a-simplified-model-for-heterotopic-heart-valve-transplantation

A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents

There is an urgent clinical need for heart valve replacements that can grow in children. Heart valve transplantation is proposed as a new type of ...

Medical University of South Carolina

Extracardiac Fontan Operation: How I Teach It.

Children undergoing congenital cardiac surgery often outgrow the valve implants. These children are thus committed to morbid reoperations for successive exchanges of the vavular implants that they have outgrown. Therefore the holy grail of congenital cardiac surgery is a valve implant that grows with the recipient child. Preserved homografts routinely are used as valve implants, but they do not grow as the child grows because they lose viability during preservation. In contrast, pulmonary autografts and pediatric heart transplants grow with the recipient children. Similarly, partial heart transplantation can deliver growing valve implants for congenital cardiac surgery. Temporary immune suppression would only be needed until the partial heart transplant can be exchanged for an adult-sized prosthetic valve in the grown child.

Evidence-based surgical hypothesis: Partial heart transplantation can deliver growing valve implants for congenital cardiac surgery.

Norwood palliation for hypoplastic left heart syndrome typically results in retrograde perfusion of the native aortic root. This may predispose to native aortic root thrombosis (NART).

Native Aortic Root Thrombosis After Norwood Palliation for Hypoplastic Left Heart Syndrome.

The Ross operation is the preferred treatment for aortic valve replacement in children. However previous studies indicate that outcomes in neonates are poor. This meta-analysis examines the pooled outcomes of the Ross operation in neonates.

Article	Year
Extracardiac Fontan Operation: How I Teach It. The Annals of thoracic surgery\| PubMed ID: 32693037	2020
Evidence-based surgical hypothesis: Partial heart transplantation can deliver growing valve implants for congenital cardiac surgery. Surgery\| PubMed ID: 32948337	2021
Native Aortic Root Thrombosis After Norwood Palliation for Hypoplastic Left Heart Syndrome. The Annals of thoracic surgery\| PubMed ID: 32987016	2021
Ross Operation in Neonates: A Meta-analysis. The Annals of thoracic surgery\| PubMed ID: 33275929	2020
Aortic Valve Replacement in Neonates: An Unsolved Problem with Limited Quality of Evidence. The Annals of thoracic surgery\| PubMed ID: 33839126	2021

Taufiek K. Rajab

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