Elena S. Pak

Department of Physiology, East Carolina University

Research Area

Biography

Elena Pak is a Research Specialist in the Department of Physiology, East Carolina University in Greenville, North Carolina. She received her Bachelor with honor degree and Master in Physiology from Almaty State University in Kazakhstan.

She was trained later in Melbourne University, Australia studying beta-adrenoceptor pharmacology in heart using autoradiography technique and then in Columbia University, New York studying physiological function of beta-2 adrenergic receptors in the neonatal and adult rat ventricular myocytes.

She then moved to East Carolina University in Greenville, North Carolina where she continued her research at Dr. A. Murashov’s laboratory focusing on studying of microRNAs role in transgenerational effect of diets and exercise on offspring susceptibility to neurological and metabolic disorders using genomic, proteomic approaches as well as genetically manipulated Drosophila and mouse models.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2021

Other Publications

Article	Year
Effect of 17 beta-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice. Brain research\| PubMed ID: 12646309	2003
Differential expression of endothelin receptors in regenerating spinal motor neurons in mice. Brain research. Molecular brain research\| PubMed ID: 12941473	2003
Transplantation of neuronal and glial precursors dramatically improves sensorimotor function but not cognitive function in the traumatically injured brain. Journal of neurotrauma\| PubMed ID: 15000757	2004
Estrogen increases retrograde labeling of motoneurons: evidence of a nongenomic mechanism. American journal of physiology. Cell physiology\| PubMed ID: 15044155	2004
17beta-Estradiol enhances neuronal differentiation of mouse embryonic stem cells. FEBS letters\| PubMed ID: 15225627	2004
Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury. Neuroreport\| PubMed ID: 15486493	2004
Directed differentiation of embryonic stem cells into dorsal interneurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15545303	2005
Parallel development of cardiomyocytes and neurons in embryonic stem cell culture. Biochemical and biophysical research communications\| PubMed ID: 15894285	2005
Predifferentiated embryonic stem cells prevent chronic pain behaviors and restore sensory function following spinal cord injury in mice. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 16838066	2006
RNAi pathway is functional in peripheral nerve axons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17209129	2007
Pre-differentiated embryonic stem cells promote neuronal regeneration by cross-coupling of BDNF and IL-6 signaling pathways in the host tissue. Journal of neurotrauma\| PubMed ID: 19138107	2009
Embryonic stem cells inhibit expression of erythropoietin in the injured spinal cord. Neuroscience letters\| PubMed ID: 21056627	2011
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice. Neuroscience letters\| PubMed ID: 22172934	2012
Neurogenic potential of spinal cord organotypic culture. Neuroscience letters\| PubMed ID: 25805458	2015
Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26506979	2016
NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats. Neurourology and urodynamics\| PubMed ID: 28984997	2018
Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries. The journal of sexual medicine\| PubMed ID: 29110801	2017
miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1. Frontiers in cellular neuroscience\| PubMed ID: 29643768	2018
Clarifying the Relative Impacts of Vascular and Nerve Injury That Culminate in Erectile Dysfunction in a Pilot Study Using a Rat Model of Prostate Irradiation and a Thrombopoietin Mimetic. International journal of radiation oncology, biology, physics\| PubMed ID: 30529374	2019
Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth. The journal of sexual medicine\| PubMed ID: 30621923	2019
Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourology and urodynamics\| PubMed ID: 31074529	2019
Ex Vivo Radiation Leads to Opposing Neurite Growth in Whole Ganglia vs Dissociated Cultured Pelvic Neurons. The journal of sexual medicine\| PubMed ID: 32576498	2020
Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise. FASEB bioAdvances\| PubMed ID: 33490883	2021
High-fat diet induces obesity in adult mice but fails to develop pre-penile and penile vascular dysfunction. International journal of impotence research\| PubMed ID: 33947973	2021
Impact of prostatic radiation therapy on bladder contractility and innervation. Neurourology and urodynamics\| PubMed ID: 34015163	2021
Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction. Life sciences\| PubMed ID: 34543641	2021