John P. Kirwan

Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center

Affiliated withPennington Biomedical Research Center Case Western Reserve University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes. Experimental physiology\| PubMed ID: 29766601	2018
Mechanisms Responsible for Metabolic Improvements of Bariatric Surgeries. Diabetes\| PubMed ID: 29784652	2018
Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 30153426	2018
Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype. Acta physiologica (Oxford, England)\| PubMed ID: 30408342	2019
Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes. Acta diabetologica\| PubMed ID: 30612202	2019
Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults. Nutrients\| PubMed ID: 30654453	2019
The historical context and scientific legacy of John O. Holloszy. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 30730811	2019
Medical marijuana-an obesity problem or opportunity? International journal of obesity (2005)\| PubMed ID: 30755697	2019
A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes. Molecular nutrition & food research\| PubMed ID: 30763457	2019
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats. Obesity surgery\| PubMed ID: 30809769	2019
Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 30860878	2019
Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training. Physiological reports\| PubMed ID: 30912283	2019
Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial. The Journal of clinical endocrinology and metabolism\| PubMed ID: 31322672	2019
Non-invasive assessment of hepatic lipid subspecies matched with non-alcoholic fatty liver disease phenotype. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 31371265	2019
UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans. Physiological reports\| PubMed ID: 31758610	2019
Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD. Medicine and science in sports and exercise\| PubMed ID: 32028458	2020
A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study. Trials\| PubMed ID: 32051025	2020
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study. The European respiratory journal\| PubMed ID: 32108049	2020
Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension. Pulmonary circulation\| PubMed ID: 32110382	2020
Joint international consensus statement for ending stigma of obesity. Nature medicine\| PubMed ID: 32127716	2020
Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial. Contemporary clinical trials\| PubMed ID: 32389808	2020
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 32396388	2020
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes\| PubMed ID: 32409493	2020
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes. Medicine and science in sports and exercise\| PubMed ID: 32496736	2020
Effects of gastric bypass surgery on expression of glucose transporters and fibrotic biomarkers in kidney of diabetic fatty rats. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery\| PubMed ID: 32505735	2020
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO molecular medicine\| PubMed ID: 32519812	2020
Exercise plus caloric restriction lowers soluble RAGE in adults with chronic kidney disease. Obesity science & practice\| PubMed ID: 32523720	2020
Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes. Surgical endoscopy\| PubMed ID: 32607903	2021
Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki). Frontiers in physiology\| PubMed ID: 32612543	2020
Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link? International journal of obesity (2005)\| PubMed ID: 32647360	2020
Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 32798563	2021
Outpatient Screening of Health Status Among Postbariatric Patients during the COVID-19 Pandemic in Sao Paulo, Brazil. Obesity (Silver Spring, Md.)\| PubMed ID: 32881292	2020
Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function. Obesity surgery\| PubMed ID: 33111247	2021
Sleep Extension: A Potential Target for Obesity Treatment. Current diabetes reports\| PubMed ID: 33275183	2020
Roux-en-Y Gastric Bypass Restores Islet Function and Morphology Independent of Body Weight in ZDF Rats. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 33427046	2021
Resting Energy Expenditure Is Elevated in Asthma. Nutrients\| PubMed ID: 33805960	2021
Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults with Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 33870426	2021
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans. Metabolism: clinical and experimental\| PubMed ID: 34090870	2021
Exercise Is Key to Sustaining Metabolic Gains After Bariatric Surgery. Exercise and sport sciences reviews\| PubMed ID: 34112745	2021
Patient Reported Outcomes after Metabolic Surgery Versus Medical Therapy for Diabetes: Insights from the STAMPEDE Randomized Trial. Annals of surgery\| PubMed ID: 34132694	2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Disease models & mechanisms\| PubMed ID: 34160014	2021
Constraints of Weight Loss as a Marker of Bariatric Surgery Success: An Exploratory Study. Frontiers in physiology\| PubMed ID: 34177607	2021
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Disease models & mechanisms\| PubMed ID: 34296742	2021