: 20813356	2010
Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection. The Journal of biological chemistry\| PubMed ID: 20833717	2010
Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 20880503	2010
Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing research\| PubMed ID: 20971179	2010
Methamphetamine causes sustained depression in cerebral blood flow. Brain research\| PubMed ID: 21156163	2011
Investigating the encoding-retrieval match in recognition memory: effects of experimental design, specificity, and retention interval. Memory & cognition\| PubMed ID: 21156873	2010
Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env. Vaccine\| PubMed ID: 21310193	2011
The development of automatic and controlled inhibitory retrieval processes in true and false recall. Journal of experimental child psychology\| PubMed ID: 21320706	2011
Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides. Biophysical journal\| PubMed ID: 21354406	2011
A gender difference in the false recall of negative words: women DRM more than men. Cognition & emotion\| PubMed ID: 21432635	2012
Test-induced priming impairs source monitoring accuracy in the DRM procedure. Journal of experimental psychology. Learning, memory, and cognition\| PubMed ID: 21480753	2011
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. Journal of virology\| PubMed ID: 21561908	2011
Dazed and confused by HHV-6. Blood\| PubMed ID: 21566101	2011
Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS. Journal of neuroinflammation\| PubMed ID: 21569583	2011
Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors. Journal of virology\| PubMed ID: 21715506	2011
Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual ba... Vaccine\| PubMed ID: 21801777	2011
Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. The Journal of biological chemistry\| PubMed ID: 21816827	2011
What factors underlie associative and categorical memory illusions? The roles of backward associative strength and interitem connectivity. Journal of experimental psychology. Learning, memory, and cognition\| PubMed ID: 21875250	2011
Test-induced priming increases false recognition in older but not younger children. Journal of experimental child psychology\| PubMed ID: 21908005	2012
HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PloS one\| PubMed ID: 21912650	2011
Shared cognitive processes underlying past and future thinking: The impact of imagery and concurrent task demands on event specificity. Journal of experimental psychology. Learning, memory, and cognition\| PubMed ID: 21928933	2011
Advances in HIV microbicide development. Future medicinal chemistry\| PubMed ID: 22098355	2011
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PloS one\| PubMed ID: 22174876	2011
Oligovalent Amyloid-Binding Agents Reduce SEVI-Mediated Enhancement of HIV-1 Infection. Journal of the American Chemical Society\| PubMed ID: 22239120	2012
Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide. The Journal of biological chemistry\| PubMed ID: 22354963	2012
9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. PloS one\| PubMed ID: 22530008	2012
Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase. Journal of virology\| PubMed ID: 22811532	2012
Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of c... Journal of neuroinflammation\| PubMed ID: 23167821	2012
Anti-idiotypic monobodies derived from a fibronectin scaffold. Biochemistry\| PubMed ID: 23394681	2013
Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial... Antimicrobial agents and chemotherapy\| PubMed ID: 23507280	2013
Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23511246	2013
Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images. Pattern recognition\| PubMed ID: 23525856	2013
Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients. Journal of neurovirology\| PubMed ID: 23737347	2013
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23761895	2013
Fluorescence detection of cationic amyloid fibrils in human semen. Bioorganic & medicinal chemistry letters\| PubMed ID: 23910594	2013
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. Journal of medicinal chemistry\| PubMed ID: 24044867	2013
Classification of HHV-6A and HHV-6B as distinct viruses. Archives of virology\| PubMed ID: 24193951	2014
Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging and disease\| PubMed ID: 24307964	2013
Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies. Journal of virological methods\| PubMed ID: 24316333	2014
9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles. PloS one\| PubMed ID: 24386452	2013
MLK3 regulates fMLP-stimulated neutrophil motility. Molecular immunology\| PubMed ID: 24389043	2014
What factors underlie children's susceptibility to semantic and phonological false memories? investigating the roles of language skills and auditory short-term memory. Cognition\| PubMed ID: 24632322	2014
Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 24813724	2014
Theoretical model of critical issues in informed consent in HIV vaccine trials. AIDS care\| PubMed ID: 24865892	2014
Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development. Journal of virology\| PubMed ID: 24965472	2014
Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters. Antimicrobial agents and chemotherapy\| PubMed ID: 25224011	2014
Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model. PloS one\| PubMed ID: 25264786	2014
Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine. Journal of virology\| PubMed ID: 25552727	2015
Episodic elaboration: Investigating the structure of retrieved past events and imagined future events. Consciousness and cognition\| PubMed ID: 25555290	2015
Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles. ACS nano\| PubMed ID: 25619867	2015
Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25834052	2015
Eyewitness memory: The impact of a negative mood during encoding and/or retrieval upon recall of a non-emotive event. Memory (Hove, England)\| PubMed ID: 26273852	2015
A dysphoric's TALE: The relationship between the self-reported functions of autobiographical memory and symptoms of depression. Memory (Hove, England)\| PubMed ID: 26371517	2015
Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-based Antibacterial Ointments. Antimicrobial agents and chemotherapy\| PubMed ID: 26596945	2015
A single mutation at PB1 residue 319 dramatically increases the safety of PR8 LAIV in a murine model without compromising vaccine efficacy. Journal of virology\| PubMed ID: 26676793	2015