Luis E. S. Netto

Luis E. S. Netto

Departamento de Genética e Biologia Evolutiva, Universidade De São Paulo (USP)

Affiliated withUniversidade De São Paulo (USP)Universidade de São Paulo

Research Area

Biography

I attended the University of Sao Paulo (Bacharel Degree in Biology, 1987; Ph.D. in 1992, under the guidance of Dr. Ohara Augusto) and performed an interchanged program in the Eppley Institute - Nebraska, in collaboration with Dr. Ercole Cavalieri. I was a NIH Postdoctoral Fellow, in collaboration with Dr. Stadtman from 1992 to 1996. I was Professor at State University of Campinas (Brazil) from 1996 to 1997. I am currently Full Professor at Biosciences Institute –University of Sao Paulo (Brazil). I received a prize from the Governor of Sao Paulo State for participation in the Xylella fastidiosa Genome Project (2000). I was head of Department of Genetics and Evolutionary Biology –2013-2017. I am member of the SfRBM council (since 2013).

My research interests are on thiol-based proteins with emphasis in peroxiredoxin enzymes, using the yeast Saccharomyces cerevisiae as a model organism. The response to oxidative stress is also studied in bacteria, with emphasis in Xylella fastidiosa (bacterial plant pathogen) and Pseudomonas aeruginosa. We are characterizing biochemically and structurally a new class of antioxidant enzymes: Ohr (“Organic Hydroperoxide Resistance protein) that are potential targets for drug development. We pursue the structural and functional relationships of Cys-based proteins, employing multiple approaches.

JoVE Journal Publications

ArticleTotal : 1
Year
Assessment of Submitochondrial Protein Localization in Budding Yeast <em>Saccharomyces cerevisiae</em>
Publication title

Cited by 1

2021

Other Publications

Article
Year
Thiol enzymes protecting mitochondria against oxidative damage.

Methods in enzymology| PubMed ID: 11885279

2002
2003
2004
2006
2006
Reactive cysteine in proteins: protein folding, antioxidant defense, redox signaling and more.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP| PubMed ID: 17045551

2007
Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 17110466

2007
Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17360337

2007
2008
2009
2010
2011
2011
Redox control of 20S proteasome gating.

Antioxidants & redox signaling| PubMed ID: 22229461

2012
2012
2013
2013
2014
2015
2016
2016
Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 28028230

2017
Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.

The Journal of biological chemistry| PubMed ID: 28348082

2017
2017
2017
2018
2018
2018
2019
2019
2018
2019
2019
2019
2020
2020
2020
2021
Relevance of peroxiredoxins in pathogenic microorganisms.

Applied microbiology and biotechnology| PubMed ID: 34258640

2021