Robrecht Raedt

Department of Head and Skin, Ghent University

Affiliated withGhent University Ghent University Hospital

Research Area

Biography

Currently I am working as Associate Research Professor at the 4BRAIN lab of Ghent University in Belgium. In 2002, I obtained a Masters degree in Biology at Ghent University. In 2007, I completed my PhD research at the Faculty of Medicine and Health Sciences of Ghent University. The topic of his PhD research was 'Cell Therapy for Epilepsy'. This work implicated isolation and culture of stem cells, biochemical characterization of cell clones, cell grafting in various epilepsy models, immunohistochemistry, etc... . As a postdoc, also at 4BRAIN, I studied the mechanism of action of neurostimulation therapies for epilepsy (vagus nerve stimulation and deep brain stimulation) both in animal models as in patients with epilepsy. This work involved techniques such as microdialysis and intracranial electrophysiology in rats and single-unit recording in humans. Currently my main interest is optogenetic and chemogenetic modulation of epileptic brain circuits

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2022
Publication title	2025

Other Publications

Article	Year
Neurostimulation for refractory epilepsy. Acta neurologica Belgica\| PubMed ID: 15008506	2003
Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood. Seizure\| PubMed ID: 16095927	2005
Cell therapy for neurological disorders: a comprehensive review. Acta neurologica Belgica\| PubMed ID: 16255154	2005
Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam. Epilepsy research\| PubMed ID: 16289683	2005
Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy. Acta neurologica Belgica\| PubMed ID: 16898260	2006
Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers. Experimental neurology\| PubMed ID: 17078948	2007
High frequency deep brain stimulation in the hippocampus modifies seizure characteristics in kindled rats. Epilepsia\| PubMed ID: 17381435	2007
Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition. Epilepsia\| PubMed ID: 17555527	2007
Cell therapy in models for temporal lobe epilepsy. Seizure\| PubMed ID: 17566770	2007
A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy. Clinical neurology and neurosurgery\| PubMed ID: 18572306	2008
Electrical stimulation for the treatment of epilepsy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 19332313	2009
Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat. Acta neurologica Scandinavica\| PubMed ID: 19388152	2009
Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy. Journal of neuroimmunology\| PubMed ID: 19608283	2009
Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus. Epilepsy research\| PubMed ID: 19758788	2009
Predictive factors for outcome of invasive video-EEG monitoring and subsequent resective surgery in patients with refractory epilepsy. Clinical neurology and neurosurgery\| PubMed ID: 20005033	2010
Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats. Epilepsy research\| PubMed ID: 20044240	2010
Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat. NeuroImage\| PubMed ID: 20394827	2010
Quantitative analysis of adenosine using liquid chromatography/atmospheric pressure chemical ionization-tandem mass spectrometry (LC/APCI-MS/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 20409760	2010
Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery. Seizure\| PubMed ID: 20688264	2010
Evolution in VNS therapy for refractory epilepsy, experience with Demipulse devices at Ghent University Hospital. Seizure\| PubMed ID: 20702123	2010
Vagus nerve stimulation and the postictal state. Epilepsy & behavior : E&B\| PubMed ID: 20724218	2010
Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures. Epilepsia\| PubMed ID: 20726873	2010
Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation. Epilepsia\| PubMed ID: 20973781	2010
A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital. Epilepsy research\| PubMed ID: 21071177	2010
Magnetoencephalography in epilepsy patients carrying a vagus nerve stimulator. Epilepsy research\| PubMed ID: 21129918	2011
Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide. Epilepsy research\| PubMed ID: 21277169	2011
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model. Journal of neurochemistry\| PubMed ID: 21323924	2011
Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats. Journal of neuroscience methods\| PubMed ID: 21513735	2011
Automatic detection of epileptic seizures on the intra-cranial electroencephalogram of rats using reservoir computing. Artificial intelligence in medicine\| PubMed ID: 21955575	2011
Real-time detection of epileptic seizures in animal models using reservoir computing. Epilepsy research\| PubMed ID: 22854191	2013
Innovative treatments for epilepsy: radiosurgery and local delivery. Handbook of clinical neurology\| PubMed ID: 22939079	2012
Ictal-onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy. Epilepsia\| PubMed ID: 23647147	2013
Electrophysiological responses from vagus nerve stimulation in rats. International journal of neural systems\| PubMed ID: 24156670	2013
Non-pharmacological treatment options for refractory epilepsy: an overview of human treatment modalities and their potential utility in dogs. Veterinary journal (London, England : 1997)\| PubMed ID: 24309438	2014
