Justin D. Lathia

Case Western Reserve University

Affiliated withCase Western Reserve University Cleveland Clinic

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2021

Other Publications

Article	Year
Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS biology\| PubMed ID: 20186265	2010
c-Myc is required for maintenance of glioma cancer stem cells. PloS one\| PubMed ID: 19020659	2008
Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides. Cell adhesion & migration\| PubMed ID: 19458479	2009
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem cells (Dayton, Ohio)\| PubMed ID: 19658188	2009
Squelching glioblastoma stem cells by targeting REST for proteasomal degradation. Trends in neurosciences\| PubMed ID: 19748686	2009
Integrin alpha 6 regulates glioblastoma stem cells. Cell stem cell\| PubMed ID: 20452317	2010
Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance. Genes & cancer\| PubMed ID: 20657792	2010
Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology? Stem cell reviews\| PubMed ID: 20957452	2011
Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells. Glia\| PubMed ID: 21046557	2011
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer cell\| PubMed ID: 21481791	2011
Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell stem cell\| PubMed ID: 21549324	2011
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell\| PubMed ID: 21729780	2011
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PloS one\| PubMed ID: 21961046	2011
Twisted tango: brain tumor neurovascular interactions. Nature neuroscience\| PubMed ID: 22030548	2011
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. The Journal of experimental medicine\| PubMed ID: 22393126	2012
Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma. Cancer research\| PubMed ID: 22396498	2012
Holding on to stemness. Nature cell biology\| PubMed ID: 22552145	2012
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes & development\| PubMed ID: 22661233	2012
Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair. Trends in neurosciences\| PubMed ID: 22784557	2012
The malignant social network: cell-cell adhesion and communication in cancer stem cells. Cell adhesion & migration\| PubMed ID: 22796941	2012
Laminin alpha 2 enables glioblastoma stem cell growth. Annals of neurology\| PubMed ID: 23280793	2012
Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines. PloS one\| PubMed ID: 23308131	2013
Growth factor receptors define cancer hierarchies. Cancer cell\| PubMed ID: 23410969	2013
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell\| PubMed ID: 23540695	2013
Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy. PloS one\| PubMed ID: 23936469	2013
Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma. PloS one\| PubMed ID: 23951053	2013
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nature neuroscience\| PubMed ID: 23995067	2013
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocrine-related cancer\| PubMed ID: 24025407	2013
The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Experimental eye research\| PubMed ID: 24246263	2014
miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24368849	2014
High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. Cell reports\| PubMed ID: 24373972	2014
Decoding the cancer stem cell hypothesis in glioblastoma. CNS oncology\| PubMed ID: 24379973	2013
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene\| PubMed ID: 24488013	2015
Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. Stem cells (Dayton, Ohio)\| PubMed ID: 24737733	2014
Modeling mayhem: predicting invasion and proliferation kinetics in IDH1 mutant glioblastoma with mathematical models. Neuro-oncology\| PubMed ID: 24739516	2014
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nature cell biology\| PubMed ID: 24747440	2014
Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24895995	2014
Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells. Glia\| PubMed ID: 24909307	2014
Cancer stem cells: moving past the controversy. CNS oncology\| PubMed ID: 25054813	2013
Development of a Sox2 reporter system modeling cellular heterogeneity in glioma. Neuro-oncology\| PubMed ID: 25416826	2015
High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues. Nature photonics\| PubMed ID: 25621002	2014
Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer. Stem cells (Dayton, Ohio)\| PubMed ID: 25827713	2015
Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Science signaling\| PubMed ID: 25943352	2015
Differential connexin function enhances self-renewal in glioblastoma. Cell reports\| PubMed ID: 25959821	2015
Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration. Oncotarget\| PubMed ID: 25960544	2015
Cancer stem cells in glioblastoma. Genes & development\| PubMed ID: 26109046	2015
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation. Neuro-oncology\| PubMed ID: 26136493	2016
