Sarah K. Wootton

Sarah K. Wootton

Department of Pathobiology, University of Guelph

Affiliated withUniversity of Guelph

Research Area

Biography

Dr. Wootton obtained her Ph.D. from the University of Guelph in 2002 before completing a post-doctoral fellowship at the Fred Hutchinson Cancer Research Center in Seattle, Washington where she studied lung gene therapy and oncogenic retroviruses in the laboratory of Dr. Dusty Miller. In September 2007, Dr. Wootton joined the faculty at the University of Guelph and is now an Associate Professor of Virology in the Department of Pathobiology. The overarching goal of research in her lab is to engineer viral therapies to prevent, treat or cure illnesses including monogenic disorders, infectious diseases and cancer. One of her core research areas focuses on adeno-associated virus (AAV) vectors. Work in her lab centers on developing a AAV vectors for the treatment of monogenic lung diseases, such as surfactant protein B deficiency and cystic fibrosis, as well as developing AAV vectors for “Vectored Immunoprophylaxis” or VIP, a method to deliver broadly neutralizing monoclonal antibody against pathogens which lack suitable vaccines or therapies.

JoVE Journal Publications

ArticleTotal : 2
Year
Production of Adeno-Associated Virus Vectors in Cell Stacks for Preclinical Studies in Large Animal Models
Publication title

Cited by 17

2021
2022

Other Publications

Article
Year
Antigenic structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus.

Clinical and diagnostic laboratory immunology| PubMed ID: 9801333

1998
2002
2003
2003
2010
2011
2012
Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research| PubMed ID: 23458611

2013
2013
2013
2014
2014
2014
2014
2015
Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire| PubMed ID: 25673902

2015
2016
2016
2017
2016
Prevalence of small ruminant lentivirus and subsp. co-infection in Ontario dairy sheep and dairy goats.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire| PubMed ID: 28408784

2017
2017
2017
2018
2018
2018
2018
2018
2018
Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 30206160

2019
2018
AAV-Mediated Gene Delivery to the Lung.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 30783985

2019
Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies.

Molecular therapy. Methods & clinical development| PubMed ID: 30788384

2019
2019
2020
Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies.

Molecular therapy. Methods & clinical development| PubMed ID: 31388514

2019
2019
2020
2020
2020
2020
2020
Tumour vasculature: Friend or foe of oncolytic viruses?

Cytokine & growth factor reviews| PubMed ID: 32893095

2020
2020
2020
AAV Vectored Immunoprophylaxis for Filovirus Infections.

Tropical medicine and infectious disease| PubMed ID: 33182447

2020
2021
2021
Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils.

International journal of molecular sciences| PubMed ID: 33946935

2021
2021
2021
Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration.

American journal of respiratory cell and molecular biology| PubMed ID: 34241584

2021
2021
2021
2021
2021
Production and purification of high-titer OrfV for preclinical studies in vaccinology and cancer therapy.

Molecular therapy. Methods & clinical development| PubMed ID: 34786436

2021
2022
2021
2021
2022
2022