Maija Dambrova

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis

Affiliated withLatvian Institute of Organic Synthesis Latvian Institute of Organic Synthesis

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
Cardioprotective effects of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats. British journal of pharmacology\| PubMed ID: 10556947	1999
Mildronate: cardioprotective action through carnitine-lowering effect. Trends in cardiovascular medicine\| PubMed ID: 12242052	2002
The methylester of gamma-butyrobetaine, but not gamma-butyrobetaine itself, induces muscarinic receptor-dependent vasodilatation. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 15060760	2004
Investigations on the pharmacology of the cardioprotective guanidine ME10092. Journal of cardiovascular pharmacology\| PubMed ID: 15243298	2004
The differential influences of melanocortins on nociception in the formalin and tail flick tests. Pharmacology, biochemistry, and behavior\| PubMed ID: 16970983	2006
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. Journal of cardiovascular pharmacology\| PubMed ID: 17204911	2006
Comparative pharmacological activity of optical isomers of phenibut. European journal of pharmacology\| PubMed ID: 18275958	2008
Effect of inhibiting carnitine biosynthesis on male rat sexual performance. Physiology & behavior\| PubMed ID: 18640137	2008
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart. Life sciences\| PubMed ID: 18801379	2008
Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC\| PubMed ID: 19034959	2008
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. Cardiovascular drugs and therapy\| PubMed ID: 19536647	2009
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. British journal of pharmacology\| PubMed ID: 19594753	2009
Effects of long-term mildronate treatment on cardiac and liver functions in rats. Basic & clinical pharmacology & toxicology\| PubMed ID: 19663820	2009
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 19912061	2009
The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092. International immunopharmacology\| PubMed ID: 20074673	2010
Mildronate exerts acute anticonvulsant and antihypnotic effects. Behavioural pharmacology\| PubMed ID: 20661137	2010
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes. Cell biochemistry and function\| PubMed ID: 21370249	2011
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. European journal of pharmacology\| PubMed ID: 21371472	2011
Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats. Behavioural brain research\| PubMed ID: 21420440	2011
Investigation into stereoselective pharmacological activity of phenotropil. Basic & clinical pharmacology & toxicology\| PubMed ID: 21689376	2011
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers. The Journal of pharmacy and pharmacology\| PubMed ID: 21827492	2011
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats. Pharmacological reports : PR\| PubMed ID: 21857086	2011
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. Journal of cardiovascular pharmacology and therapeutics\| PubMed ID: 21903968	2012
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. Cardiovascular toxicology\| PubMed ID: 22539084	2012
The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery. Journal of neuroscience methods\| PubMed ID: 22640751	2012
High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients. Nutrition research (New York, N.Y.)\| PubMed ID: 22652370	2012
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus. The journal of physiological sciences : JPS\| PubMed ID: 22893478	2012
Troubleshooting digital macro photography for image acquisition and the analysis of biological samples. Journal of pharmacological and toxicological methods\| PubMed ID: 23202591	2013
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients. Journal of diabetes and its complications\| PubMed ID: 23351995	2013
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 23525500	2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorganic & medicinal chemistry\| PubMed ID: 23582449	2013
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction. Clinical and experimental pharmacology & physiology\| PubMed ID: 23710938	2013
Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis. Journal of clinical pharmacology\| PubMed ID: 23893520	2013
The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism: clinical and experimental\| PubMed ID: 24140100	2014
Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation. European journal of pharmacology\| PubMed ID: 24333219	2014
Libiguins A and B: novel phragmalin limonoids isolated from Neobeguea mahafalensis causing profound enhancement of sexual activity. Planta medica\| PubMed ID: 24549927	2014
Magnesium nitrate attenuates blood pressure rise in SHR rats. Magnesium research\| PubMed ID: 24827813	2014
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size. Pharmacological research\| PubMed ID: 24836867	2014
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria. Molecular and cellular biochemistry\| PubMed ID: 24878991	2014
Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study. Journal of the science of food and agriculture\| PubMed ID: 24917557	2015
A cross-sectional survey of urinary iodine status in Latvia. Medicina (Kaunas, Lithuania)\| PubMed ID: 25172607	2014
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation. Life sciences\| PubMed ID: 25301199	2014
Determination of trimethylamine-N-oxide in combination with L-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS. Biomedical chromatography : BMC\| PubMed ID: 25873316	2015
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis. Vascular pharmacology\| PubMed ID: 25989106	2015
Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae. The Journal of biological chemistry\| PubMed ID: 26187464	2015
R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects. Pharmacology, biochemistry, and behavior\| PubMed ID: 26234470	2015
The neuroprotective effects of R-phenibut after focal cerebral ischemia. Pharmacological research\| PubMed ID: 26621244	2016
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. Pharmacological research\| PubMed ID: 26621248	2016
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacological research\| PubMed ID: 26850121	2016
