Leonid Kruglyak

Howard Hughes Medical Institute

Affiliated withHoward Hughes Medical Institute University of California Los Angeles

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2021

Other Publications

Article	Year
Efficient multipoint linkage analysis through reduction of inheritance space. American journal of human genetics\| PubMed ID: 11254453	2001
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. American journal of human genetics\| PubMed ID: 11438886	2001
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. American journal of human genetics\| PubMed ID: 11473344	2001
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. American journal of human genetics\| PubMed ID: 11870593	2002
Genetic dissection of transcriptional regulation in budding yeast. Science (New York, N.Y.)\| PubMed ID: 11923494	2002
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. American journal of human genetics\| PubMed ID: 12844283	2003
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature genetics\| PubMed ID: 12897782	2003
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American journal of human genetics\| PubMed ID: 14681826	2004
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. American journal of human genetics\| PubMed ID: 15015130	2004
Sequence-based linkage analysis. American journal of human genetics\| PubMed ID: 15329798	2004
No bias in linkage analysis. American journal of human genetics\| PubMed ID: 15338460	2004
Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome research\| PubMed ID: 15545498	2004
The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15659551	2005
Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome research\| PubMed ID: 15687292	2005
Local regulatory variation in Saccharomyces cerevisiae. PLoS genetics\| PubMed ID: 16121257	2005
Revealing complex traits with small molecules and naturally recombinant yeast strains. Chemistry & biology\| PubMed ID: 16638537	2006
Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nature genetics\| PubMed ID: 17334364	2007
Genetics. It's the sequence, stupid! Science (New York, N.Y.)\| PubMed ID: 18927376	2008
Comparative developmental expression profiling of two C. elegans isolates. PloS one\| PubMed ID: 19116648	2008
A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science (New York, N.Y.)\| PubMed ID: 19150845	2009
Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature\| PubMed ID: 19212320	2009
Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron\| PubMed ID: 19285466	2009
A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics (Oxford, England)\| PubMed ID: 19389736	2009
Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC genomics\| PubMed ID: 19435513	2009
Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics\| PubMed ID: 19581448	2009
Protein quantification across hundreds of experimental conditions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19717460	2009
Using expression and genotype to predict drug response in yeast. PloS one\| PubMed ID: 19730698	2009
Finding the missing heritability of complex diseases. Nature\| PubMed ID: 19812666	2009
Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080586	2010
Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature\| PubMed ID: 20393561	2010
Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science (New York, N.Y.)\| PubMed ID: 20947766	2010
Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature\| PubMed ID: 21412235	2011
Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome biology\| PubMed ID: 22182234	2011
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nature genetics\| PubMed ID: 22286215	2012
Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science (New York, N.Y.)\| PubMed ID: 22301316	2012
Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science (New York, N.Y.)\| PubMed ID: 22773140	2012
More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics\| PubMed ID: 23086219	2012
Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC biology\| PubMed ID: 23114012	2012
Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS genetics\| PubMed ID: 23284308	2012
Finding the sources of missing heritability in a yeast cross. Nature\| PubMed ID: 23376951	2013
Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda, Md.)\| PubMed ID: 23550140	2013
Genetics of single-cell protein abundance variation in large yeast populations. Nature\| PubMed ID: 24402228	2014
A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS genetics\| PubMed ID: 24586193	2014
Genetic basis of metabolome variation in yeast. PLoS genetics\| PubMed ID: 24603560	2014
Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics\| PubMed ID: 25189874	2014
Genetic influences on translation in yeast. PLoS genetics\| PubMed ID: 25340754	2014
Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS genetics\| PubMed ID: 25521586	2014
Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. PLoS genetics\| PubMed ID: 25569670	2015
A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS pathogens\| PubMed ID: 25680197	2015
The role of regulatory variation in complex traits and disease. Nature reviews. Genetics\| PubMed ID: 25707927	2015
A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda, Md.)\| PubMed ID: 25770127	2015
Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome research\| PubMed ID: 25783854	2015
Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics\| PubMed ID: 25995208	2015
Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics\| PubMed ID: 26092720	2015
Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nature communications\| PubMed ID: 26537231	2015
2015 Curt Stern Award. American journal of human genetics\| PubMed ID: 26942280	2016
CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science (New York, N.Y.)\| PubMed ID: 27230379	2016
Complex Traits and Simple Systems: An Interview with Leonid Kruglyak. Genetics\| PubMed ID: 27384025	2016
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics\| PubMed ID: 27449056	2016
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nature genetics\| PubMed ID: 28250458	2017
A maternal-effect selfish genetic element in . Science (New York, N.Y.)\| PubMed ID: 28495877	2017
A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science (New York, N.Y.)\| PubMed ID: 28572335	2017
The genetic basis of natural variation in a phoretic behavior. Nature communications\| PubMed ID: 28819099	2017
Highly parallel genome variant engineering with CRISPR-Cas9. Nature genetics\| PubMed ID: 29632376	2018
Genetics of -regulatory variation in gene expression. eLife\| PubMed ID: 30014850	2018
The Genetic Basis of Mutation Rate Variation in Yeast. Genetics\| PubMed ID: 30504363	2019
How Low Can You Go? The CRISPR journal\| PubMed ID: 31021269	2018
Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nature communications\| PubMed ID: 31213597	2019
Analysis of the genetic basis of height in large Jewish nuclear families. PLoS genetics\| PubMed ID: 31283753	2019
Rare variants contribute disproportionately to quantitative trait variation in yeast. eLife\| PubMed ID: 31647408	2019
Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell\| PubMed ID: 31761530	2019
Toxin-Antidote Elements Across the Tree of Life. Annual review of genetics\| PubMed ID: 32886546	2020
Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv : the preprint server for health sciences\| PubMed ID: 32909008	2021
Systematic identification of -regulatory variants that cause gene expression differences in a yeast cross. eLife\| PubMed ID: 33179598	2020
Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. Current biology : CB\| PubMed ID: 33417886	2021
Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast. Science (New York, N.Y.)\| PubMed ID: 33479156	2021
Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. eLife\| PubMed ID: 33734084	2021
Retrospective Detection of SARS-CoV-2 in Symptomatic Patients prior to Widespread Diagnostic Testing in Southern California. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 33939799	2021
Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS genetics\| PubMed ID: 34166378	2021
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nature biomedical engineering\| PubMed ID: 34211145	2021