Luke Alphey

Oxitec Ltd

Affiliated withOxitec Ltd University of Oxford

Research Area

Biography

Luke Alphey has not added Biography.
If you are Luke Alphey and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 132	2014

Other Publications

Article	Year
Dominant lethality and insect population control. Molecular and biochemical parasitology\| PubMed ID: 12034450	2002
PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nature genetics\| PubMed ID: 12134149	2002
Re-engineering the sterile insect technique. Insect biochemistry and molecular biology\| PubMed ID: 12225915	2002
Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies a... The Biochemical journal\| PubMed ID: 12358598	2002
Malaria control with genetically manipulated insect vectors. Science (New York, N.Y.)\| PubMed ID: 12364786	2002
Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila. EMBO reports\| PubMed ID: 12524522	2003
Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development. Genetics\| PubMed ID: 12750335	2003
giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Development (Cambridge, England)\| PubMed ID: 12756181	2003
Genetic control of vector populations: an imminent prospect. Tropical medicine & international health : TM & IH\| PubMed ID: 15078260	2004
Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila. Gene expression patterns : GEP\| PubMed ID: 15261830	2004
The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. Molecular biology of the cell\| PubMed ID: 15269282	2004
PP1beta9C interacts with Trithorax in Drosophila wing development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15366010	2004
A dominant lethal genetic system for autocidal control of the Mediterranean fruitfly. Nature biotechnology\| PubMed ID: 15750586	2005
Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila. Developmental biology\| PubMed ID: 16280124	2005
Germ line specific expression of a protein phosphatase Y interacting protein (PPYR1) in Drosophila. Gene expression patterns : GEP\| PubMed ID: 16530491	2006
Mosquito transgenesis: what is the fitness cost? Trends in parasitology\| PubMed ID: 16564223	2006
CG15031/PPYR1 is an intrinsically unstructured protein that interacts with protein phosphatase Y. Archives of biochemistry and biophysics\| PubMed ID: 16631104	2006
Transposon-free insertions for insect genetic engineering. Nature biotechnology\| PubMed ID: 16823373	2006
Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Journal of molecular biology\| PubMed ID: 17007873	2006
Yeast two-hybrid screens to identify Drosophila PP1-binding proteins. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17200561	2007
The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila. Genetics\| PubMed ID: 17277363	2007
Female-specific insect lethality engineered using alternative splicing. Nature biotechnology\| PubMed ID: 17322873	2007
Late-acting dominant lethal genetic systems and mosquito control. BMC biology\| PubMed ID: 17374148	2007
Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes. Genetics\| PubMed ID: 17513890	2007
Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17519336	2007
Genetic sexing through the use of Y-linked transgenes. Insect biochemistry and molecular biology\| PubMed ID: 17916503	2007
Managing insecticide resistance by mass release of engineered insects. Journal of economic entomology\| PubMed ID: 17972643	2007
Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. BMC molecular biology\| PubMed ID: 18412953	2008
Insect population suppression using engineered insects. Advances in experimental medicine and biology\| PubMed ID: 18510017	2008
Interview with Luke Alphey, Ph.D. [Interview by Vicki Glaser]. Vector borne and zoonotic diseases (Larchmont, N.Y.)\| PubMed ID: 19371156	2009
Natural and engineered mosquito immunity. Journal of biology\| PubMed ID: 19439051	2009
Combining pest control and resistance management: synergy of engineered insects with Bt crops. Journal of economic entomology\| PubMed ID: 19449654	2009
Sterile-insect methods for control of mosquito-borne diseases: an analysis. Vector borne and zoonotic diseases (Larchmont, N.Y.)\| PubMed ID: 19725763	2010
Sex separation strategies: past experience and new approaches. Malaria journal\| PubMed ID: 19917075	2009
Female-specific flightless phenotype for mosquito control. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20176967	2010