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. The Biochemical journal\| PubMed ID: 26936967	2016
The unusual pharmacokinetics of meldonium: Implications for doping. Pharmacological research\| PubMed ID: 27262679	2016
Response to comment by Sergei V. Jargin: "Meldonium (Mildronate): primum nоn nocere". Pharmacological research\| PubMed ID: 27725311	2016
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport. Basic & clinical pharmacology & toxicology\| PubMed ID: 27983775	2017
Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicology letters\| PubMed ID: 28049038	2017
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB. Basic & clinical pharmacology & toxicology\| PubMed ID: 28244203	2017
The activity of selective sigma-1 receptor ligands in seizure models in vivo. Behavioural brain research\| PubMed ID: 28389336	2017
S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity. Pharmacology, biochemistry, and behavior\| PubMed ID: 28743458	2017
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice. BioFactors (Oxford, England)\| PubMed ID: 28759135	2017
Denosumab-induced hypophosphataemia in a case of normocalcaemic primary hyperparathyroidism. Internal medicine journal\| PubMed ID: 28782221	2017
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues. Scientific reports\| PubMed ID: 29235526	2017
Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris". The Journal of clinical endocrinology and metabolism\| PubMed ID: 30124877	2018
Efficacy of Proanthocyanidins from Root Extract in Reducing Viability While Preserving Oral Commensal . Materials (Basel, Switzerland)\| PubMed ID: 30135370	2018
Development of local strontium ranelate delivery systems and long term in vitro drug release studies in osteogenic medium. Scientific reports\| PubMed ID: 30425295	2018
Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia. Shock (Augusta, Ga.)\| PubMed ID: 30640252	2019
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism. Nutrients\| PubMed ID: 30857217	2019
Allosteric Modulators of Sigma-1 Receptor: A Review. Frontiers in pharmacology\| PubMed ID: 30941035	2019
Total synthesis and evaluation of 8-deoxypumiliotoxin 193H. Natural product research\| PubMed ID: 31264906	2021
Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration. Behavioural brain research\| PubMed ID: 31276703	2019
Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice. Journal of neurotrauma\| PubMed ID: 31441378	2020
Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. Journal of molecular and cellular cardiology\| PubMed ID: 31445917	2019
Pharmacological approaches to tackle NCLs. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 31521819	2020
Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry. Data in brief\| PubMed ID: 31692721	2019
Medicinal plants and their uses recorded in the Archives of Latvian Folklore from the 19th century. Journal of ethnopharmacology\| PubMed ID: 31707047	2020
Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from DC Root Extract. Nutrients\| PubMed ID: 31752295	2019
Altered mitochondrial metabolism in the insulin-resistant heart. Acta physiologica (Oxford, England)\| PubMed ID: 31840389	2020
Data on medicinal plants in the records of Latvian folk medicine from the 19th century. Data in brief\| PubMed ID: 31909122	2020
Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity. Frontiers in endocrinology\| PubMed ID: 31920980	2019
Excretion of the Polymyxin Derivative NAB739 in Murine Urine. Antibiotics (Basel, Switzerland)\| PubMed ID: 32230751	2020
Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology\| PubMed ID: 32279140	2020
Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports. Pharmacopsychiatry\| PubMed ID: 32340063	2020
Cardiac metabolism as a driver and therapeutic target of myocardial infarction. Journal of cellular and molecular medicine\| PubMed ID: 32384583	2020
Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload. Cardiovascular drugs and therapy\| PubMed ID: 32424653	2020
Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiological reports\| PubMed ID: 32562386	2020
Inhibition of sigma-1 receptors substantially modulates GABA and glutamate transport in presynaptic nerve terminals. Experimental neurology\| PubMed ID: 32795464	2020
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice. Scientific reports\| PubMed ID: 32884086	2020
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia. Journal of cellular and molecular medicine\| PubMed ID: 32896106	2020
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury. Physiological reports\| PubMed ID: 33207081	2020
Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury. Oxidative medicine and cellular longevity\| PubMed ID: 33274011	2020
Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Scientific reports\| PubMed ID: 33299068	2020
Chemical composition of Prunus padus L. flower extract and its anti-inflammatory activities in primary bone marrow-derived macrophages. Journal of ethnopharmacology\| PubMed ID: 33307057	2021
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures. Neurobiology of disease\| PubMed ID: 33385516	2021
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury. Free radical biology & medicine\| PubMed ID: 33484825	2021
Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure. Frontiers in cell and developmental biology\| PubMed ID: 33520996	2020
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism. International journal of molecular sciences\| PubMed ID: 34208786	2021
Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats. Oxidative medicine and cellular longevity\| PubMed ID: 34367467	2021
The Cultivation of L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants. Plants (Basel, Switzerland)\| PubMed ID: 34579502	2021
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free radical biology & medicine\| PubMed ID: 34728372	2021
Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury. International journal of molecular sciences\| PubMed ID: 34769042	2021
Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia. Medicina (Kaunas, Lithuania)\| PubMed ID: 34833429	2021
HMDB 5.0: the Human Metabolome Database for 2022. Nucleic acids research\| PubMed ID: 34986597	2022
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. International journal of molecular sciences\| PubMed ID: 35008470	2021