Colin G. Nichols

Department of Cell Biology and Physiology and Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis

Affiliated withWashington University in St. Louis Washington University in St. Louis

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
beta-cell hyperexcitability: from hyperinsulinism to diabetes. Diabetes, obesity & metabolism\| PubMed ID: 17919182	2007
Dual-mode phospholipid regulation of human inward rectifying potassium channels. Biophysical journal\| PubMed ID: 21281576	2011
The diabetic β-cell: hyperstimulated vs. hyperexcited. Diabetes, obesity & metabolism\| PubMed ID: 22928573	2012
KATP channels and cardiovascular disease: suddenly a syndrome. Circulation research\| PubMed ID: 23538276	2013
Energetics and location of phosphoinositide binding in human Kir2.1 channels. The Journal of biological chemistry\| PubMed ID: 23564459	2013
Modeling K,ATP--dependent excitability in pancreatic islets. Biophysical journal\| PubMed ID: 25418087	2014
Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome. Heart rhythm\| PubMed ID: 26142302	2015
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes. Diabetes\| PubMed ID: 26246406	2015
Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel. The Journal of general physiology\| PubMed ID: 26621776	2015
K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27247394	2016
Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Cardiac electrophysiology clinics\| PubMed ID: 27261824	2016
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. The Journal of general physiology\| PubMed ID: 27527100	2016
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Royal Society open science\| PubMed ID: 28386438	2017
Control of Kir channel gating by cytoplasmic domain interface interactions. The Journal of general physiology\| PubMed ID: 28389584	2017
Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating. The Journal of biological chemistry\| PubMed ID: 28446610	2017
Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circulation research\| PubMed ID: 28674041	2017
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. The Journal of biological chemistry\| PubMed ID: 28842488	2017
Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29058191	2018
Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K channel gain-of-function by differential mechanisms. The Journal of biological chemistry\| PubMed ID: 29275331	2018
Contribution of systemic inflammation to permanence of K-induced neonatal diabetes in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 30226997	2018
Polyamines and potassium channels: A 25-year romance. The Journal of biological chemistry\| PubMed ID: 30333230	2018
Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension. Circulation. Genomic and precision medicine\| PubMed ID: 30354297	2018
Potassium channel selectivity filter dynamics revealed by single-molecule FRET. Nature chemical biology\| PubMed ID: 30833778	2019
Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets. Physiological reports\| PubMed ID: 31161721	2019
ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle. The Journal of physiology\| PubMed ID: 34820842	2022