The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities. Neuro-oncology\| PubMed ID: 26264894	2016
Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling. Neuro-oncology\| PubMed ID: 26374689	2016
Cx25 contributes to leukemia cell communication and chemosensitivity. Oncotarget\| PubMed ID: 26375552	2015
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. Cancer cell\| PubMed ID: 26461092	2015
Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models. Cancer research\| PubMed ID: 26921329	2016
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury. Journal of neurotrauma\| PubMed ID: 26976047	2017
Cisplatin induces stemness in ovarian cancer. Oncotarget\| PubMed ID: 27105520	2016
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion. Stem cells (Dayton, Ohio)\| PubMed ID: 27145382	2016
Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells. Trends in neurosciences\| PubMed ID: 27155992	2016
Reporter Systems to Study Cancer Stem Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27221339	2016
Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells. Oncotarget\| PubMed ID: 27270311	2016
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation. Cell reports\| PubMed ID: 27396333	2016
Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting. Journal of neuro-oncology\| PubMed ID: 27510953	2016
Adhering towards tumorigenicity: altered adhesion mechanisms in glioblastoma cancer stem cells. CNS oncology\| PubMed ID: 27616054	2016
Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells. Cell death and differentiation\| PubMed ID: 27740621	2017
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression. Cell stem cell\| PubMed ID: 28089910	2017
Isolation, Characterization, and Expansion of Cancer Stem Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28229412	2017
Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 28374184	2017
Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma. Oncotarget\| PubMed ID: 28410193	2017
An update on minding the gap in cancer. Biochimica et biophysica acta\| PubMed ID: 28655619	2018
Overview of Cancer Stem Cells and Stemness for Community Oncologists. Targeted oncology\| PubMed ID: 28664387	2017
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. Stem cell reports\| PubMed ID: 28689994	2017
STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance. Endocrine-related cancer\| PubMed ID: 28729467	2017
Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value. PloS one\| PubMed ID: 28837569	2017
CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors. The Journal of experimental medicine\| PubMed ID: 28838952	2017
Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28912141	2017
New Advances and Challenges of Targeting Cancer Stem Cells. Cancer research\| PubMed ID: 28928129	2017
A 4-miRNA signature to predict survival in glioblastomas. PloS one\| PubMed ID: 29136645	2017
Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells. Stem cell reports\| PubMed ID: 29198824	2017
Revealing the glioma cancer stem cell interactome, one niche at a time. The Journal of pathology\| PubMed ID: 29282720	2018
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nature communications\| PubMed ID: 29422613	2018
Females have the survival advantage in glioblastoma. Neuro-oncology\| PubMed ID: 29474647	2018
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Tra... Journal of neurochemistry\| PubMed ID: 29644711	2018
Therapeutic Injury and Tumor Regrowth: Tumor Resection and Radiation Establish the Recurrent Glioblastoma Microenvironment. EBioMedicine\| PubMed ID: 29699876	2018
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. Scientific reports\| PubMed ID: 29743610	2018
An anatomic transcriptional atlas of human glioblastoma. Science (New York, N.Y.)\| PubMed ID: 29748285	2018
Five-Part Pentameric Nanocomplex Shows Improved Efficacy of Doxorubicin in CD44+ Cancer Cells. ACS omega\| PubMed ID: 30023561	2017
Comparing and Contrasting the Effects of Condensin II Subunit dCAP-D3 Overexpression and Depletion . Genetics\| PubMed ID: 30068527	2018
Sex-specific gene and pathway modeling of inherited glioma risk. Neuro-oncology\| PubMed ID: 30124908	2019
Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models. Cancer discovery\| PubMed ID: 30361447	2019
Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI insight\| PubMed ID: 30385717	2018
Targeting Cancer Stemness in the Clinic: From Hype to Hope. Cell stem cell\| PubMed ID: 30595497	2019
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Science translational medicine\| PubMed ID: 30602536	2019
High-Throughput Automated Single-Cell Imaging Analysis Reveals Dynamics of Glioblastoma Stem Cell Population During State Transition. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 30729665	2019
Drak, Drak, Goose: A New Signaling Axis in Glioblastoma. Cancer research\| PubMed ID: 30877099	2019
