David A. Tuveson

Cold Spring Harbor Laboratory

Affiliated withCold Spring Harbor Laboratory

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2022

Other Publications

Article	Year
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. The Journal of clinical investigation\| PubMed ID: 21965329	2011
SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut\| PubMed ID: 24067278	2014
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma. OncoTargets and therapy\| PubMed ID: 24379681	2013
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. BioMed research international\| PubMed ID: 25147816	2014
The RAS and YAP1 dance, who is leading? The EMBO journal\| PubMed ID: 25257311	2014
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell\| PubMed ID: 25259922	2014
p53 mutations change phosphatidylinositol acyl chain composition. Cell reports\| PubMed ID: 25543136	2015
Organoid models of human and mouse ductal pancreatic cancer. Cell\| PubMed ID: 25557080	2015
Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma. The Journal of pathology\| PubMed ID: 25561062	2015
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25624498	2015
ADAM8 as a drug target in pancreatic cancer. Nature communications\| PubMed ID: 25629724	2015
Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut\| PubMed ID: 25994217	2015
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Scientific reports\| PubMed ID: 26046460	2015
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell\| PubMed ID: 26144316	2015
Mouse Models of Pancreatic Ductal Adenocarcinoma. Hematology/oncology clinics of North America\| PubMed ID: 26226900	2015
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut\| PubMed ID: 26347531	2016
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of pathology\| PubMed ID: 26419819	2015
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nature communications\| PubMed ID: 26522614	2015
Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26573598	2016
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nature cell biology\| PubMed ID: 27088855	2016
Modeling pancreatic cancer with organoids. Trends in cancer\| PubMed ID: 27135056	2016
Pancreatic cancer. Nature reviews. Disease primers\| PubMed ID: 27158978	2016
Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget\| PubMed ID: 27244881	2016
Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & cellular oncology\| PubMed ID: 27308531	2016
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell\| PubMed ID: 27477511	2016
ROS in translation: Chink in the armor. Cell cycle (Georgetown, Tex.)\| PubMed ID: 27636545	2017
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. Cancer research\| PubMed ID: 27742686	2016
Cancer: Double trouble for tumours. Nature\| PubMed ID: 28099410	2017
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nature communications\| PubMed ID: 28224990	2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. The Journal of experimental medicine\| PubMed ID: 28232471	2017
Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nature genetics\| PubMed ID: 28232730	2017
Challenges and Opportunities in Modeling Pancreatic Cancer. Cold Spring Harbor symposia on quantitative biology\| PubMed ID: 28289164	2016
ROS in Cancer: The Burning Question. Trends in molecular medicine\| PubMed ID: 28427863	2017
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nature genetics\| PubMed ID: 28481342	2017
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell\| PubMed ID: 28757253	2017
Transcriptional Regulation by Nrf2. Antioxidants & redox signaling\| PubMed ID: 28899199	2018
Soils and Seeds That Initiate Pancreatic Cancer Metastasis. Cancer discovery\| PubMed ID: 28974531	2017
Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointestinal endoscopy\| PubMed ID: 29325707	2018
Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer research\| PubMed ID: 29789416	2018
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer discovery\| PubMed ID: 29853643	2018
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Cancer discovery\| PubMed ID: 29903880	2018
Stromal biology and therapy in pancreatic cancer: ready for clinical translation? Gut\| PubMed ID: 30177543	2019
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer discovery\| PubMed ID: 30366930	2019
Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30378047	2019
Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30378048	2019
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell reports\| PubMed ID: 30428345	2018
Deciphering cancer fibroblasts. The Journal of experimental medicine\| PubMed ID: 30470718	2018
Organoid models for translational pancreatic cancer research. Current opinion in genetics & development\| PubMed ID: 30844513	2019
A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth. Cancer discovery\| PubMed ID: 31043410	2019
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy. Cancer discovery\| PubMed ID: 31053628	2019
Cancer modeling meets human organoid technology. Science (New York, N.Y.)\| PubMed ID: 31171691	2019
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. Cancer discovery\| PubMed ID: 31197017	2019
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science (New York, N.Y.)\| PubMed ID: 31221853	2019
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer. Cancer discovery\| PubMed ID: 31263025	2019
Perspectives on the role of Wnt biology in cancer. Science signaling\| PubMed ID: 31289213	2019
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31484774	2019
Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31492749	2019
Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31527169	2019
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell reports\| PubMed ID: 31665640	2019
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nature genetics\| PubMed ID: 31932696	2020
A framework for advancing our understanding of cancer-associated fibroblasts. Nature reviews. Cancer\| PubMed ID: 31980749	2020
Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer cell\| PubMed ID: 31983610	2020
Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 32029550	2020
Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nature genetics\| PubMed ID: 32051610	2020
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature\| PubMed ID: 32076273	2020
Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 32119924	2021
Roadmap for the Emerging Field of Cancer Neuroscience. Cell\| PubMed ID: 32302564	2020
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. eLife\| PubMed ID: 32329713	2020
The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research. Cancer discovery\| PubMed ID: 32404307	2020
SIRT1-NOX4 signaling axis regulates cancer cachexia. The Journal of experimental medicine\| PubMed ID: 32441762	2020
Diversity and Biology of Cancer-Associated Fibroblasts. Physiological reviews\| PubMed ID: 32466724	2021
Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series. Gut\| PubMed ID: 32499303	2020
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. The Journal of experimental medicine\| PubMed ID: 32633781	2020
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma. eLife\| PubMed ID: 32648540	2020
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer. Annals of surgery\| PubMed ID: 32657929	2020
Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Cancer discovery\| PubMed ID: 32703770	2020
Pancreatic cancer SLUGged. The Journal of experimental medicine\| PubMed ID: 32813872	2020
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI insight\| PubMed ID: 32990679	2020
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer. Gastroenterology\| PubMed ID: 33039466	2021
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. Nature communications\| PubMed ID: 33087697	2020
Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 33093149	2021
Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 33495315	2021
Fighting the Sixth Decade of the Cancer War with Better Cancer Models. Cancer discovery\| PubMed ID: 33811115	2021
Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34021083	2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature communications\| PubMed ID: 34099731	2021