Jeannie Chen

Zilkha Neurogenetic Institute, University of Southern California

Affiliated withUniversity of Southern California

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2021

Other Publications

Article	Year
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10097103	1999
Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10704489	2000
Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11493703	2001
The carboxyl-terminal domain is essential for rhodopsin transport in rod photoreceptors. Vision research\| PubMed ID: 11853757	2002
Mouse models to study GCAP functions in intact photoreceptors. Advances in experimental medicine and biology\| PubMed ID: 12596933	2002
Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling. The Journal of biological chemistry\| PubMed ID: 12815044	2003
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15155902	2004
Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron\| PubMed ID: 15944125	2005
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. The Journal of clinical investigation\| PubMed ID: 16453022	2006
Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17108167	2006
Molecular properties of rhodopsin and rod function. The Journal of biological chemistry\| PubMed ID: 17194706	2007
Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice. Investigative ophthalmology & visual science\| PubMed ID: 17460248	2007
Investigation of alpha-synuclein fibril structure by site-directed spin labeling. The Journal of biological chemistry\| PubMed ID: 17573347	2007
Signaling properties of a short-wave cone visual pigment and its role in phototransduction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17881515	2007
Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Molecular neurodegeneration\| PubMed ID: 18939994	2008
Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19066219	2008
Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Current biology : CB\| PubMed ID: 19361994	2009
Soluble and mature amyloid fibrils in drusen deposits. Investigative ophthalmology & visual science\| PubMed ID: 19892876	2010
Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nature methods\| PubMed ID: 19966809	2010
Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: a mouse model of Q344ter-induced retinal degeneration. PloS one\| PubMed ID: 20532191	2010
Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nature protocols\| PubMed ID: 20671723	2010
Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health. Neuroscience\| PubMed ID: 21075174	2011
Channel modulation and the mechanism of light adaptation in mouse rods. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21123569	2010
Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Investigative ophthalmology & visual science\| PubMed ID: 21398289	2011
Role of guanylyl cyclase modulation in mouse cone phototransduction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21632921	2011
Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery. PloS one\| PubMed ID: 21818392	2011
Effect of the ILE86TER mutation in the Î³ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Cellular signalling\| PubMed ID: 21920434	2012
Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22566632	2012
Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity. The Journal of biological chemistry\| PubMed ID: 23288843	2013
Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23690606	2013
Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant. Cellular signalling\| PubMed ID: 24012956	2013
The physiological roles of arrestin-1 in rod photoreceptor cells. Handbook of experimental pharmacology\| PubMed ID: 24292825	2014
Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity. PLoS genetics\| PubMed ID: 25058152	2014
Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells. The Journal of biological chemistry\| PubMed ID: 25183010	2014
Regulation of Mammalian cone phototransduction by recoverin and rhodopsin kinase. The Journal of biological chemistry\| PubMed ID: 25673692	2015
C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. eLife\| PubMed ID: 25910054	2015
A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Human molecular genetics\| PubMed ID: 26246500	2015
Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27358455	2016
The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction. Scientific reports\| PubMed ID: 27580676	2016
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Scientific reports\| PubMed ID: 28145503	2017
The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators. ACS chemical biology\| PubMed ID: 28195691	2017
Two pathways of rod photoreceptor cell death induced by elevated cGMP. Human molecular genetics\| PubMed ID: 28379353	2017
Separation of photoreceptor cell compartments in mouse retina for protein analysis. Molecular neurodegeneration\| PubMed ID: 28399904	2017
The Na/Ca, K exchanger NCKX4 is required for efficient cone-mediated vision. eLife\| PubMed ID: 28650316	2017
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Experimental eye research\| PubMed ID: 29122605	2018
Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. The Journal of biological chemistry\| PubMed ID: 29549122	2018
Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Progress in retinal and eye research\| PubMed ID: 29883715	2018
Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1. Frontiers in molecular neuroscience\| PubMed ID: 29973866	2018
The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx. The Journal of biological chemistry\| PubMed ID: 30126843	2018
Elementary response triggered by transducin in retinal rods. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30796193	2019
Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31285302	2019
Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling. Investigative ophthalmology & visual science\| PubMed ID: 32315379	2020
Dark noise and retinal degeneration from D190N-rhodopsin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32873651	2020
Biological Role of Arrestin-1 Oligomerization. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 32948676	2020
Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina. Bio-protocol\| PubMed ID: 33654813	2019
Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted. Nature communications\| PubMed ID: 34257293	2021