Bengt Winblad

Bengt Winblad

Department of Neuroscience Care and Society, Karolinska Institutet

Affiliated withKarolinska InstitutetKarolinska University Hospital

Research Area

Biography

Professor Bengt Winblad was until 2018 Head of the Division of Neurogeriatrics at Karolinska Institutet. He is currently leading his own research group in the same division, focusing on drug development. Bengt Winblad is Professor of Geriatric Medicine at Karolinska Institutet in Solna and Chief Physician at Karolinska University Hospital in Huddinge. 2001-2019, he chaired the European Alzheimer Disease Consortium (EADC), currently consisting of 71 clinical research centers across Europe. Since 2009, he is a member of the Senate for the German national network on neurodegenerative disorders, DZNE. He was PI of the first EU Joint Program project, BIOMARKAPD aiming at standardizing sampling and measurement of biomarkers in Alzheimer and Parkinson disease. He has been given numerous international and national awards for his research. He has founded a number of international conferences, eg the ”International Conference of Alzheimer’s Disease (ICAD, renamed AAIC) and the International PharmacoEconomic Conferences on AD (IPECAD). He was a member of the Nobel Assembly, Karolinska Institutet 1988 – 2010. In 2009, he was recognized the world’s most prolific researcher in AD by the Journal of Alzheimer’s Disease and in 2016, he was recognized as one (out of five from Karolinska Institutet) of the most cited scientists worldwide.

JoVE Journal Publications

ArticleTotal : 1
Year
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Publication title

Cited by 4

2021

Other Publications

Article
Year
The antidepressant and antiinflammatory effects of rolipram in the central nervous system.

CNS drug reviews| PubMed ID: 11830756

2001
2002
2003
2003
2004
2005
A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 16199521

2005
2006
2006
2007
2007
Occludin is overexpressed in Alzheimer's disease and vascular dementia.

Journal of cellular and molecular medicine| PubMed ID: 17635647

2007
2007
Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.

Journal of cellular and molecular medicine| PubMed ID: 18318693

2008
2008
The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 18631976

2008
Therapeutic use of nicergoline.

Clinical drug investigation| PubMed ID: 18666801

2008
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18757748

2008
Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease.

Expert opinion on drug delivery| PubMed ID: 19040398

2008
Donepezil in severe Alzheimer's disease.

American journal of Alzheimer's disease and other dementias| PubMed ID: 19246572

2009
2011
The rat as an animal model of Alzheimer's disease.

Journal of cellular and molecular medicine| PubMed ID: 19432812

2009
Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry| PubMed ID: 19454849

2009
2009
Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease.

Journal of cellular and molecular medicine| PubMed ID: 19538474

2010
2009
Leisure activities in late life in relation to dementia risk: principal component analysis.

Dementia and geriatric cognitive disorders| PubMed ID: 19690416

2009
2011
2009
2010
Low diastolic pressure and risk of dementia in very old people: a longitudinal study.

Dementia and geriatric cognitive disorders| PubMed ID: 19752556

2009
Affinity pulldown of γ-secretase and associated proteins from human and rat brain.

Journal of cellular and molecular medicine| PubMed ID: 19754663

2010
2010
2009
2010
2010
2010
2010
The worldwide societal costs of dementia: Estimates for 2009.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 20298969

2010
2010
2010
Rethinking Alzheimer's disease therapy: are mitochondria the key?

Journal of Alzheimer's disease : JAD| PubMed ID: 20463405

2010
2010
2010
Alzheimer's disease: clinical trials and drug development.

The Lancet. Neurology| PubMed ID: 20610346

2010
2010
Association of Omi/HtrA2 with γ-secretase in mitochondria.

Neurochemistry international| PubMed ID: 20705111

2010
2010
2010
Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 20833873

2011
2010
2010
2011
2010
2011
Phenserine efficacy in Alzheimer's disease.

Journal of Alzheimer's disease : JAD| PubMed ID: 20930279

2010
Memantine benefits functional abilities in moderate to severe Alzheimer's disease.

The journal of nutrition, health & aging| PubMed ID: 21085908

2010
2011
2011
2011
2011
2011
2011
2011
Predictors of costs of care in Alzheimer's disease: a multinational sample of 1222 patients.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 21575872

2011
Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells.

