Nicholas O. Fischer

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory

Affiliated withLawrence Livermore National Laboratory Lawrence Livermore National Laboratory

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2022

Other Publications

Article	Year
Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms. The Analyst\| PubMed ID: 17325749	2007
Aptasensors for biosecurity applications. Current opinion in chemical biology\| PubMed ID: 17548236	2007
Protein detection via direct enzymatic amplification of short DNA aptamers. Analytical biochemistry\| PubMed ID: 17980857	2008
Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin. Chemical communications (Cambridge, England)\| PubMed ID: 18401506	2008
Massively parallel interrogation of aptamer sequence, structure and function. PloS one\| PubMed ID: 18628955	2008
Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification. Bioorganic & medicinal chemistry letters\| PubMed ID: 18694640	2008
Biofunctional subwavelength optical waveguides for biodetection. ACS nano\| PubMed ID: 19206625	2008
Immobilization of His-tagged proteins on nickel-chelating nanolipoprotein particles. Bioconjugate chemistry\| PubMed ID: 19239247	2009
Hydrogen production by a hyperthermophilic membrane-bound hydrogenase in water-soluble nanolipoprotein particles. Journal of the American Chemical Society\| PubMed ID: 19449869	2009
Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis. Bioconjugate chemistry\| PubMed ID: 20509624	2010
Kinetic analysis of his-tagged protein binding to nickel-chelating nanolipoprotein particles. Bioconjugate chemistry\| PubMed ID: 20586461	2010
Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III. PloS one\| PubMed ID: 20657844	2010
Identification and optimization of DNA aptamer binding regions using DNA microarrays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21370059	2011
Enhanced cellulose degradation using cellulase-nanosphere complexes. PloS one\| PubMed ID: 22870287	2012
Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens. Journal of the American Chemical Society\| PubMed ID: 23331082	2013
The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge. Biomaterials\| PubMed ID: 24075406	2013
Quantifying interactions of a membrane protein embedded in a lipid nanodisc using fluorescence correlation spectroscopy. Biophysical journal\| PubMed ID: 24461026	2014
Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform. PloS one\| PubMed ID: 24675794	2014
Enhancing the efficacy of innate immune agonists: could nanolipoprotein particles hold the key? Nanomedicine (London, England)\| PubMed ID: 24746187	2014
Nanoparticles and antigen delivery: understanding the benefits and drawbacks of different delivery platforms. Nanomedicine (London, England)\| PubMed ID: 24787434	2014
Fluorescence correlation spectroscopy at micromolar concentrations without optical nanoconfinement. The journal of physical chemistry. B\| PubMed ID: 25060197	2014
Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake. ACS applied materials & interfaces\| PubMed ID: 27411034	2016
Enhancement of antigen-specific CD4 and CD8 T cell responses using a self-assembled biologic nanolipoprotein particle vaccine. Vaccine\| PubMed ID: 28214044	2017
Cell-free production of a functional oligomeric form of a major outer-membrane protein (MOMP) for vaccine development. The Journal of biological chemistry\| PubMed ID: 28739800	2017
Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles. Protein science : a publication of the Protein Society\| PubMed ID: 29266475	2018
Lipid composition dictates serum stability of reconstituted high-density lipoproteins: implications for in vivo applications. Nanoscale\| PubMed ID: 29564446	2018
Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems. Scientific reports\| PubMed ID: 30018409	2018
Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30541879	2019
Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array. Scientific reports\| PubMed ID: 30858401	2019
Optimizing cell encapsulation condition in ECM-Collagen I hydrogels to support 3D neuronal cultures. Journal of neuroscience methods\| PubMed ID: 31626846	2020
A Reconfigurable In Vitro Model for Studying the Blood-Brain Barrier. Annals of biomedical engineering\| PubMed ID: 31741228	2020
A flexible 3-dimensional microelectrode array for in vitro brain models. Lab on a chip\| PubMed ID: 31976505	2020
Cationic HDL mimetics enhance in vivo delivery of self-replicating mRNA. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31982617	2020
HIV influences microtubule associated protein-2: potential marker of HIV-associated neurocognitive disorders. AIDS (London, England)\| PubMed ID: 32073448	2020
Modeling the temporal network dynamics of neuronal cultures. PLoS computational biology\| PubMed ID: 32453727	2020
Functional and transcriptional characterization of complex neuronal co-cultures. Scientific reports\| PubMed ID: 32620908	2020
Characterization of Spore Proteins Using a Nanoscaffold Vaccine Platform. Frontiers in immunology\| PubMed ID: 32714323	2020
Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To ... Journal of virology\| PubMed ID: 34076479	2021
Induction of Protection in Mice against a Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in Nanolipoprotein Particles. Vaccines\| PubMed ID: 34358171	2021
Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances. Current opinion in pharmacology\| PubMed ID: 34481335	2021
A Survey of Preclinical Studies Evaluating Nanoparticle-Based Vaccines Against Non-Viral Sexually Transmitted Infections. Frontiers in pharmacology\| PubMed ID: 34899322	2021