Transcriptomics and disease vector control. BMC biology\| PubMed ID: 20525113	2010
piggybac- and PhiC31-mediated genetic transformation of the Asian tiger mosquito, Aedes albopictus (Skuse). PLoS neglected tropical diseases\| PubMed ID: 20808959	2010
Use of a regulatory mechanism of sex determination in pest insect control. Journal of genetics\| PubMed ID: 20876996	2010
Modeling resistance to genetic control of insects. Journal of theoretical biology\| PubMed ID: 21075122	2011
Irritant and repellent behavioral responses of Aedes aegypti male populations developed for RIDL disease control strategies. Journal of medical entomology\| PubMed ID: 21175058	2010
Genetic elimination of dengue vector mosquitoes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21383140	2011
Why RIDL is not SIT. Trends in parasitology\| PubMed ID: 21659002	2011
Comparison of life history characteristics of the genetically modified OX513A line and a wild type strain of Aedes aegypti. PloS one\| PubMed ID: 21698096	2011
Field performance of a genetically engineered strain of pink bollworm. PloS one\| PubMed ID: 21931649	2011
A model framework to estimate impact and cost of genetics-based sterile insect methods for dengue vector control. PloS one\| PubMed ID: 21998654	2011
Cost of mating and insemination capacity of a genetically modified mosquito Aedes aegypti OX513A compared to its wild type counterpart. PloS one\| PubMed ID: 22022518	2011
Field performance of engineered male mosquitoes. Nature biotechnology\| PubMed ID: 22037376	2011
Multiplex detection and SNP genotyping in a single fluorescence channel. PloS one\| PubMed ID: 22272339	2012
Appropriate regulation of GM insects. PLoS neglected tropical diseases\| PubMed ID: 22303495	2012
DengueTools: innovative tools and strategies for the surveillance and control of dengue. Global health action\| PubMed ID: 22451836	2012
Field longevity of a fluorescent protein marker in an engineered strain of the pink bollworm, Pectinophora gossypiella (Saunders). PloS one\| PubMed ID: 22693645	2012
Mating compatibility and competitiveness of transgenic and wild type Aedes aegypti (L.) under contained semi-field conditions. Transgenic research\| PubMed ID: 22700207	2013
Control of the olive fruit fly using genetics-enhanced sterile insect technique. BMC biology\| PubMed ID: 22713628	2012
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. PLoS neglected tropical diseases\| PubMed ID: 22802980	2012
Flight performance and teneral energy reserves of two genetically-modified and one wild-type strain of the yellow fever mosquito Aedes aegypti. Vector borne and zoonotic diseases (Larchmont, N.Y.)\| PubMed ID: 22835152	2012
Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes. Nature biotechnology\| PubMed ID: 22965050	2012
Open field release of genetically engineered sterile male Aedes aegypti in Malaysia. PloS one\| PubMed ID: 22970102	2012
Engineered repressible lethality for controlling the pink bollworm, a lepidopteran pest of cotton. PloS one\| PubMed ID: 23226548	2012
Field cage studies and progressive evaluation of genetically-engineered mosquitoes. PLoS neglected tropical diseases\| PubMed ID: 23350003	2013
Polymerase chain displacement reaction. BioTechniques\| PubMed ID: 23384180	2013
The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing. PloS one\| PubMed ID: 23418412	2013
Oral ingestion of transgenic RIDL Ae. aegypti larvae has no negative effect on two predator Toxorhynchites species. PloS one\| PubMed ID: 23527029	2013
Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23569267	2013
Development of a population suppression strain of the human malaria vector mosquito, Anopheles stephensi. Malaria journal\| PubMed ID: 23622561	2013
Fitness of transgenic mosquito Aedes aegypti males carrying a dominant lethal genetic system. PloS one\| PubMed ID: 23690948	2013
Engineered female-specific lethality for control of pest Lepidoptera. ACS synthetic biology\| PubMed ID: 23802263	2013
Genetic control of Aedes mosquitoes. Pathogens and global health\| PubMed ID: 23816508	2013
DsRed2 transient expression in Culex quinquefasciatus mosquitoes. Memórias do Instituto Oswaldo Cruz\| PubMed ID: 23828005	2013
Genetic Control of Mosquitoes. Annual review of entomology\| PubMed ID: 24160434	2013
PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. PLoS genetics\| PubMed ID: 24204300	2013