Oliver Schilling

Institute for Surgical Pathology, University of Freiburg

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2021

Other Publications

Article	Year
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance. Translational oncology\| PubMed ID: 30172883	2018
Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nature protocols\| PubMed ID: 21212787	2011
Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21604128	2011
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. The Journal of biological chemistry\| PubMed ID: 21646356	2011
Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Molecular & cellular proteomics : MCP\| PubMed ID: 21693781	2011
Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biological chemistry\| PubMed ID: 21846260	2011
Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21877277	2011
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. Journal of proteome research\| PubMed ID: 21967108	2011
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biological chemistry\| PubMed ID: 21972973	2011
NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22474388	2012
Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides. Proteomics\| PubMed ID: 22589179	2012
Glycocapture-based proteomics for secretome analysis. Proteomics\| PubMed ID: 23197367	2013
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. Molecular & cellular proteomics : MCP\| PubMed ID: 23233448	2012
Global remodelling of cellular microenvironment due to loss of collagen VII. Molecular systems biology\| PubMed ID: 23591773	2013
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cellular and molecular life sciences : CMLS\| PubMed ID: 23811845	2014
Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells. Molecular oncology\| PubMed ID: 24120346	2014
Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling. PloS one\| PubMed ID: 24505282	2014
Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer. Surgery\| PubMed ID: 24929761	2014
Automated peptide mapping and protein-topographical annotation of proteomics data. BMC bioinformatics\| PubMed ID: 24946880	2014
Carboxyterminal protein processing in health and disease: key actors and emerging technologies. Journal of proteome research\| PubMed ID: 25204196	2014
Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. mBio\| PubMed ID: 25293760	2014
Protein amino-terminal modifications and proteomic approaches for N-terminal profiling. Current opinion in chemical biology\| PubMed ID: 25461725	2015
The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro-oncology\| PubMed ID: 25825051	2015
Toward improved peptide feature detection in quantitative proteomics using stable isotope labeling. Proteomics. Clinical applications\| PubMed ID: 25931027	2015
Enrichment of protein N-termini by charge reversal of internal peptides. Proteomics\| PubMed ID: 26013158	2015
miR-200c dampens cancer cell migration via regulation of protein kinase A subunits. Oncotarget\| PubMed ID: 26203557	2015
The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia. Biochimica et biophysica acta\| PubMed ID: 26209915	2015
Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines. BMC genomics\| PubMed ID: 26220445	2015
Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations. Molecular oncology\| PubMed ID: 26304112	2016
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage... Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 26407638	2016
An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Cell reports\| PubMed ID: 26440886	2015
Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie\| PubMed ID: 26455267	2016
A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity. The Journal of biological chemistry\| PubMed ID: 26582203	2016
Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study. Medicine\| PubMed ID: 26817896	2016
Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses. BMC cancer\| PubMed ID: 26951071	2016
Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini. Molecular & cellular proteomics : MCP\| PubMed ID: 27087653	2016
Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations. Journal of proteome research\| PubMed ID: 27089454	2016
Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Molecular & cellular proteomics : MCP\| PubMed ID: 27122596	2016
The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Archives of biochemistry and biophysics\| PubMed ID: 27246477	2016
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels. Journal of translational medicine\| PubMed ID: 27246731	2016
Comprehensive Proteomic Analysis of Nitrogen-Starved Mycobacterium smegmatis Δpup Reveals the Impact of Pupylation on Nitrogen Stress Response. Journal of proteome research\| PubMed ID: 27378031	2016
Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1. Biochimica et biophysica acta\| PubMed ID: 27426920	2016
Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response. Journal of proteome research\| PubMed ID: 27432266	2016
Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data. Current protein & peptide science\| PubMed ID: 27455965	2017
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality. Biochimica et biophysica acta\| PubMed ID: 27526672	2016
OpenMS: a flexible open-source software platform for mass spectrometry data analysis. Nature methods\| PubMed ID: 27575624	2016
Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. Journal of Cancer\| PubMed ID: 27877217	2016
Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling. Cell reports\| PubMed ID: 27926865	2016
The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 28188928	2017
Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28299738	2017
