Reinis Vilskersts

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis

Affiliated withLatvian Institute of Organic Synthesis Latvian Institute of Organic Synthesis

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis. Vascular pharmacology\| PubMed ID: 25989106	2015
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. Journal of cardiovascular pharmacology\| PubMed ID: 17204911	2006
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart. Life sciences\| PubMed ID: 18801379	2008
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. Cardiovascular drugs and therapy\| PubMed ID: 19536647	2009
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. British journal of pharmacology\| PubMed ID: 19594753	2009
Effects of long-term mildronate treatment on cardiac and liver functions in rats. Basic & clinical pharmacology & toxicology\| PubMed ID: 19663820	2009
The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092. International immunopharmacology\| PubMed ID: 20074673	2010
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats. Pharmacological reports : PR\| PubMed ID: 21857086	2011
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. Journal of cardiovascular pharmacology and therapeutics\| PubMed ID: 21903968	2012
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus. The journal of physiological sciences : JPS\| PubMed ID: 22893478	2012
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorganic & medicinal chemistry\| PubMed ID: 23582449	2013
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction. Clinical and experimental pharmacology & physiology\| PubMed ID: 23710938	2013
The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism: clinical and experimental\| PubMed ID: 24140100	2014
Magnesium nitrate attenuates blood pressure rise in SHR rats. Magnesium research\| PubMed ID: 24827813	2014
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size. Pharmacological research\| PubMed ID: 24836867	2014
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacological research\| PubMed ID: 26850121	2016
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. The Biochemical journal\| PubMed ID: 26936967	2016
Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicology letters\| PubMed ID: 28049038	2017
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice. BioFactors (Oxford, England)\| PubMed ID: 28759135	2017
Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research. Current medicinal chemistry\| PubMed ID: 29848269	2020
Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia. Shock (Augusta, Ga.)\| PubMed ID: 30640252	2019
Sulfonyl Group Dance: A Tool for the Synthesis of 6-Azido-2-sulfonylpurine Derivatives. The Journal of organic chemistry\| PubMed ID: 32150410	2020
4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action. Oxidative medicine and cellular longevity\| PubMed ID: 32308799	2020
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia. Journal of cellular and molecular medicine\| PubMed ID: 32896106	2020
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury. Physiological reports\| PubMed ID: 33207081	2020
Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure. Frontiers in cell and developmental biology\| PubMed ID: 33520996	2020
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free radical biology & medicine\| PubMed ID: 34728372	2021
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. International journal of molecular sciences\| PubMed ID: 35008470	2021