Christopher L. Axelrod

Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center

Affiliated withPennington Biomedical Research Center

Research Area

Biography

Christopher Axelrod is the director of the Integrative Physiology and Molecular Medicine laboratory at Pennington Biomedical Research Center in Baton Rouge, Louisiana. His research applies a bioenergetic lens to understanding the pathogenesis and treatment of complex metabolic diseases such as insulin resistance, obesity, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Research interests include the development and testing of mitochondrial targeted pharmacotherapies, redox homeostasis in aging and disease, and therapeutic applications of metabolic surgery.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 30153426	2018
Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype. Acta physiologica (Oxford, England)\| PubMed ID: 30408342	2019
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats. Obesity surgery\| PubMed ID: 30809769	2019
UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans. Physiological reports\| PubMed ID: 31758610	2019
Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD. Medicine and science in sports and exercise\| PubMed ID: 32028458	2020
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study. The European respiratory journal\| PubMed ID: 32108049	2020
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 32396388	2020
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes\| PubMed ID: 32409493	2020
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO molecular medicine\| PubMed ID: 32519812	2020
Roux-en-Y Gastric Bypass Restores Islet Function and Morphology Independent of Body Weight in ZDF Rats. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 33427046	2021
Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults with Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 33870426	2021
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans. Metabolism: clinical and experimental\| PubMed ID: 34090870	2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Disease models & mechanisms\| PubMed ID: 34160014	2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Disease models & mechanisms\| PubMed ID: 34296742	2021