The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats. International journal of neural systems\| PubMed ID: 24475897	2014
Regional brain perfusion changes during standard and microburst vagus nerve stimulation in dogs. Epilepsy research\| PubMed ID: 24630046	2014
The P3 event-related potential is a biomarker for the efficacy of vagus nerve stimulation in patients with epilepsy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 24711167	2014
Vagus nerve stimulation…25 years later! What do we know about the effects on cognition? Neuroscience and biobehavioral reviews\| PubMed ID: 24858008	2014
Evaluation of heart rate variability in dogs during standard and microburst vagus nerve stimulation: a pilot study. Veterinary journal (London, England : 1997)\| PubMed ID: 25296848	2014
Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 25361593	2015
The effect of vagus nerve stimulation on CSF monoamines and the PTZ seizure threshold in dogs. Brain stimulation\| PubMed ID: 25442153	2015
Vagus nerve stimulation has antidepressant effects in the kainic acid model for temporal lobe epilepsy. Brain stimulation\| PubMed ID: 25444592	2015
Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect. PloS one\| PubMed ID: 25587987	2015
Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors. Epilepsia\| PubMed ID: 25684325	2015
Subthalamic nucleus stimulation and spontaneous language production in Parkinson's disease: A double laterality problem. Brain and language\| PubMed ID: 26099950	2015
The antidepressant mechanism of action of vagus nerve stimulation: Evidence from preclinical studies. Neuroscience and biobehavioral reviews\| PubMed ID: 26116875	2015
Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain. PloS one\| PubMed ID: 26193653	2015
The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus. Journal of psychiatric research\| PubMed ID: 26228393	2015
The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring. Brain research\| PubMed ID: 26381287	2015
Modulation of Hippocampal Activity by Vagus Nerve Stimulation in Freely Moving Rats. Brain stimulation\| PubMed ID: 26481670	2016
A Preclinical Study of Laryngeal Motor-Evoked Potentials as a Marker Vagus Nerve Activation. International journal of neural systems\| PubMed ID: 26510476	2015
Responsive neurostimulation in epilepsy. Expert review of neurotherapeutics\| PubMed ID: 26580843	2015
Vagus Nerve Stimulator Placement in Dogs: Surgical Implantation Technique, Complications, Long-Term Follow-Up, and Practical Considerations. Veterinary surgery : VS\| PubMed ID: 26731597	2016
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures. Experimental neurology\| PubMed ID: 26774005	2016
Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 27102987	2016
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. Epilepsia\| PubMed ID: 27158916	2016
Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy. Expert review of neurotherapeutics\| PubMed ID: 27254399	2016
EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy. International journal of neural systems\| PubMed ID: 27712133	2017
The effect of vagus nerve stimulation on response inhibition. Epilepsy & behavior : E&B\| PubMed ID: 27743550	2016
Clinical Vagus Nerve Stimulation Paradigms Induce Pronounced Brain and Body Hypothermia in Rats. International journal of neural systems\| PubMed ID: 28178853	2017
Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. Brain : a journal of neurology\| PubMed ID: 29050390	2017
Reduced distractor interference during vagus nerve stimulation. International journal of psychophysiology : official journal of the International Organization of Psychophysiology\| PubMed ID: 29574234	2018
Recent advances in devices for vagus nerve stimulation. Expert review of medical devices\| PubMed ID: 30071175	2018
The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy. PloS one\| PubMed ID: 30629669	2019
Hypothermia Masks Most of the Effects of Rapid Cycling VNS on Rat Hippocampal Electrophysiology. International journal of neural systems\| PubMed ID: 30961408	2019
Preparing for hard times: Scalp and intracranial physiological signatures of proactive cognitive control. Psychophysiology\| PubMed ID: 31175676	2019
Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study. NeuroImage\| PubMed ID: 31473355	2019
Vagus Nerve Stimulation-Induced Laryngeal Motor Evoked Potentials: A Possible Biomarker of Effective Nerve Activation. Frontiers in neuroscience\| PubMed ID: 31507360	2019
Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy. Epilepsia\| PubMed ID: 31608439	2019
2-[F]FELP, a novel LAT1-specific PET tracer, for the discrimination between glioblastoma, radiation necrosis and inflammation. Nuclear medicine and biology\| PubMed ID: 31841816	2020
Kainic acid-induced status epilepticus decreases mGlu receptor and phase-specifically downregulates Homer1b/c expression. Brain research\| PubMed ID: 31891692	2020
Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and i... Neurobiology of disease\| PubMed ID: 32087287	2020
A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity. Frontiers in neuroscience\| PubMed ID: 32210746	2020
Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulatio... Epilepsia\| PubMed ID: 32297989	2020
Transcutaneous Vagus Nerve Stimulation Does Not Affect Verbal Memory Performance in Healthy Volunteers. Frontiers in psychology\| PubMed ID: 32351421	2020
Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects. Brain stimulation\| PubMed ID: 32454214	2020
Acute symptomatic seizures following intracerebral hemorrhage in the rat collagenase model. Epilepsy research\| PubMed ID: 32497986	2020
Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice. Sensors (Basel, Switzerland)\| PubMed ID: 32664419	2020
Development of a Rat Model for Glioma-Related Epilepsy. International journal of molecular sciences\| PubMed ID: 32977526	2020
Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome. International journal of molecular sciences\| PubMed ID: 32987703	2020
Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain. Micromachines\| PubMed ID: 33396287	2020
The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A Receptor. International journal of molecular sciences\| PubMed ID: 33396826	2020
Long-term chemogenetic suppression of seizures in a multifocal rat model of temporal lobe epilepsy. Epilepsia\| PubMed ID: 33570167	2021
Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation. Seizure\| PubMed ID: 33636552	2021
Hippocampal Sclerosis in Frontotemporal Dementia: When Vascular Pathology Meets Neurodegeneration. Journal of neuropathology and experimental neurology\| PubMed ID: 33638350	2021
Attenuation of Hippocampal Evoked Potentials by Activation of GtACR2, an Optogenetic Chloride Channel. Frontiers in neuroscience\| PubMed ID: 33854415	2021
Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research. Frontiers in neuroscience\| PubMed ID: 33927593	2021
White Matter Integrity in a Rat Model of Epileptogenesis: Structural Connectomics and Fixel-Based Analysis. Brain connectivity\| PubMed ID: 34155915	2021
Seizures and Interictal Epileptiform Activity in the Rat Collagenase Model for Intracerebral Hemorrhage. Frontiers in neuroscience\| PubMed ID: 34220437	2021
Double Two-State Opsin Model With Autonomous Parameter Inference. Frontiers in computational neuroscience\| PubMed ID: 34220478	2021
Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 34288274	2021
Comparison of In Vivo and Ex Vivo Magnetic Resonance Imaging in a Rat Model for Glioblastoma-Associated Epilepsy. Diagnostics (Basel, Switzerland)\| PubMed ID: 34441246	2021
Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus. eNeuro\| PubMed ID: 34620623	2021
Voxel-Based Analysis of [18F]-FDG Brain PET in Rats Using Data-Driven Normalization. Frontiers in medicine\| PubMed ID: 34746179	2021
Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 34862591	2021
blue light illumination for optogenetic inhibition: effect on local temperature and excitability of the rat hippocampus. Journal of neural engineering\| PubMed ID: 34951406	2021
Transcutaneous auricular vagus nerve stimulation cannot modulate the P3b event-related potential in healthy volunteers. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology\| PubMed ID: 35007840	2022
The potential of invasive and non-invasive vagus nerve stimulation to improve verbal memory performance in epilepsy patients. Scientific reports\| PubMed ID: 35132096	2022
Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 35177376	2022
Description of Osmolyte Pathways in Maturing Mice Reveals Altered Levels of Taurine and Sodium/Myo-Inositol Co-Transporters. International journal of molecular sciences\| PubMed ID: 35328671	2022
Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 35396071	2022
Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy. Frontiers in neuroscience\| PubMed ID: 35794951	2022
Continuous theta burst stimulation for drug-resistant epilepsy. Frontiers in neuroscience\| PubMed ID: 36061598	2022
Exploring the Therapeutic Potential of Ectoine in Duchenne Muscular Dystrophy: Comparison with Taurine, a Supplement with Known Beneficial Effects in the Mouse. International journal of molecular sciences\| PubMed ID: 36076964	2022
In vivo inhibition of epileptiform afterdischarges in rat hippocampus by light-activated chloride channel, stGtACR2. CNS neuroscience & therapeutics\| PubMed ID: 36482869	2023
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus. Neurobiology of disease\| PubMed ID: 37977430	2023
An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care. PloS one\| PubMed ID: 38165944	2024
Integrating and optimizing tonabersat in standard glioblastoma therapy: A preclinical study. PloS one\| PubMed ID: 38489314	2024
Vagus nerve stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination. Brain stimulation\| PubMed ID: 38648972	2024
Exploration of Theta Burst-Induced Modulation of Transcranial Magnetic Stimulation-Evoked Potentials Over the Motor Cortex. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 38842956	2025
Investigating the Working Mechanism of Transcranial Direct Current Stimulation. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 38878056	2025
Proteomics dataset of lysolecithin-induced demyelinated lesions in corpus callosum of Lewis rats, treated with Vagus nerve stimulation or sham treatment. Data in brief\| PubMed ID: 39554548	2024