System-Wide Profiling of Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissue Specimens for the Identification of Novel Substrates. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28315246	2017
Profiling of Protease Cleavage Sites by Proteome-Derived Peptide Libraries and Quantitative Proteomics. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28315252	2017
Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery\| PubMed ID: 28329269	2017
The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study. Journal of Cancer\| PubMed ID: 28367245	2017
Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 28475002	2017
Differential effect of TGFβ on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report. Cellular oncology (Dordrecht)\| PubMed ID: 28808957	2017
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication. Scientific reports\| PubMed ID: 29093542	2017
Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 29158163	2018
Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression. Journal of Cancer\| PubMed ID: 29187882	2017
Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease. Oncotarget\| PubMed ID: 29245961	2017
Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases. Neoplasia (New York, N.Y.)\| PubMed ID: 29248718	2018
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine\| PubMed ID: 29269042	2018
Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization. Clinical proteomics\| PubMed ID: 29527141	2018
The pleiotropic roles of ADAM9 in the biology of solid tumors. Cellular and molecular life sciences : CMLS\| PubMed ID: 29550974	2018
N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degenera... Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 29572155	2018
Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype. Scientific reports\| PubMed ID: 29593307	2018
Specificity profiling of human trypsin-isoenzymes. Biological chemistry\| PubMed ID: 29883318	2018
The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities. Biological chemistry\| PubMed ID: 29924726	2018
Nanoparticle decoration impacts airborne fungal pathobiology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29925597	2018
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Scientific reports\| PubMed ID: 30013126	2018
Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas. Clinical proteomics\| PubMed ID: 30087584	2018
Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics. Molecular & cellular proteomics : MCP\| PubMed ID: 30257879	2019
Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer\| PubMed ID: 30287916	2018
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics. Biomaterials\| PubMed ID: 30530244	2019
Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways. Cellular microbiology\| PubMed ID: 30551267	2019
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. Molecular oncology\| PubMed ID: 30556643	2019
Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol. Cell chemical biology\| PubMed ID: 31006617	2019
Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study wi... Theranostics\| PubMed ID: 31131055	2019
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome. Journal of cellular and molecular medicine\| PubMed ID: 31368174	2019
A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins. Mobile DNA\| PubMed ID: 31462935	2019
Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy. Artificial organs\| PubMed ID: 31494943	2020
Neuronal-specific microexon splicing of mRNA is directly regulated by SRRM4/nSR100. RNA biology\| PubMed ID: 31559909	2020
Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine. Metabolites\| PubMed ID: 31635306	2019
Accessible and reproducible mass spectrometry imaging data analysis in Galaxy. GigaScience\| PubMed ID: 31816088	2019
Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death. Cancer cell international\| PubMed ID: 32095117	2020
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. Cellular and molecular life sciences : CMLS\| PubMed ID: 32385587	2021
FOLFIRINOX Gemcitabine-based Therapy for Pancreatic Ductal Adenocarcinoma: Lessons from Patient-derived Cell Lines. Anticancer research\| PubMed ID: 32620605	2020
Deep multiple instance learning classifies subtissue locations in mass spectrometry images from tissue-level annotations. Bioinformatics (Oxford, England)\| PubMed ID: 32657378	2020
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nature communications\| PubMed ID: 32807776	2020
Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer. Molecular cancer research : MCR\| PubMed ID: 32873625	2020
Corrigendum to "Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics" [Biomaterials 192 (2019)... Biomaterials\| PubMed ID: 32932141	2020
Multimodal imaging for radiation therapy planning in patients with primary prostate cancer. Physics and imaging in radiation oncology\| PubMed ID: 33458410	2018
Discovery of a small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33509926	2021
SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. Journal of the American Society of Nephrology : JASN\| PubMed ID: 33514561	2021
Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage. International journal of molecular sciences\| PubMed ID: 33562184	2021
Role of Kallikrein 7 in Body Weight and Fat Mass Regulation. Biomedicines\| PubMed ID: 33572949	2021
Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells. Cells\| PubMed ID: 33669258	2021
First report on establishment and characterization of a carcinosarcoma tumour cell line model of the bladder. Scientific reports\| PubMed ID: 33727576	2021
A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Line... Proteomes\| PubMed ID: 34070654	2021