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<em>In vivo</em> Function of Differential Subsets of Cutaneous Dendritic Cells to Induce Th17 Immunity in Intradermal <em>Candida albicans</em> Infection

The skin is the outermost barrier organ in the body, which contains several types of dendritic cells (DCs), a group of professional antigen-presenting ...

Yonsei University College of Medicine

Up-regulation of receptor antagonist interleukin-1 family members in psoriasis and their regulation by pro-inflammatory cytokines.

Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from dendritic cell (DC)-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non-lymphoid barrier tissues such as skin. However, whether CD301b DCs in the skin represent an ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Here, we demonstrated that CD301b dermal DCs were distinct subpopulation of FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent CD11b cDC2 lineage, which required an additional GM-CSF cue for the adequate development. Although the majority of lymphoid-resident cDC2 lacked CD301b expression, dermal migratory cDC2 contained a substantial fraction of CD301b subset. Similar to CD301b population, CD301b dermal DC development was closely regulated by FLT3 signaling, suggesting their common origin from FLT3L-responsive cDC progenitors. However, FLT3L-driven cDC progenitor culture was not sufficient, but additional GM-CSF treatment was required to produce CD301b cDC2. In vivo development of CD301b cDC2 was significantly augmented by exogenous GM-CSF, while the repopulation of CD301b dermal cDC2 was abrogated by GM-CSF neutralization. Functionally, CD301b cDC2 was capable of producing a high level of IL-23, and the depletion of CD301b cDC2 effectively prevented IL-17-mediated psoriasiform dermatitis. Therefore, our findings highlight the differentiation program of a distinct CD301b dermal cDC2 subset in the skin and its involvement in psoriatic inflammation.

Skin-Specific CD301b Dermal Dendritic Cells Drive IL-17-Mediated Psoriasis-Like Immune Response in Mice.

Langerhans cells (LCs) are dendritic cells that reside in the epidermis and local inflammation results in an increased differentiation of monocyte-derived LCs. Only few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the results are variable and the exact role of LCs in psoriasis model remains to be elucidated.

Article	Year
Up-regulation of receptor antagonist interleukin-1 family members in psoriasis and their regulation by pro-inflammatory cytokines. Journal of dermatological science\| PubMed ID: 26917344	2016
Skin-Specific CD301b Dermal Dendritic Cells Drive IL-17-Mediated Psoriasis-Like Immune Response in Mice. The Journal of investigative dermatology\| PubMed ID: 29138056	2018
Resident and monocyte-derived Langerhans cells are required for imiquimod-induced psoriasis-like dermatitis model. Journal of dermatological science\| PubMed ID: 29655588	2018

Jeyun Park

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