Gal Bitan

Brain Research Institute, University of California, Los Angeles

Affiliated withUniversity of California, Los Angeles David Geffen School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 89	2009
Publication title Cited by 27	2010

Other Publications

Article	Year
Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids. The Journal of organic chemistry\| PubMed ID: 11671417	1997
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. Journal of neuroscience research\| PubMed ID: 12210822	2002
Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiology of disease\| PubMed ID: 12460551	2002
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12506200	2003
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. The Journal of biological chemistry\| PubMed ID: 12840029	2003
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of clinical investigation\| PubMed ID: 12897209	2003
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society\| PubMed ID: 14664580	2003
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Accounts of chemical research\| PubMed ID: 15196045	2004
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. Journal of the American Chemical Society\| PubMed ID: 15713083	2005
Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15980591	2005
Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15980592	2005
Neurotoxic protein oligomers--what you see is not always what you get. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 16011984	2005
En route to early diagnosis of Alzheimer's disease--are we there yet? Trends in biotechnology\| PubMed ID: 16165236	2005
Amyloid beta-protein monomer structure: a computational and experimental study. Protein science : a publication of the Protein Society\| PubMed ID: 16501222	2006
Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiology of aging\| PubMed ID: 16725229	2007
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Accounts of chemical research\| PubMed ID: 16981680	2006
Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there? Expert review of neurotherapeutics\| PubMed ID: 17009917	2006
Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods in enzymology\| PubMed ID: 17046399	2006
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18779585	2008
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. Journal of molecular biology\| PubMed ID: 19356595	2009
Amino acid position-specific contributions to amyloid beta-protein oligomerization. The Journal of biological chemistry\| PubMed ID: 19567875	2009
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PloS one\| PubMed ID: 19901993	2009
Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry\| PubMed ID: 20050679	2010
Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. Journal of neurochemistry\| PubMed ID: 20345758	2010
Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry\| PubMed ID: 20568734	2010
Amyloid-Î² protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nature chemistry\| PubMed ID: 20703363	2009
Surprising toxicity and assembly behaviour of amyloid Î²-protein oxidized to sulfone. The Biochemical journal\| PubMed ID: 21044048	2011
Rational design of Î²-sheet ligands against AÎ²42-induced toxicity. Journal of the American Chemical Society\| PubMed ID: 21381732	2011
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society\| PubMed ID: 21916458	2011
Induction of methionine-sulfoxide reductases protects neurons from amyloid Î²-protein insults in vitro and in vivo. Biochemistry\| PubMed ID: 22059533	2011
C-terminal tetrapeptides inhibit AÎ²42-induced neurotoxicity primarily through specific interaction at the N-terminus of AÎ²42. Journal of medicinal chemistry\| PubMed ID: 22087474	2011
AÎ²(39-42) modulates aÎ² oligomerization but not fibril formation. Biochemistry\| PubMed ID: 22129303	2012
A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated AÎ²42 C-Terminal Fragments as AÎ²42 Toxicity Inhibitors. ChemMedChem\| PubMed ID: 22307963	2012
Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms. ChemMedChem\| PubMed ID: 22323134	2012