Nanomedicine : nanotechnology, biology, and medicine| PubMed ID: 21703989

2011
2011
2011
2012
2012
2011
Depression in dementia: epidemiology, mechanisms, and treatment.

Current opinion in psychiatry| PubMed ID: 21926624

2011
2012
2012
2012
A novel approach for Aβ₁₋₄₀ quantification using immuno-PCR.

Journal of neuroscience methods| PubMed ID: 22327103

2012
2012
Psychosocial stress at work is associated with increased dementia risk in late life.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 22404853

2012
2012
2013
2012
2012
2012
2012
2012
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.

Biochemical and biophysical research communications| PubMed ID: 22771797

2012
2012
2013
Application of Resource Utilization in Dementia (RUD) instrument in a global setting.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 23142433

2013
2013
The worldwide economic impact of dementia 2010.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 23305821

2013
2013
2013
2013
2013
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 23620518

2013
2013
2013
The role of protein glycosylation in Alzheimer disease.

The FEBS journal| PubMed ID: 24279329

2014
2020
Neuropathologic assessment of dementia markers in identical and fraternal twins.

Brain pathology (Zurich, Switzerland)| PubMed ID: 24450926

2014
Active immunotherapy options for Alzheimer's disease.

Alzheimer's research & therapy| PubMed ID: 24476230

2014
2014
Vitamin D in relation to cognitive impairment, cerebrospinal fluid biomarkers, and brain volumes.

The journals of gerontology. Series A, Biological sciences and medical sciences| PubMed ID: 24568931

2014
Long-term metformin usage and cognitive function among older adults with diabetes.

Journal of Alzheimer's disease : JAD| PubMed ID: 24577463

2014
2014
2014
2014
2014
2014
2014
2014
2015
2014
2015
2014
2014
2014
Subjective cognitive impairment subjects in our clinical practice.

Dementia and geriatric cognitive disorders extra| PubMed ID: 25538726

2014
2015
2015
2015
2015
2015
2015
2015
Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 26079415

2015
2015
Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia.

Brain : a journal of neurology| PubMed ID: 26133663

2015
Brain health: a primary health care viewpoint.

Journal of the American Medical Directors Association| PubMed ID: 26170039

2015
2015
2015
ADAM10 and BACE1 are localized to synaptic vesicles.

Journal of neurochemistry| PubMed ID: 26296617

2015
Brain health: the importance of recognizing cognitive impairment: an IAGG consensus conference.

Journal of the American Medical Directors Association| PubMed ID: 26315321

2015
A Practical Guide to Immunoassay Method Validation.

Frontiers in neurology| PubMed ID: 26347708

2015
2015
Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia Registry.

Journal of Alzheimer's disease : JAD| PubMed ID: 26402118

2015
2015
2016
2016
2015
2015
2016
Perforin Promotes Amyloid Beta Internalisation in Neurons.

Molecular neurobiology| PubMed ID: 26780457

2017
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
2016
The worldwide costs of dementia 2015 and comparisons with 2010.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 27583652

2017
2017
2017
2017
2017
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 28216393

2017
2017
2017
2017
2017
2017
Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 28341065

2017
Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 28341066

2017
2017
Consensus guidelines for lumbar puncture in patients with neurological diseases.

Alzheimer's & dementia (Amsterdam, Netherlands)| PubMed ID: 28603768

2017
2017
Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 28709123

2017
2017
2017
2017
2017
2017
2017
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societie...

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry| PubMed ID: 29076399

2018
2017
2018
2018
2018
Apolipoprotein E genotypes and longevity across dementia disorders.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 29548722

2018
2018
2018
2018
2019
2018
2018
2018
2018
2019
2019
2019
2019
2019
2019
2019
A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD| PubMed ID: 31524172

2019
2019
2019
2019
2019
Restoring synaptic function through multimodal therapeutics.

Progress in molecular biology and translational science| PubMed ID: 31699320

2019
2020
2020
2020
2020
2020
2020
2020
2020
2020
2020
2020
2021
2020
2020
2020
2021
The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.

European journal of nuclear medicine and molecular imaging| PubMed ID: 33688996

2021
2021
Identification of undiagnosed dementia cases using a web-based pre-screening tool: The MOPEAD project.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 33860599

2021
Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons.

International journal of molecular sciences| PubMed ID: 33926107

2021
2021
Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe.

Alzheimer's & dementia : the journal of the Alzheimer's Association| PubMed ID: 33984176

2021
2021