Development of a Cx46 Targeting Strategy for Cancer Stem Cells. Cell reports\| PubMed ID: 31018124	2019
IL-11 drives postsurgical hepatocellular carcinoma recurrence. EBioMedicine\| PubMed ID: 31402232	2019
ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells. Cancer discovery\| PubMed ID: 31434712	2019
The dystroglycan receptor maintains glioma stem cells in the vascular niche. Acta neuropathologica\| PubMed ID: 31463571	2019
Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells. JCI insight\| PubMed ID: 31600167	2019
Thy-1 predicts poor prognosis and is associated with self-renewal in ovarian cancer. Journal of ovarian research\| PubMed ID: 31735168	2019
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer. Scientific reports\| PubMed ID: 31776402	2019
ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & cellular oncology\| PubMed ID: 31993498	2020
Optimising gene editing for cancer therapy. Nature cell biology\| PubMed ID: 32086445	2020
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells. Cell death & disease\| PubMed ID: 32102991	2020
FGF2: a novel druggable target for glioblastoma? Expert opinion on therapeutic targets\| PubMed ID: 32174197	2020
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma. Molecular metabolism\| PubMed ID: 32180553	2020
Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner. Cancer discovery\| PubMed ID: 32300059	2020
Sex Differences in Cancer Incidence and Survival: A Pan-Cancer Analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 32349967	2020
Release the ballast: Glioblastoma rises above radiation therapy by exporting miR-603 in extracellular vesicles to become treatment-resistant. EBioMedicine\| PubMed ID: 32502962	2020
JAM-A functions as a female microglial tumor suppressor in glioblastoma. Neuro-oncology\| PubMed ID: 32592484	2020
Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression. Frontiers in immunology\| PubMed ID: 32625208	2020
Sexually dimorphic impact of the iron-regulating gene, , on survival in glioblastoma. Neuro-oncology advances\| PubMed ID: 32642673	2020
Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression. Cancer research\| PubMed ID: 32816855	2020
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO molecular medicine\| PubMed ID: 33124191	2020
Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles. Scientific reports\| PubMed ID: 33139767	2020
The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions. Neuro-oncology\| PubMed ID: 33173943	2021
High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33237547	2021
Connexins in Cancer: Jekyll or Hyde? Biomolecules\| PubMed ID: 33321749	2020
Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells. JCI insight\| PubMed ID: 33351787	2021
Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma. Journal of medicinal chemistry\| PubMed ID: 33523674	2021
Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 33542075	2021
Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nature genetics\| PubMed ID: 33558758	2021
Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors. Seminars in cancer biology\| PubMed ID: 33640445	2021
A circuitous route to GBM stem cell signalling. Nature cell biology\| PubMed ID: 33664497	2021
Go, cancer stem cell, go! CSCs overcome myelin inhibition to move within white matter pathways. Brain : a journal of neurology\| PubMed ID: 33693693	2021
Fountain of chaos: cerebrospinal fluid enhancement of cancer stem cells in glioblastoma. Neuro-oncology\| PubMed ID: 33749775	2021
Sex Differences in Glioblastoma Immunotherapy Response. Neuromolecular medicine\| PubMed ID: 33864598	2021
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches. Acta neuropathologica communications\| PubMed ID: 34059134	2021
Cancer stem cell-immune cell crosstalk in tumour progression. Nature reviews. Cancer\| PubMed ID: 34103704	2021
Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma. The Journal of clinical investigation\| PubMed ID: 34255747	2021
Neutralizing shapeshifting pericytes enhances glioblastoma therapeutic efficacy. Cell research\| PubMed ID: 34267351	2021
Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19. Signal transduction and targeted therapy\| PubMed ID: 34330889	2021
Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM. Translational oncology\| PubMed ID: 34365219	2021
Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas. Neuro-oncology\| PubMed ID: 34387331	2021
The Translocator Protein () Genetic Polymorphism A147T Is Associated with Worse Survival in Male Glioblastoma Patients. Cancers\| PubMed ID: 34572751	2021
Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet. Molecular & cellular oncology\| PubMed ID: 34616877	2021
All damage is not created equal: unraveling the complexity of sex chromosomes and hormones in the DNA damage response. Endocrinology\| PubMed ID: 34618897	2021