ultrasonic-assisted-extraction-cannabidiolic-acid-from-cannabis

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from <em>Cannabis</em> Biomass

Industrial hemp (Cannabis spp.) has many compounds of interest with potential medical benefits. Of these compounds, cannabinoids have come to the center ...

Chuncheon Bioindustry Foundation

 root is traditionally known to be effective in the treatment of diabetes in Korea.  root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of  (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (), CCAAT/enhancer binding protein alpha (), and sterol regulatory element binding protein1 () and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.

Sun-Yeop Lee

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