collection-expansion-differentiation-primary-human-nasal-epithelial

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Measurements of cilia function (beat frequency, pattern) have been established as diagnostic tools for respiratory diseases such as primary ciliary ...

University of New South Wales Australia

Sarcoidosis has often been termed an "immune paradox" as there is peripheral anergy to common recall antigens despite pronounced TH1-dominant inflammation at disease sites, such as the lung, with up-regulation of interferon γ, IL-27 and transcription factors. Peripheral blood may reflect the anergic state, while exhaled breath condensate (EBC) analysis may offer insights into the lung disease.

T-bet and interleukin-27: possible TH1 immunomodulators of sarcoidosis.

Although blended learning has the potential to enhance the student experience, both in terms of engagement and flexibility, it can be difficult to effectively restructure existing courses. To achieve these goals for an introductory Pathology course, offered to more than 250 undergraduate students at UNSW Sydney, we devised a novel approach.

A model for the use of blended learning in large group teaching sessions.

Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the world, is a chronic inflammatory disease of the airways usually caused by long-term exposure to inhaled irritants. Airway epithelial cells (AECs) play a key role in initializing COPD and driving the exacerbation of this disease through the release of various cytokines. This AEC-derived cytokine response is tightly regulated possibly through the regulatory effects of noncoding RNAs (ncRNAs). Although the importance of ncRNAs in pulmonary diseases has been increasingly realized, little is known about the role of ncRNA in the regulation of inflammatory responses in COPD. This review outlines the features of AEC-derived cytokine responses in COPD and how ncRNAs regulate these inflammatory responses.

Article	Year
T-bet and interleukin-27: possible TH1 immunomodulators of sarcoidosis. Inflammopharmacology\| PubMed ID: 26254778	2015
A model for the use of blended learning in large group teaching sessions. BMC medical education\| PubMed ID: 29121908	2017
The role of noncoding RNAs in regulating epithelial responses in COPD. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 29722561	2018

Cristan Herbert

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