Vincent F. M. Segers

Vincent F. M. Segers

Laboratory of Physiopharmacology, University of Antwerp

Affiliated withUniversity of AntwerpUniversity Hospital Antwerp

Research Area

Biography

Vincent Segers is associate professor at the University of Antwerp and interventional cardiologist at the University Hospital Antwerp, Belgium. He graduated medical school Summa cum laude and started his Ph.D. at the laboratory of Physiology at the University of Antwerp and, thereafter, worked in Boston from 2005‒2010, first as a postdoctoral research fellow at Harvard Medical School (2005–2008)—supported by a postdoctoral fellowship of the Belgian American Educational Foundation (BAEF). At the cardiovascular laboratory of Richard Lee, Vincent worked on multiple projects including a project in which he studied myocyte renewal during normal aging and after myocardial injury using a genetic fate-mapping approach. He also invented new protease-resistant variants of Stromal cell-derived factor-1 (SDF1)—a discovery that resulted in the foundation of a start-up biotechnology company, called Provasculon, in 2008. Vincent managed the activities at Provasculon as Senior Director from 2008–2010; Provasculon was acquired by Mesoblast in 2013.

Between Oct 2010 and June 2015, he completed his cardiology training and training in interventional cardiology. In 2013, Vincent Segers was appointed assistant professor of physiology at the University of Antwerp and started to work on the NRG1/ERBB system together with Gilles De Keulenaer. They are interested in basic and translational science in the field of ventricular and atrial myopathy, and use methods ranging from molecular biology to large-animal models. The goal of their lab is to develop new therapies for common cardiovascular diseases, including heart failure.

JoVE Journal Publications

ArticleTotal : 1
Year
Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Publication title

Cited by 7

2021

Other Publications

Article
Year
Inhibition of heme oxygenase-1 impairs cardiac muscle sensitivity to beta-adrenergic stimulation.

Basic research in cardiology| PubMed ID: 15630521

2005
Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 16243916

2006
Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk.

The Journal of biological chemistry| PubMed ID: 16698793

2006
Endogenous inhibitors of hypertrophy in concentric versus eccentric hypertrophy.

European journal of heart failure| PubMed ID: 17127094

2007
2012
2013
2015
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.

American journal of physiology. Endocrinology and metabolism| PubMed ID: 26786778

2016
ErbB2 signaling at the crossing between heart failure and cancer.

Basic research in cardiology| PubMed ID: 27596216

2016
2017
Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 28822966

2017
Evidence and Indications for Percutaneous Closure of the Left Atrial Appendage.

Revista espanola de cardiologia (English ed.)| PubMed ID: 29653775

2018
2018
Cellular senescence links aging and diabetes in cardiovascular disease.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 29750567

2018
2018
Epigenetic regulation of intercellular communication in the heart.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 30951364

2019
2019
Coronary-subclavian steal syndrome, an easily overlooked entity in interventional cardiology.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions| PubMed ID: 31179616

2020
2019
2019
The role of endothelial miRNAs in myocardial biology and disease.

Journal of molecular and cellular cardiology| PubMed ID: 31756323

2020
The role of ErbB4 in cancer.

Cellular oncology (Dordrecht)| PubMed ID: 32219702

2020
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology.

Journal of pharmacological and toxicological methods| PubMed ID: 32565326

2020
The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 32618511

2020
Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets.

Journal of the American Heart Association| PubMed ID: 33470124

2021
Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 33989083

2021
2021