Tobias Madl

Gottfried Schatz Research Center for Cell Signaling, Medical University of Graz

Affiliated withMedical University of Graz

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2021

Other Publications

Article	Year
Enhanced inter-compartmental Ca flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox biology\| PubMed ID: 30458321	2019
Hop/Sti1 phosphorylation inhibits its co-chaperone function. EMBO reports\| PubMed ID: 25504578	2015
A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain. Biophysical journal\| PubMed ID: 25650934	2015
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control. Nature communications\| PubMed ID: 25695750	2015
Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM. Biochimica et biophysica acta\| PubMed ID: 25748881	2015
Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nature communications\| PubMed ID: 25851214	2015
Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction. Molecular microbiology\| PubMed ID: 26172206	2015
The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin. The Journal of biological chemistry\| PubMed ID: 26459561	2015
Optimization of lipid production with a genome-scale model of Yarrowia lipolytica. BMC systems biology\| PubMed ID: 26503450	2015
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90. Scientific reports\| PubMed ID: 26593036	2015
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. eLife\| PubMed ID: 26744780	2016
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta neuropathologica\| PubMed ID: 26895297	2016
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network. Nature structural & molecular biology\| PubMed ID: 26974125	2016
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia\| PubMed ID: 27153842	2016
Prediction of Protein Structure Using Surface Accessibility Data. Angewandte Chemie (International ed. in English)\| PubMed ID: 27560616	2016
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells. Nature communications\| PubMed ID: 27642082	2016
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 27710939	2016
Importance of cycle timing for the function of the molecular chaperone Hsp90. Nature structural & molecular biology\| PubMed ID: 27723736	2016
Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent. Angewandte Chemie (International ed. in English)\| PubMed ID: 27763708	2016
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). The FEBS journal\| PubMed ID: 28236663	2017
Long-range allosteric signaling in red light-regulated diguanylyl cyclases. Science advances\| PubMed ID: 28275738	2017
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19. Nature communications\| PubMed ID: 28281558	2017
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes. Scientific reports\| PubMed ID: 28287098	2017
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell\| PubMed ID: 28340339	2017
Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations. PloS one\| PubMed ID: 28355271	2017
Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity. The Journal of allergy and clinical immunology\| PubMed ID: 28532654	2017
RNA structure refinement using NMR solvent accessibility data. Scientific reports\| PubMed ID: 28710477	2017
Characterization of Protein-Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements. Journal of the American Chemical Society\| PubMed ID: 28780861	2017
Patchy proteins form a perfect lens. Science (New York, N.Y.)\| PubMed ID: 28798115	2017
Integrative metabolomics as emerging tool to study autophagy regulation. Microbial cell (Graz, Austria)\| PubMed ID: 28845422	2017
Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo. Nature communications\| PubMed ID: 29127288	2017
A switch point in the molecular chaperone Hsp90 responding to client interaction. Nature communications\| PubMed ID: 29662162	2018
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation. Cell\| PubMed ID: 29677514	2018
Regulation of cellular senescence via the FOXO4-p53 axis. FEBS letters\| PubMed ID: 29683489	2018
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis. Journal of hepatology\| PubMed ID: 29709678	2018
Acetate-free, citrate-acidified bicarbonate dialysis improves serum calcification propensity-a preliminary study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 29860419	2018
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation. Science advances\| PubMed ID: 29963623	2018
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting. Cell metabolism\| PubMed ID: 30122555	2018
Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae. Protein science : a publication of the Protein Society\| PubMed ID: 30267443	2019
NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability. Scientific reports\| PubMed ID: 30279548	2018
Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes. Frontiers in physiology\| PubMed ID: 30487758	2018
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 30595160	2019
A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers. PloS one\| PubMed ID: 30707717	2019
Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 30790505	2019
pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments. ACS sensors\| PubMed ID: 30864782	2019
The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Molecular cell\| PubMed ID: 30876805	2019
Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease. Circulation research\| PubMed ID: 30929571	2019
Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex. Journal of molecular biology\| PubMed ID: 31034892	2019
Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients. Scientific reports\| PubMed ID: 31043697	2019
Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovascular research\| PubMed ID: 31166588	2020
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK. The Journal of biological chemistry\| PubMed ID: 31209110	2019
Endothelial lipase increases antioxidative capacity of high-density lipoprotein. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 31220617	2019
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins. Journal of biomolecular NMR\| PubMed ID: 31297688	2019
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Cell metabolism\| PubMed ID: 31471173	2019
Presenilin-1 Established ER-Ca Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 31529929	2019
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16. Redox biology\| PubMed ID: 31539802	2020
A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro. FEBS letters\| PubMed ID: 31605637	2020
Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine. Nucleic acids research\| PubMed ID: 31754719	2020
Probing Surfaces in Dynamic Protein Interactions. Journal of molecular biology\| PubMed ID: 32135192	2020
Nonclassical nuclear localization signals mediate nuclear import of CIRBP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32234784	2020
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice. Scientific reports\| PubMed ID: 32286473	2020
Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner. mSystems\| PubMed ID: 32518196	2020
Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice. The Journal of biological chemistry\| PubMed ID: 32546481	2020
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Science translational medicine\| PubMed ID: 33115954	2020
β-catenin regulates FOXP2 transcriptional activity via multiple binding sites. The FEBS journal\| PubMed ID: 33284517	2021
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. Cell reports\| PubMed ID: 33357437	2020
Imbalances in the eye lens proteome are linked to cataract formation. Nature structural & molecular biology\| PubMed ID: 33432246	2021
Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL. International journal of molecular sciences\| PubMed ID: 33450841	2021
Tissue-Specific Landscape of Metabolic Dysregulation during Ageing. Biomolecules\| PubMed ID: 33562384	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy\| PubMed ID: 33634751	2021
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 33646155	2021
Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia. International journal of molecular sciences\| PubMed ID: 33671212	2021
Dietary spermidine improves cognitive function. Cell reports\| PubMed ID: 33852843	2021
NLRP3 as a sensor of metabolism gone awry. Current opinion in biotechnology\| PubMed ID: 33862489	2021
Potassium ions promote hexokinase-II dependent glycolysis. iScience\| PubMed ID: 33870140	2021
Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming. Cancers\| PubMed ID: 33924061	2021
ATP regulates RNA-driven cold inducible RNA binding protein phase separation. Protein science : a publication of the Protein Society\| PubMed ID: 33991007	2021
Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy. ACS sensors\| PubMed ID: 34282892	2021
Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function. Cell reports\| PubMed ID: 34320339	2021
Metabolic profiling links cardiovascular risk and vascular end organ damage. Atherosclerosis\| PubMed ID: 34344526	2021
Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR. The Journal of biological chemistry\| PubMed ID: 34487759	2021
Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans. Microbiome\| PubMed ID: 34560884	2021
Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients. Nutrients\| PubMed ID: 34578983	2021
Intracellular drug binding affinities by NMR. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34605425	2021
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation. Frontiers in molecular biosciences\| PubMed ID: 34738012	2021
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells. Science immunology\| PubMed ID: 34739338	2021
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR. International journal of molecular sciences\| PubMed ID: 34768862	2021