Juan Chen

Princess Margaret Cancer Centre

Affiliated withPrincess Margaret Cancer Centre University Health Network

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2021
Publication title Cited by 1	2025

Other Publications

Article	Year
Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head-and-Neck Cancer Rabbit Model. Advanced healthcare materials\| PubMed ID: 26283596	2015
Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26463705	2016
Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models. Theranostics\| PubMed ID: 26681987	2015
Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging. Nanoscale\| PubMed ID: 26731304	2016
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26884153	2016
Chlorosome-Inspired Synthesis of Templated Metallochlorin-Lipid Nanoassemblies for Biomedical Applications. ACS nano\| PubMed ID: 27015124	2016
Nanotexaphyrin: One-Pot Synthesis of a Manganese Texaphyrin-Phospholipid Nanoparticle for Magnetic Resonance Imaging. Angewandte Chemie (International ed. in English)\| PubMed ID: 27071806	2016
Topical MMP beacon enabled fluorescence-guided resection of oral carcinoma. Biomedical optics express\| PubMed ID: 27231609	2016
Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery. Molecular pharmaceutics\| PubMed ID: 27700119	2016
Molecular imaging in drug development: Update and challenges for radiolabeled antibodies and nanotechnology. Methods (San Diego, Calif.)\| PubMed ID: 28743635	2017
Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 29110850	2017
Effect of removing Kupffer cells on nanoparticle tumor delivery. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29208719	2017
Multipronged Biomimetic Approach To Create Optically Tunable Nanoparticles. Angewandte Chemie (International ed. in English)\| PubMed ID: 29752766	2018
Porphysomes: Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head-and-Neck Cancer Rabbit Model (Adv. Healthcare Mater. 14/2015). Advanced healthcare materials\| PubMed ID: 29896901	2015
Mixed and Matched Metallo-Nanotexaphyrin for Customizable Biomedical Imaging. Advanced healthcare materials\| PubMed ID: 30211482	2019
Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma. International journal of oncology\| PubMed ID: 30226590	2018
Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy. The Annals of thoracic surgery\| PubMed ID: 30316853	2019
Tuning Pharmacokinetics to Improve Tumor Accumulation of a Prostate-Specific Membrane Antigen-Targeted Phototheranostic Agent. Bioconjugate chemistry\| PubMed ID: 30350576	2018
Evaluation of Novel Imaging Devices for Nanoparticle-Mediated Fluorescence-Guided Lung Tumor Therapy. The Annals of thoracic surgery\| PubMed ID: 30742818	2019
Tailoring Porphyrin Conjugation for Nanoassembly-Driven Phototheranostic Properties. ACS nano\| PubMed ID: 30916932	2019
Stable J-Aggregation of an aza-BODIPY-Lipid in a Liposome for Optical Cancer Imaging. Angewandte Chemie (International ed. in English)\| PubMed ID: 31344292	2019
A Nanoemulsion with A Porphyrin Shell for Cancer Theranostics. Angewandte Chemie (International ed. in English)\| PubMed ID: 31410962	2019
Long-Circulating Prostate-Specific Membrane Antigen-Targeted NIR Phototheranostic Agent. Photochemistry and photobiology\| PubMed ID: 31742696	2020
Photodynamic therapy enables tumor-specific ablation in preclinical models of thyroid cancer. Endocrine-related cancer\| PubMed ID: 31751308	2020
Clearance of two organic nanoparticles from the brain via the paravascular pathway. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 32165238	2020
Photophysics of J-Aggregating Porphyrin-Lipid Photosensitizers in Liposomes: Impact of Lipid Saturation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 32338515
Lipoprotein-Like Nanoparticle Carrying Small Interfering RNA Against Spalt-Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden. Hepatology communications\| PubMed ID: 32363325	2020
The dose threshold for nanoparticle tumour delivery. Nature materials\| PubMed ID: 32778816	2020
Subtherapeutic Photodynamic Treatment Facilitates Tumor Nanomedicine Delivery and Overcomes Desmoplasia. Nano letters\| PubMed ID: 33301689	2021
A preclinical research platform to evaluate photosensitizers for transbronchial localization and phototherapy of lung cancer using an orthotopic mouse model. Translational lung cancer research\| PubMed ID: 33569308	2021
Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy. Journal of nanobiotechnology\| PubMed ID: 34034749	2021
Attenuation of nontargeted cell-kill using a high-density lipoprotein-mimicking peptide--phospholipid nanoscaffold. Nanomedicine (London, England)\| PubMed ID: 21718175	2011
Multimodal bacteriochlorophyll theranostic agent. Theranostics\| PubMed ID: 21938263	2011
Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer. Theranostics\| PubMed ID: 21938264	2011
Efficient systemic delivery of siRNA by using high-density lipoprotein-mimicking peptide lipid nanoparticles. Nanomedicine (London, England)\| PubMed ID: 22830501	2012
Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly. ACS nano\| PubMed ID: 23394589	2013
Biologically-targeted detection of primary and micro-metastatic ovarian cancer. Theranostics\| PubMed ID: 23781288	2013
Lipid-based nanoparticles in the systemic delivery of siRNA. Nanomedicine (London, England)\| PubMed ID: 24354813	2014
Targeting-triggered porphysome nanostructure disruption for activatable photodynamic therapy. Advanced healthcare materials\| PubMed ID: 24464930	2014
Learning from biology: synthetic lipoproteins for drug delivery. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 25346461	2015
A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics. ACS nano\| PubMed ID: 25830219	2015
Using Fluorescence Imaging to Track Drug Delivery and Guide Treatment Planning In Vivo. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27283425	2016
Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study. Journal of biomedical optics\| PubMed ID: 27552306	2016
QUANTIFYING NANOPARTICLE TRANSPORT USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER. Journal of innovative optical health sciences\| PubMed ID: 28855967	2012
Personalized siRNA-Nanoparticle Systemic Therapy using Metastatic Lymph Node Specimens Obtained with EBUS-TBNA in Lung Cancer. Molecular cancer research : MCR\| PubMed ID: 28993508	2018
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Cell death & disease\| PubMed ID: 30741932	2019
Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer. Theranostics\| PubMed ID: 31131064	2019
Novel Pyropheophorbide Phosphatydic Acids Photosensitizer Combined EGFR siRNA Gene Therapy for Head and Neck Cancer Treatment. Pharmaceutics\| PubMed ID: 34575510	2021
Complex cellular environments imaged by SERS nanoprobes using sugars as an all-in-one vector. Journal of materials chemistry. B\| PubMed ID: 34709285	2021
Rabbit VX2 head and neck squamous cell models for translational head and neck theranostic technology development. Clinical and translational medicine\| PubMed ID: 34709737	2021
A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain. Frontiers in pharmacology\| PubMed ID: 36046828	2022
Prolonged Circulating Lipid Nanoparticles Enabled by High-Density Gd-DTPA-Bis(stearylamide) for Long-Lasting Enhanced Tumor Magnetic Resonance Imaging. Bioconjugate chemistry\| PubMed ID: 36306468	2022
Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36346844	2022
Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect. Nanophotonics (Berlin, Germany)\| PubMed ID: 36405502	2021
Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy. Biomaterials\| PubMed ID: 36442438	2023
Organization of the Interfacial Film of Nanoemulsions Stabilized by Porphyrin Derivatives. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 36680520	2023
Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy. Angewandte Chemie (International ed. in English)\| PubMed ID: 36811315	2023
Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles. ACS nano\| PubMed ID: 36853331	2023
Protease-Activatable Porphyrin Molecular Beacon for Osteoarthritis Management. Chemical & biomedical imaging\| PubMed ID: 37122828	2023
Nanostructure-Driven Indocyanine Green Dimerization Generates Ultra-Stable Phototheranostics Nanoparticles. Angewandte Chemie (International ed. in English)\| PubMed ID: 37162307	2023
Effective treatment of metastatic sentinel lymph nodes by dual-targeting melittin nanoparticles. Journal of nanobiotechnology\| PubMed ID: 37528426	2023
Photochemical synthesis of fluorescent Au(RGDC) and excited state reactivity with molecular oxygen. Nanoscale\| PubMed ID: 37551778	2023
Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy. Nature communications\| PubMed ID: 37794000	2023
Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 38032129	2024
Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models. Cancer research communications\| PubMed ID: 38421899	2024
Photodynamic therapy of cancer-associated infections. Photochemistry and photobiology\| PubMed ID: 39737809	2024
Diving into Unknown Waters: Water-Soluble Clickable Au Nanoclusters Protected with N-Heterocyclic Carbenes for Bio-Medical Applications. Journal of the American Chemical Society\| PubMed ID: 39841626	2025
Impact of Ligand Structure on Biological Activity and Photophysical Properties of NHC-Protected Au Nanoclusters. Journal of the American Chemical Society\| PubMed ID: 39841867	2025