Janis Kuka

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis

Affiliated withLatvian Institute of Organic Synthesis Latvian Institute of Organic Synthesis

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart. Life sciences\| PubMed ID: 18801379	2008
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. Cardiovascular drugs and therapy\| PubMed ID: 19536647	2009
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. British journal of pharmacology\| PubMed ID: 19594753	2009
Effects of long-term mildronate treatment on cardiac and liver functions in rats. Basic & clinical pharmacology & toxicology\| PubMed ID: 19663820	2009
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 19912061	2009
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers. The Journal of pharmacy and pharmacology\| PubMed ID: 21827492	2011
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats. Pharmacological reports : PR\| PubMed ID: 21857086	2011
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. Journal of cardiovascular pharmacology and therapeutics\| PubMed ID: 21903968	2012
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. Cardiovascular toxicology\| PubMed ID: 22539084	2012
Troubleshooting digital macro photography for image acquisition and the analysis of biological samples. Journal of pharmacological and toxicological methods\| PubMed ID: 23202591	2013
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 23525500	2013
The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism: clinical and experimental\| PubMed ID: 24140100	2014
Magnesium nitrate attenuates blood pressure rise in SHR rats. Magnesium research\| PubMed ID: 24827813	2014
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size. Pharmacological research\| PubMed ID: 24836867	2014
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria. Molecular and cellular biochemistry\| PubMed ID: 24878991	2014
Expression and purification of active, stabilized trimethyllysine hydroxylase. Protein expression and purification\| PubMed ID: 25220864	2014
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation. Life sciences\| PubMed ID: 25301199	2014
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis. Vascular pharmacology\| PubMed ID: 25989106	2015
Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae. The Journal of biological chemistry\| PubMed ID: 26187464	2015
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. Pharmacological research\| PubMed ID: 26621248	2016
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacological research\| PubMed ID: 26850121	2016
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. The Biochemical journal\| PubMed ID: 26936967	2016
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB. Basic & clinical pharmacology & toxicology\| PubMed ID: 28244203	2017
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice. BioFactors (Oxford, England)\| PubMed ID: 28759135	2017
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues. Scientific reports\| PubMed ID: 29235526	2017
Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice. Journal of neurotrauma\| PubMed ID: 31441378	2020
Excretion of the Polymyxin Derivative NAB739 in Murine Urine. Antibiotics (Basel, Switzerland)\| PubMed ID: 32230751	2020
Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload. Cardiovascular drugs and therapy\| PubMed ID: 32424653	2020
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice. Scientific reports\| PubMed ID: 32884086	2020
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia. Journal of cellular and molecular medicine\| PubMed ID: 32896106	2020
-Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs. ACS medicinal chemistry letters\| PubMed ID: 33214822	2020
Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats. Oxidative medicine and cellular longevity\| PubMed ID: 34367467	2021
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free radical biology & medicine\| PubMed ID: 34728372	2021
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine\| PubMed ID: 34740109	2021
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature chemistry\| PubMed ID: 34903857	2022